2017
Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules
Niu Y, Moghimyfiroozabad S, Safaie S, Yang Y, Jonas EA, Alavian KN. Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules. Journal Of Molecular Evolution 2017, 85: 219-233. PMID: 29177973, PMCID: PMC5709465, DOI: 10.1007/s00239-017-9819-3.Peer-Reviewed Original ResearchConceptsBacterial transcription unitsF1Fo-ATP synthaseHuman mitochondrial proteinsTranscription unitATP synthaseMitochondrial proteinsPhylogenetic profilesF-type ATP synthaseATP synthase genesSeparate transcription unitsKingdoms of lifeATP synthase complexPeripheral stalk subunitsC subunit ringComplex evolutionary processesAncestral modulesPhylogenetic profilingModular evolutionSynthase complexBacterial genomesUniversal enzymeSynthase geneBacterial classesIndependent assemblyΑ3β3 hexamer
2012
Multipolar functions of BCL-2 proteins link energetics to apoptosis
Hardwick JM, Chen YB, Jonas EA. Multipolar functions of BCL-2 proteins link energetics to apoptosis. Trends In Cell Biology 2012, 22: 318-328. PMID: 22560661, PMCID: PMC3499971, DOI: 10.1016/j.tcb.2012.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspasesEvolution, MolecularHumansMitochondrial MembranesProto-Oncogene Proteins c-bcl-2ConceptsBcl-2 proteinClassical apoptotic cell deathBcl-2 family proteinsSub-mitochondrial localizationApoptotic cell deathFamily proteinsClassical apoptosisBiochemical activityApoptosis regulatorCritical crosstalkCell survivalCell deathProteinApoptosisProfound effectCellsMultipolar functionsRegulatorCrosstalkLocalizationCurrent assumptionsDeath