2017
Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation
May J, Rasmussen D, Davie T, Vaneerd C, Groisman E, Bhattacharyya B. Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.761.11.Peer-Reviewed Original ResearchPeriplasmic lipoproteinMagnesium limitationAtomic-resolution structural dataFamily of proteinsFundamental biochemical processesBeta-sheet secondary structureAdaptation of SalmonellaGenetic screenCircular dichroism spectroscopyBacterial adaptationLocalization sequenceSalmonella proteinsBiochemical approachesIon homeostasisBacterial virulenceProtein monomersBiochemical characterizationCertain pathogenic bacteriaMolecular mechanismsMonomeric molecular weightUnknown functionPhysiological functionsLiving cellsSecondary structureDichroism spectroscopy
2016
Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho
Kriner MA, Sevostyanova A, Groisman EA. Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho. Trends In Biochemical Sciences 2016, 41: 690-699. PMID: 27325240, PMCID: PMC4967001, DOI: 10.1016/j.tibs.2016.05.012.Peer-Reviewed Original ResearchConceptsRho-dependent terminatorsLeader regionTranscription termination factor RhoTranscription elongation complexTermination factor RhoTranscription termination eventsTranscription of genesRho-dependent terminationRho loading siteElongation complexGene regulationCellular translationBacterial mRNAsRegulatory inputsPhysiological functionsProtein synthesisTermination eventsNovel mechanismTarget specificityMultistep natureRhoLoading siteMultiple signalsTerminatorRecent studies
2008
Signal integration in bacterial two-component regulatory systems
Mitrophanov AY, Groisman EA. Signal integration in bacterial two-component regulatory systems. Genes & Development 2008, 22: 2601-2611. PMID: 18832064, PMCID: PMC2751022, DOI: 10.1101/gad.1700308.Peer-Reviewed Original ResearchConceptsTwo-component systemResponse regulatorTwo-component regulatory systemSignal integrationBacterial signal transductionGram-negative bacteriaCellular processesSignal transductionPhosphorylated statePhosphorylation statePhysiological functionsSpecific functionsRegulatory systemBiochemical reactionsKey mediatorRegulatorPhosphorelayAntibiotic resistanceDifferent mechanismsSporulationTransductionStationary phaseDNABacteriaGram