Arie Kaffman, MD, PhD

Dr. Kaffman is a physician-scientist who works as a psychiatrist at the Newington VA, where he treats a large number of veterans with PTSD. He also has a basic neuroscience lab at Yale, where he studies the impact of early life adversity (ELA) on neurodevelopment and complex behavior in mice. Dr. Kaffman is a Principal Investigator on several NIH-funded grants that integrate molecular/cellular, genomic, pharmacological, and behavioral approaches with imaging techniques such as resting state fMRI and high-resolution dMRI conducted in rodents. This translational approach allows for a direct comparison between findings in rodents and human studies. The objective of this translational research is to elucidate the impact of early adversity on the neurodevelopment of circuits that regulate psychiatrically relevant behaviors, and to utilize this knowledge in the development of novel diagnostic and treatment modalities.