2012
Inhibition of Bacterial Virulence: Drug‐Like Molecules Targeting the Salmonella enterica PhoP Response Regulator
Tang YT, Gao R, Havranek JJ, Groisman EA, Stock AM, Marshall GR. Inhibition of Bacterial Virulence: Drug‐Like Molecules Targeting the Salmonella enterica PhoP Response Regulator. Chemical Biology & Drug Design 2012, 79: 1007-1017. PMID: 22339993, PMCID: PMC3445336, DOI: 10.1111/j.1747-0285.2012.01362.x.Peer-Reviewed Original ResearchConceptsTwo-component signal transductionResponse regulatorPhoP response regulatorHistidine kinaseBacterial virulenceGene expressionSensor histidine kinaseVirulence gene regulationSignal transduction systemSignal transduction pathwaysExpression of genesTCST systemsStructure-based virtual screeningGene regulationSignal transductionTranscription factorsTransduction pathwaysTransduction systemVirtual screeningBiophysical assaysAntibacterial developmentMode of actionExternal signalsRegulatorRegulatory system
1993
Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.
Groisman EA, Ochman H. Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. The EMBO Journal 1993, 12: 3779-87. PMID: 8404849, PMCID: PMC413660, DOI: 10.1002/j.1460-2075.1993.tb06056.x.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigens, BacterialAntigens, SurfaceBase SequenceBlotting, SouthernChromosomes, BacterialDNAEpithelial CellsEpitheliumGenes, BacterialGenetic Complementation TestHumansMiceMolecular Sequence DataMultigene FamilyMutationRestriction MappingSalmonella typhimuriumSequence Homology, Amino AcidShigella flexneriTumor Cells, CulturedConceptsEpithelial cellsEnteric pathogen Salmonella typhimuriumHost epithelial cellsSurface antigenSalmonella typhimuriumPathogen Salmonella typhimuriumConstellation of genesInvasion propertiesShigella flexneriVirulence plasmidShigellaVirulence attributesAntigenSalmonellaBacterial entryProtein secretion
1992
Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome.
Groisman EA, Saier MH, Ochman H. Horizontal transfer of a phosphatase gene as evidence for mosaic structure of the Salmonella genome. The EMBO Journal 1992, 11: 1309-1316. PMID: 1339343, PMCID: PMC556579, DOI: 10.1002/j.1460-2075.1992.tb05175.x.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAmino Acid SequenceBase CompositionBase SequenceChromosomes, BacterialCloning, MolecularCodonDNAEscherichia coliGenes, BacterialGenome, BacterialMolecular Sequence DataMosaicismPhylogenyPlasmidsRestriction MappingSalmonella typhimuriumSequence Homology, Nucleic AcidTransfectionConceptsBase compositionPhoN geneNon-specific acid phosphatase activityAtypical base compositionSpacing of genesOverall base compositionNon-specific acid phosphataseCodon usage patternsGram-negative speciesChromosome sizeBacterial genomesPhosphatase geneKb regionSalmonella chromosomeSalmonella genomeGenetic basisHorizontal transferAcid phosphatase activityTrinucleotide frequenciesHigh similarityGenomeGenesEscherichia coliPhosphatase activityOriT region
1988
Isolation, characterization, and cloning of a plasmid-borne gene encoding a phosphotransferase that confers high-level amikacin resistance in enteric bacilli
Gaynes R, Groisman E, Nelson E, Casadaban M, Lerner S. Isolation, characterization, and cloning of a plasmid-borne gene encoding a phosphotransferase that confers high-level amikacin resistance in enteric bacilli. Antimicrobial Agents And Chemotherapy 1988, 32: 1379-1384. PMID: 2848443, PMCID: PMC175872, DOI: 10.1128/aac.32.9.1379.Peer-Reviewed Original Research