2025
Atypical presentation of occult congenital diaphragmatic hernia as intermittent obstructive symptoms: A case report
Haynes C, Thaxton C, Shaughnessy M, Stitelman D. Atypical presentation of occult congenital diaphragmatic hernia as intermittent obstructive symptoms: A case report. Journal Of Pediatric Surgery Case Reports 2025, 117: 103018. DOI: 10.1016/j.epsc.2025.103018.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaLate-onset congenital diaphragmatic herniaDiaphragmatic herniaObstructive symptomsAbdominal painDifferential diagnosis of childrenIntermittent obstructive symptomsNormal stooling patternObstructive bowel symptomsRightward mediastinal shiftPost-operative courseFive-month historyNormal bowel movementsAcute respiratory distressMonths of lifeAcute intestinal obstructionDiagnosis of childrenPrenatal suspicionBands of scar tissueAtypical presentationCongenital anomaliesStool patternMediastinal shiftBowel obstructionFibrotic bands
2024
Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Rivero R, Stitelman D. Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery. Current Stem Cell Reports 2024, 10: 51-57. DOI: 10.1007/s40778-024-00237-8.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaDiaphragmatic herniaAnimal modelsIntra-amniotic injectionLong-term functional outcomeParticle-based deliveryFetal therapyPrenatal therapySpinal defectsTarget specific tissuesCo-morbiditiesCongenital diseaseFunctional outcomesTreatment deliveryStructural diseaseClinical translationMyelomeningoceleTherapyHerniaSpecific tissuesTissueDiseaseDeliveryPrenatallyParticle delivery
2023
In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia
Ullrich S, Yung N, Bauer-Pisani T, Maassel N, Guerra M, Freedman-Weiss M, Ahle S, Ricciardi A, Sauler M, Saltzman W, Piotrowski-Daspit A, Stitelman D. In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia. Molecular Therapy - Nucleic Acids 2023, 32: 594-602. PMID: 37200861, PMCID: PMC10185702, DOI: 10.1016/j.omtn.2023.04.018.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaTGF-β pathwayDiaphragmatic herniaFetal ratsPulmonary vascular remodelingLung function resultsGestational day 18Pre-clinical modelsDifferent gestational timesCritical illnessPulmonary pathologyLung growthLung sizeRat modelFetal casesLung morphologyVascular remodelingMicroRNA-200bVein injectionFetal diseaseFirst breathDay 18Lung developmentGestational timeInvasive fashion
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