2004
Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study
Nelson JC, Mazure CM, Jatlow PI, Bowers MB, Price LH. Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biological Psychiatry 2004, 55: 296-300. PMID: 14744472, DOI: 10.1016/j.biopsych.2003.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAntidepressive Agents, Second-GenerationAntidepressive Agents, TricyclicChromatography, High Pressure LiquidDepressive DisorderDesipramineDouble-Blind MethodDrug Therapy, CombinationFemaleFluoxetineHumansMaleMiddle AgedNorepinephrinePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSerotoninTreatment OutcomeConceptsMontgomery-Asberg Depression Rating ScaleHamilton Depression Rating Scale scoresDepression Rating Scale scoresNonpsychotic unipolar major depressionPatient withdrew consentTreatment-resistant patientsWeeks of hospitalizationWeeks of treatmentCombination of fluoxetineOnset of actionAdequate plasma levelsDouble-blind conditionsDepression Rating ScaleTreatment of depressionRating Scale scoresUnipolar major depressionDrug plasma concentrationsDMI doseWithdrew consentAntidepressant medicationRandomized studyReuptake inhibitionSerotonergic agentsPlasma levelsMajor depression
2002
Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression
Mazure CM, Maciejewski PK, Jacobs SC, Bruce ML. Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression. American Journal Of Geriatric Psychiatry 2002, 10: 297-304. PMID: 11994217, DOI: 10.1097/00019442-200205000-00009.Peer-Reviewed Original ResearchConceptsPersonality stylesCognitive theoryBeck's cognitive theoryStressful life eventsLife eventsLife stressorsYears of educationMajor depressionDepression onsetUnipolar major depressionOnset major depressionDepressionStyleLate-onset depressionPositive associationPhysical functioningFunctioningStressorsMedical illnessControl subjectsCurrent workMultivariate modelElderly outpatientsTheory
2001
Cognitive–Personality Characteristics as Direct Predictors of Unipolar Major Depression
Mazure C, Raghavan C, Maciejewski P, Jacobs S, Bruce M. Cognitive–Personality Characteristics as Direct Predictors of Unipolar Major Depression. Cognitive Therapy And Research 2001, 25: 215-225. DOI: 10.1023/a:1026424126287.Peer-Reviewed Original ResearchCognitive–personality characteristicsDirect predictorLife eventsCognitive-personality stylesStressful life eventsUnipolar major depressionAdverse life eventsDepressive vulnerabilityPersonality characteristicsCore featuresMajor depressionStrongest predictorCommunity controlsSpecific SubscaleDepressionMultiple risk factorsSocioeconomic statusPredictorsSociotropyDirect relationshipGlobal indexDepressive statusRisk factorsSubscalesStyle
1995
Desipramine Treatment of Major Depression in Patients Over 75 Years of Age
Nelson J, Mazure C, Jatlow P. Desipramine Treatment of Major Depression in Patients Over 75 Years of Age. Journal Of Clinical Psychopharmacology 1995, 15: 99-105.. PMID: 7782495, DOI: 10.1097/00004714-199504000-00004.Peer-Reviewed Original ResearchConceptsYounger patientsYears of ageElderly patientsMajor depressionDesipramine concentrationsDrug treatmentPatient trialsAdverse reaction rateMore effective drug treatmentsEffective drug treatmentUnipolar major depressionDesipramine treatmentDepressed patientsComparable dosesPatientsSide effectsResponse rateSimilar durationTrialsSecond trialTreatmentLower ratesBloodDepressionAge
1994
Characteristics of desipramine-refractory depression.
Nelson JC, Mazure CM, Jatlow PI. Characteristics of desipramine-refractory depression. The Journal Of Clinical Psychiatry 1994, 55: 12-9. PMID: 8294386.Peer-Reviewed Original ResearchConceptsDepressive episodePoor responseMajor depressionNonpsychotic unipolar major depressionPrior treatment failureAdequate blood levelsWeeks of hospitalizationDrug responseUnipolar major depressionRecurrence of depressionDefinite personality disorderDiagnosis of melancholiaConsecutive inpatientsDesipramine levelsTreatment failureBlood levelsGeneral HospitalInitial severityPlasma concentrationsDrug treatmentSecondary depressionDepression InventoryPatientsPersonality disorderDepression
1990
Predictors of hospital outcome without antidepressants in major depression
Mazure C, Nelson J, Jatlow P. Predictors of hospital outcome without antidepressants in major depression. Psychiatry Research 1990, 33: 51-58. PMID: 2217658, DOI: 10.1016/0165-1781(90)90148-x.Peer-Reviewed Original ResearchConceptsWeeks of hospitalizationHospital outcomesMajor depressionNonpsychotic unipolar major depressionPersonality disorderHamilton Rating ScaleDSM-III melancholiaUnipolar major depressionConsecutive inpatientsAdmission severityHRSD scoresIndependent associationPanic disorderRating ScaleHospital response
1985
Ruminative thinking A distinctive sign of melancholia
Nelson J, Mazure C. Ruminative thinking A distinctive sign of melancholia. Journal Of Affective Disorders 1985, 9: 41-46. PMID: 3160746, DOI: 10.1016/0165-0327(85)90008-4.Peer-Reviewed Original Research