2025
Infection-relevant conditions dictate differential versus coordinate expression of Salmonella chaperones and cochaperones
Chan C, Mukai K, Groisman E. Infection-relevant conditions dictate differential versus coordinate expression of Salmonella chaperones and cochaperones. MBio 2025, 16: e00227-25. PMID: 40162747, PMCID: PMC12077118, DOI: 10.1128/mbio.00227-25.Peer-Reviewed Original ResearchConceptsInfection-relevant conditionsJ-domainProtein homeostasisChaperone DnaKCytoplasmic MgMolecular chaperonesNucleotide exchange factor GrpEChaperone trigger factorSigma factor RpoHProteins co-translationallyExpression of molecular chaperonesPreventing protein aggregationIncreased mRNA amountsPerturb protein homeostasisMRNA amountsCochaperone DnaJRpoH proteinCo-translationallyPost-translationallyCochaperoneExpressed genesFolded proteinsDnaKCoordinated expressionChaperone
2024
Chaperone Hsp70 helps Salmonella survive infection-relevant stress by reducing protein synthesis
Chan C, Groisman E. Chaperone Hsp70 helps Salmonella survive infection-relevant stress by reducing protein synthesis. PLOS Biology 2024, 22: e3002560. PMID: 38574172, PMCID: PMC10994381, DOI: 10.1371/journal.pbio.3002560.Peer-Reviewed Original ResearchConceptsRibosome associationProtein synthesisProtein homeostasisS. typhimuriumProtein folding capacityPreventing protein aggregationC-terminal amino acidsDomains of lifeProtein synthesis in vitroInhibit protein synthesisFolding capacityHsp70 chaperonesJ-domainSynthesis in vitroProtein foldingReduction of protein synthesisChaperone Hsp70DnaKRibosomeProtein aggregationChaperoneAmino acidsProteinStarvationHSP70
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