2016
β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey-Smith S, Martins RN, Salvado O, Dore V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Maruff P, Pietrzak RH, Australian Imaging B. β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal Of Geriatric Psychiatry 2016, 24: 1191-1195. PMID: 27742526, DOI: 10.1016/j.jagp.2016.08.007.Peer-Reviewed Original ResearchConceptsBDNF genotypeNormal older womenAnxiety symptomsOlder adultsΕ4 carriageOlder womenDepressive symptomsΒ-amyloidGreater severityAustralian Imaging BiomarkersNon-ε4 carriersSeverity of depressiveMet allele carriersSeverity of anxietyGreater depressive symptomsNormal older adultsGreater anxiety symptomsLifestyle StudyΕ4 carriersAPOE genotypeAllele carriersAnalysis of covarianceImaging biomarkersSymptomsDepressive
2010
Computerized ambulatory monitoring in mood disorders: Feasibility, compliance, and reactivity
Husky MM, Gindre C, Mazure CM, Brebant C, Nolen-Hoeksema S, Sanacora G, Swendsen J. Computerized ambulatory monitoring in mood disorders: Feasibility, compliance, and reactivity. Psychiatry Research 2010, 178: 440-442. PMID: 20488558, DOI: 10.1016/j.psychres.2010.04.045.Peer-Reviewed Original Research
2007
Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men
Hyman SM, Paliwal P, Chaplin TM, Mazure CM, Rounsaville BJ, Sinha R. Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men. Drug And Alcohol Dependence 2007, 92: 208-216. PMID: 17900822, PMCID: PMC2233653, DOI: 10.1016/j.drugalcdep.2007.08.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAdult Survivors of Child AbuseChildChild Abuse, SexualCocaine-Related DisordersData Interpretation, StatisticalFemaleFollow-Up StudiesHumansInpatientsMaleMiddle AgedPredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesRecurrenceSex CharacteristicsSocioeconomic FactorsSubstance Abuse Treatment CentersSurveys and QuestionnairesConceptsOverall childhood traumaCocaine relapse outcomesChildhood traumaEmotional abuseRelapse outcomesChildhood emotional abuseCocaine treatment outcomesCocaine-dependent menCocaine-dependent adultsCocaine relapseAssociation of severityRisk of relapseSexual abusePhysical abuseGender-specific effectsInitial relapseDay cocaineCocaine dependenceDependent adultsInpatient SampleInpatient treatmentTreatment outcomesGreater severityAbuseDependent men
2004
Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study
Nelson JC, Mazure CM, Jatlow PI, Bowers MB, Price LH. Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biological Psychiatry 2004, 55: 296-300. PMID: 14744472, DOI: 10.1016/j.biopsych.2003.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAntidepressive Agents, Second-GenerationAntidepressive Agents, TricyclicChromatography, High Pressure LiquidDepressive DisorderDesipramineDouble-Blind MethodDrug Therapy, CombinationFemaleFluoxetineHumansMaleMiddle AgedNorepinephrinePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSerotoninTreatment OutcomeConceptsMontgomery-Asberg Depression Rating ScaleHamilton Depression Rating Scale scoresDepression Rating Scale scoresNonpsychotic unipolar major depressionPatient withdrew consentTreatment-resistant patientsWeeks of hospitalizationWeeks of treatmentCombination of fluoxetineOnset of actionAdequate plasma levelsDouble-blind conditionsDepression Rating ScaleTreatment of depressionRating Scale scoresUnipolar major depressionDrug plasma concentrationsDMI doseWithdrew consentAntidepressant medicationRandomized studyReuptake inhibitionSerotonergic agentsPlasma levelsMajor depression
2003
Psychotic Depression and Mortality
Vythilingam M, Chen J, Bremner JD, Mazure CM, Maciejewski PK, Nelson JC. Psychotic Depression and Mortality. American Journal Of Psychiatry 2003, 160: 574-576. PMID: 12611843, DOI: 10.1176/appi.ajp.160.3.574.Peer-Reviewed Original ResearchConceptsPsychotic depressionNonpsychotic major depressionHigh mortality rateMortality rateMajor depressionHospital admissionNonpsychotic depressionVital statusMedical statusCumulative Illness Rating ScaleIllness Rating ScaleMajor depressive disorderProportional hazards modelSeverity of depressionPsychotic major depressionPositive DST resultsSurvival analytic techniquesElevated mortality ratesDepressive disorderDST resultsHazards modelPatientsGreater riskRating ScaleDepression
2002
Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression
Mazure CM, Maciejewski PK, Jacobs SC, Bruce ML. Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression. American Journal Of Geriatric Psychiatry 2002, 10: 297-304. PMID: 11994217, DOI: 10.1097/00019442-200205000-00009.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetAgedAged, 80 and overCognitionConnecticutDepressive DisorderFemaleHumansLife Change EventsMalePersonalityPredictive Value of TestsPsychiatric Status Rating ScalesConceptsPersonality stylesCognitive theoryBeck's cognitive theoryStressful life eventsLife eventsLife stressorsYears of educationMajor depressionDepression onsetUnipolar major depressionOnset major depressionDepressionStyleLate-onset depressionPositive associationPhysical functioningFunctioningStressorsMedical illnessControl subjectsCurrent workMultivariate modelElderly outpatientsTheory
2001
Clozapine in the treatment of aggression in an adolescent with autistic disorder.
Chen N, Bedair H, McKay B, Bowers M, Mazure C. Clozapine in the treatment of aggression in an adolescent with autistic disorder. The Journal Of Clinical Psychiatry 2001, 62: 479-80. PMID: 11465533, DOI: 10.4088/jcp.v62n0612h.Peer-Reviewed Original ResearchAdolescentAggressionAntipsychotic AgentsAutistic DisorderClozapineDrug Administration ScheduleHumansMalePsychiatric Status Rating ScalesTreatment Outcome
2000
Adverse Life Events and Cognitive-Personality Characteristics in the Prediction of Major Depression and Antidepressant Response
Mazure CM, Bruce ML, Maciejewski PK, Jacobs SC. Adverse Life Events and Cognitive-Personality Characteristics in the Prediction of Major Depression and Antidepressant Response. American Journal Of Psychiatry 2000, 157: 896-903. PMID: 10831468, DOI: 10.1176/appi.ajp.157.6.896.Peer-Reviewed Original ResearchConceptsCognitive-personality stylesCognitive–personality characteristicsAdverse life eventsStressful life eventsMajor depressionLife eventsTreatment outcomesComparison subjectsDepressive onsetMultivariate modelCommunity comparison subjectsDSM-IV unipolar depressionDepressive symptom severityHealthy comparison subjectsEvent typesAntidepressant regimenAdverse eventsAntidepressant responseInterpersonal eventsAchievement eventsUnipolar depressionBetter outcomesEpisode onsetSymptom severityGroup statusDevelopment and preliminary psychometric properties of an instrument for the measurement of childhood trauma: The early trauma inventory
Bremner J, Vermetten E, Mazure C. Development and preliminary psychometric properties of an instrument for the measurement of childhood trauma: The early trauma inventory. Depression And Anxiety 2000, 12: 1-12. PMID: 10999240, DOI: 10.1002/1520-6394(2000)12:1<1::aid-da1>3.0.co;2-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesChildChild AbuseDepressionFemaleHumansMaleMental DisordersMiddle AgedObserver VariationOdds RatioPanic DisorderPredictive Value of TestsPsychiatric Status Rating ScalesPsychometricsReproducibility of ResultsSchizophreniaStress Disorders, Post-TraumaticTrauma Severity IndicesConceptsEarly Trauma InventoryAbuse/traumaPreliminary psychometric propertiesChildhood traumaTrauma InventoryTraumatic experiencesPsychometric propertiesEarly traumatic experiencesAssessment of traumaGood convergent validityValid instrumentAcceptable inter-rater reliabilityTest-retest reliabilityMeasurement of symptomsSexual abuseConvergent validityComparison subjectsInternal consistencyPTSDInter-rater reliabilityAbuseInventoryTraumaValidityExperience
1997
Recent life stressors and biological markers in newly admitted psychotic patients
Mazure C, Quinlan D, Bowers M. Recent life stressors and biological markers in newly admitted psychotic patients. Biological Psychiatry 1997, 41: 865-870. PMID: 9099413, DOI: 10.1016/s0006-3223(96)00222-3.Peer-Reviewed Original Research
1995
Assessment of extrapyramidal symptoms during acute neuroleptic treatment.
Mazure CM, Cellar JS, Bowers MB, Nelson JC, Takeshita J, Zigun B. Assessment of extrapyramidal symptoms during acute neuroleptic treatment. The Journal Of Clinical Psychiatry 1995, 56: 94-100. PMID: 7883736.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAkathisia, Drug-InducedAntipsychotic AgentsBasal Ganglia DiseasesDystoniaFemaleHumansMaleMiddle AgedParkinson Disease, SecondaryPhysical ExaminationPsychiatric Status Rating ScalesPsychotic DisordersReproducibility of ResultsSeverity of Illness IndexStatistics, NonparametricConceptsExtrapyramidal symptomsDrug regimenAcute treatmentNeuroleptic drugsSide effectsInterrater reliabilityAcute neuroleptic treatmentPatient's drug regimenExtrapyramidal Symptoms ScaleExtrapyramidal side effectsTraditional neuroleptic drugsLow nonsignificant correlationsRatings of symptomsAcute administrationNeuroleptic treatmentAdverse reactionsParkinson's diseasePsychotic symptomsSymptom ScalePsychotic patientsEPS scaleSymptomsClinician ratersCliniciansInterrater agreementDSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity
Mazure CM, Kincare P, Schaffer CE. DSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity. Psychiatry 1995, 58: 56-64. PMID: 7792323, DOI: 10.1080/00332747.1995.11024711.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAgedBipolar DisorderDementiaDepressive DisorderFemaleHumansMaleMiddle AgedPatient AdmissionPersonality AssessmentPsychiatric Status Rating ScalesPsychometricsPsychotic DisordersReproducibility of ResultsRisk FactorsSchizophreniaSchizophrenic PsychologySomatoform DisordersStress, PsychologicalConceptsPsychosocial stressorsAxis IVClinical setting todayMultiaxial diagnostic systemImportant precipitantsExacerbation of psychopathologyPatient reportsPatients' appraisalPsychiatric disordersClinical ratingsClinician reliabilityObjective ratingsSeverityExacerbationStressor severityNosological systemsReportStressorsSubjective appraisalClinicians
1994
The Yale-Brown-Cornell eating disorder scale: Development, use, reliability and validity
Mazure C, Halmi K, Sunday S, Romano S, Einhorn A. The Yale-Brown-Cornell eating disorder scale: Development, use, reliability and validity. Journal Of Psychiatric Research 1994, 28: 425-445. PMID: 7897615, DOI: 10.1016/0022-3956(94)90002-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAnorexia NervosaBulimiaFemaleHumansMiddle AgedPersonalityPsychiatric Status Rating ScalesReproducibility of ResultsSeverity of Illness IndexConceptsProvisional itemsEating Disorder ScaleEight-item scaleDisorder ScaleYale-BrownUnique symptomatologyEating-related concernsEating-disordered patientsCornell Eating Disorder ScaleBody dissatisfactionDisorder symptomatologyYBC-EDSConvergent validityIndications of validityClinician-rated instrumentsInternal consistencyDisorder assessmentMotivationExcellent interrater reliabilityIndependent samplesDisorder patientsSymptomatologyItemsDSM-IIIInitial findingsCharacteristics of desipramine-refractory depression.
Nelson JC, Mazure CM, Jatlow PI. Characteristics of desipramine-refractory depression. The Journal Of Clinical Psychiatry 1994, 55: 12-9. PMID: 8294386.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive DisorderDesipramineDrug Administration ScheduleFemaleHospitalizationHumansMaleMiddle AgedProbabilityPsychiatric Status Rating ScalesRegression AnalysisSeverity of Illness IndexTreatment OutcomeConceptsDepressive episodePoor responseMajor depressionNonpsychotic unipolar major depressionPrior treatment failureAdequate blood levelsWeeks of hospitalizationDrug responseUnipolar major depressionRecurrence of depressionDefinite personality disorderDiagnosis of melancholiaConsecutive inpatientsDesipramine levelsTreatment failureBlood levelsGeneral HospitalInitial severityPlasma concentrationsDrug treatmentSecondary depressionDepression InventoryPatientsPersonality disorderDepression
1992
Lithium in combination with perphenazine: effect on plasma monoamine metabolites
Bowers M, Mazure C, Nelson J, Jatlow P. Lithium in combination with perphenazine: effect on plasma monoamine metabolites. Biological Psychiatry 1992, 32: 1102-1107. PMID: 1477190, DOI: 10.1016/0006-3223(92)90190-b.Peer-Reviewed Original ResearchDrug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1991
Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis
Mazure C, Nelson J, Jatlow P, Bowers M. Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Biological Psychiatry 1991, 30: 475-482. PMID: 1932395, DOI: 10.1016/0006-3223(91)90309-a.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultBipolar DisorderChromatography, High Pressure LiquidDepressive DisorderDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMiddle AgedPerphenazinePrognosisProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsPlasma homovanillic acidHomovanillic acidFree homovanillic acidClinical responseEarly clinical responsePlasma-free homovanillic acidUseful clinical predictorClinical predictorsNeuroleptic treatmentAcute psychosisDopamine metabolismNoradrenergic functioningMethoxyhydroxyphenylglycolFavorable responsePsychotic inpatientsGood responseSignificant declineA Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression. JAMA Psychiatry 1991, 48: 303-307. PMID: 2009031, DOI: 10.1001/archpsyc.1991.01810280019002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDepressive DisorderDesipramineDrug Administration ScheduleDrug Therapy, CombinationFemaleFluoxetineHospitalizationHumansMaleMiddle AgedPsychiatric Status Rating ScalesConceptsMajor depressionMean changeHamilton Depression Rating Scale scoresDepression Rating Scale scoresCombination of fluoxetineDesipramine plasma levelsRating Scale scoresBeta-adrenergic receptorsOpen studyDesipramine levelsPlasma levelsStandardized doseScale scoreDesipramineDesipramine hydrochlorideRapid treatmentPatientsFluoxetineDrugsWeeksDepressionInpatientsTreatmentRecent studiesSame setting
1990
Valproate in the treatment of temper outbursts.
Giakas WJ, Seibyl JP, Mazure CM. Valproate in the treatment of temper outbursts. The Journal Of Clinical Psychiatry 1990, 51: 525. PMID: 2258370.Peer-Reviewed Original ResearchEpilepsy, Temporal LobeHumansMaleMiddle AgedNeurocognitive DisordersPsychiatric Status Rating ScalesRageValproic AcidValue of the DST for predicting response of patients with major depression to hospitalization and desipramine
Nelson JC, Mazure CM, Jatlow PI. Value of the DST for predicting response of patients with major depression to hospitalization and desipramine. American Journal Of Psychiatry 1990, 147: 1488-1492. PMID: 2221161, DOI: 10.1176/ajp.147.11.1488.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive DisorderDesipramineDexamethasoneFemaleHospitalizationHumansHydrocortisoneMaleProbabilityPsychiatric Status Rating ScalesConceptsDexamethasone suppression testResponse of patientsMajor depressionNegative dexamethasone suppression testPositive dexamethasone suppression testWeeks of hospitalizationNonpsychotic major depressionPlasma levelsSuppression testRate of responseAntidepressant drugsDrug treatmentPatientsHospitalizationDesipraminePrior reportsDepressionResponsePrior studiesPlaceboFindingsTrialsWeeks