2024
Polyvascular Disease: A Narrative Review of Risk Factors, Clinical Outcomes and Treatment
Tannu M, Hess C, Gutierrez J, Lopes R, Swaminathan R, Altin S, Rao S. Polyvascular Disease: A Narrative Review of Risk Factors, Clinical Outcomes and Treatment. Current Cardiology Reports 2024, 26: 505-520. PMID: 38743352, DOI: 10.1007/s11886-024-02063-0.Peer-Reviewed Original ResearchGlobal burdenIncreased riskPolyvascular diseaseIncreased risk of bleedingIncreased risk of adverse outcomesRisk factorsVascular territoriesLow-dose anticoagulationLevels of atherogenic lipoproteinsRisk of adverse outcomesAssociated with increased riskLipid-lowering therapyRisk of bleedingAdverse cardiac eventsType 2 diabetes mellitusHigh-risk subgroupsDose of therapyReview of risk factorsReduce disease progressionPresence of atherosclerosisOptimal timingP2Y12 inhibitorsTreatment intensificationEscalating treatmentIschemic benefit
2023
Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication
Altin S, Parise H, Hess C, Rosenthal N, Creager M, Aronow H, Curtis J. Long-Term Patient Outcomes After Femoropopliteal Peripheral Vascular Intervention in Patients With Intermittent Claudication. JACC Cardiovascular Interventions 2023, 16: 1668-1678. PMID: 37438035, DOI: 10.1016/j.jcin.2023.05.001.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsIndex limb amputationAmputation rateIntermittent claudicationMajor amputationRevascularization ratesVascular interventionsCox proportional hazards regressionLong-term patient outcomesMajor amputation rateProportional hazards regressionKaplan-Meier estimatesFurther risk factorsLimb amputation rateClinical trial dataIndex limbIC patientsSecondary outcomesPrimary outcomeHazards regressionRisk factorsPatient outcomesLimb amputationHealthcare databasesPatients
2022
Sex Differences in Peripheral Artery Disease
Pabon M, Cheng S, Altin S, Sethi S, Nelson M, Moreau K, Hamburg N, Hess C. Sex Differences in Peripheral Artery Disease. Circulation Research 2022, 130: 496-511. PMID: 35175843, PMCID: PMC8919803, DOI: 10.1161/circresaha.121.320702.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseManagement of PADSuch sex-based differencesNontraditional risk factorsSex differencesLack of diagnosisSex-based differencesImportant sex differencesIschemic cardiovascularPAD prevalenceVascular stressorSubstantial morbidityClinical presentationClinical manifestationsRisk factorsPrevalent conditionLimb eventsOverall populationVascular substratesDiseaseSex variationWomenCurrent knowledgeManifestations
2021
Outcomes of mechanical circulatory support for acute myocardial infarction complicated by cardiogenic shock
Kim Y, Shapero K, Ahn SS, Goldsweig AM, Desai N, Altin SE. Outcomes of mechanical circulatory support for acute myocardial infarction complicated by cardiogenic shock. Catheterization And Cardiovascular Interventions 2021, 99: 658-663. PMID: 34156755, PMCID: PMC10877703, DOI: 10.1002/ccd.29834.Peer-Reviewed Original ResearchConceptsIntra-aortic balloon pumpMechanical circulatory supportAcute kidney injuryNational Inpatient SampleHospital mortalityAcute myocardial infarctionCardiogenic shockKidney injuryCirculatory supportMyocardial infarctionNational Cardiovascular Data RegistryPropensity scoreEfficacy of ImpellaPremier Healthcare DatabaseRetrospective cohort studyHigher hospital costsLength of stayReal-world observational dataImpella useCohort studyImpella deviceBalloon pumpPrimary outcomeInpatient SampleRisk factors