2013
Acute Kidney Injury and Bisphosphonate Use in Cancer: A Report From the Research on Adverse Drug Events and Reports (RADAR) Project
Edwards BJ, Usmani S, Raisch DW, McKoy JM, Samaras AT, Belknap SM, Trifilio SM, Hahr A, Bunta AD, Abu-Alfa A, Langman CB, Rosen ST, West DP. Acute Kidney Injury and Bisphosphonate Use in Cancer: A Report From the Research on Adverse Drug Events and Reports (RADAR) Project. JCO Oncology Practice 2013, 9: 101-106. PMID: 23814519, PMCID: PMC3595436, DOI: 10.1200/jop.2011.000486.Peer-Reviewed Original ResearchConceptsAcute kidney injuryZoledronic acidKidney injuryAdverse eventsProportional reporting ratioFDA AERSBisphosphonate useSafety signalsReporting ratioAdverse drug eventsDrug Administration adverse eventsAdverse drug reactionsCancer clinical trialsPremorbid diseaseRenal injuryRenal problemsMean ageMultiple myelomaDrug eventsDrug reactionsClinical trialsProstate cancerBreast cancerCancer settingUS Food
2008
The association of darbepoetin alfa with hemoglobin and health-related quality of life in patients with chronic kidney disease not receiving dialysis*
Abu-Alfa AK, Sloan L, Charytan C, Sekkarie M, Scarlata D, Globe D, Audhya P. The association of darbepoetin alfa with hemoglobin and health-related quality of life in patients with chronic kidney disease not receiving dialysis*. Current Medical Research And Opinion 2008, 24: 1091-1100. PMID: 18328118, DOI: 10.1185/030079908x280653.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseErythropoiesis-stimulating agentsHealth-related qualityDarbepoetin alfaWeek 52Week 12Kidney diseasePatients' health-related qualityGeneral CKD populationQ2W darbepoetin alfaWeek darbepoetin alfaGlomerular filtration rateSingle-arm studyBenefits of treatmentMean Hb concentrationYears of ageSubject inclusion criteriaCKD populationCreatinine clearanceHemoglobin levelsHb targetHb levelsHRQOL measuresFiltration rateInclusion criteria
2007
Are Patients with Moderate Renal Failure at Risk for Developing Nephrogenic Systemic Fibrosis?
Saab G, Abu-Alfa A. Are Patients with Moderate Renal Failure at Risk for Developing Nephrogenic Systemic Fibrosis? Radiology 2007, 244: 930-932. PMID: 17709844, DOI: 10.1148/radiol.2443070351.Peer-Reviewed Original Research
2003
Addition of sertraline to other therapies to reduce dialysis‐associated hypotension
BREWSTER UC, CIAMPI MA, ABU‐ALFA A, PERAZELLA MA. Addition of sertraline to other therapies to reduce dialysis‐associated hypotension. Nephrology 2003, 8: 296-301. PMID: 15012700, DOI: 10.1111/j.1440-1797.2003.00216.x.Peer-Reviewed Original ResearchConceptsDialysis-associated hypotensionCentral blood volumePeripheral vascular resistanceBlood pressureCardiac outputBlood volumeEnd-stage renal disease patientsInitiation of dialysisRenal disease patientsDiastolic blood pressureSystolic blood pressureEffects of sertralineTermination of dialysisAddition of sertralineUltrasound dilution techniqueVascular resistanceArterial pressureHaemodynamic measurementsDisease patientsPatientsControl phaseSertralineTherapyDialysisHypotension
2002
Observations on HIV-Associated Renal Disease in the Era of Highly Active Antiretroviral Therapy
Cosgrove CJ, Abu-Alfa AK, Perazella MA. Observations on HIV-Associated Renal Disease in the Era of Highly Active Antiretroviral Therapy. The American Journal Of The Medical Sciences 2002, 323: 102-106. PMID: 11863077, DOI: 10.1097/00000441-200202000-00009.Peer-Reviewed Original ResearchConceptsHIV-associated nephropathyActive antiretroviral therapySerum creatinineRenal functionRenal diseaseRenal outcomesAntiretroviral therapyViral loadRenal lesionsHighly Active Antiretroviral TherapyAngiotensin-converting enzyme inhibitorEffect of HAARTNon-HAART groupAdvanced renal failureInitiation of dialysisRenal function parametersStable renal functionVariety of lesionsHAART groupCD4 countHAART eraRenal evaluationRenal insufficiencyRenal ultrasoundBaseline characteristicsHemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine
Hoeben H, Abu-Alfa AK, Mahnensmith R, Perazella MA. Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine. American Journal Of Kidney Diseases 2002, 39: 102-107. PMID: 11774108, DOI: 10.1053/ajkd.2002.29887.Peer-Reviewed Original ResearchConceptsPeripheral vascular resistanceCentral blood volumeDialysis-associated hypotensionCardiac outputIntradialytic hypotensionIntradialytic hemodynamicsCool dialysateEnd-stage renal disease populationTermination of hemodialysisInitiation of hemodialysisMean arterial pressureRenal disease populationUltrasound dilution techniqueVascular resistanceHemodynamic stabilityArterial pressureBlood pressureUltrafiltration volumeDisease populationHypotensionBlood volumePatientsMidodrineHemodialysisHemodynamics
1998
Reduction in arteriovenous graft impairment: Results of a vascular access surveillance protocol
Cayco A, Abu-Alfa A, Mahnensmith R, Perazella M. Reduction in arteriovenous graft impairment: Results of a vascular access surveillance protocol. American Journal Of Kidney Diseases 1998, 32: 302-308. PMID: 9708617, DOI: 10.1053/ajkd.1998.v32.pm9708617.Peer-Reviewed Original ResearchConceptsDynamic venous pressureHistorical control groupVenous pressureArteriovenous graftsSurveillance protocolStudy groupBlood flow rateThrombosis rateControl groupSimilar historical control groupHemodialysis vascular accessSynthetic arteriovenous graftsLower thrombosis rateML/minGraft impairmentVenous stenosisHD sessionVascular accessVascular stenosisPatientsScreening testStenosisStudy periodFrustrating problemConsecutive readings