2015
Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model
Scarisbrick JJ, Prince HM, Vermeer MH, Quaglino P, Horwitz S, Porcu P, Stadler R, Wood GS, Beylot-Barry M, Pham-Ledard A, Foss F, Girardi M, Bagot M, Michel L, Battistella M, Guitart J, Kuzel TM, Martinez-Escala ME, Estrach T, Papadavid E, Antoniou C, Rigopoulos D, Nikolaou V, Sugaya M, Miyagaki T, Gniadecki R, Sanches JA, Cury-Martins J, Miyashiro D, Servitje O, Muniesa C, Berti E, Onida F, Corti L, Hodak E, Amitay-Laish I, Ortiz-Romero PL, Rodríguez-Peralto JL, Knobler R, Porkert S, Bauer W, Pimpinelli N, Grandi V, Cowan R, Rook A, Kim E, Pileri A, Patrizi A, Pujol RM, Wong H, Tyler K, Stranzenbach R, Querfeld C, Fava P, Maule M, Willemze R, Evison F, Morris S, Twigger R, Talpur R, Kim J, Ognibene G, Li S, Tavallaee M, Hoppe RT, Duvic M, Whittaker SJ, Kim YH. Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model. Journal Of Clinical Oncology 2015, 33: 3766-3773. PMID: 26438120, PMCID: PMC4979132, DOI: 10.1200/jco.2015.61.7142.Peer-Reviewed Original ResearchConceptsMF/Sézary syndromeAdvanced-stage MF/Sézary syndromeMedian overall survivalSézary syndromeIndependent prognostic markerOverall survivalPrognostic markerWorse survivalMycosis fungoidesAdvanced MF/SSSurvival rateAdvanced-stage mycosis fungoidesIdentical T-cell clonesStage IIB diseaseStage III diseaseStage IV diseaseSingle-center trialAdvanced-stage patientsIndependent prognostic valueSerum lactate dehydrogenasePrognostic index modelSpecific prognostic markersLarge cell transformationT cell clonesIIB disease
2014
Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells
Lewis JM, Bürgler CD, Fraser JA, Liao H, Golubets K, Kucher CL, Zhao PY, Filler RB, Tigelaar RE, Girardi M. Mechanisms of Chemical Cooperative Carcinogenesis by Epidermal Langerhans Cells. Journal Of Investigative Dermatology 2014, 135: 1405-1414. PMID: 25233073, PMCID: PMC4364923, DOI: 10.1038/jid.2014.411.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaLC-deficient miceLangerhans cellsPresence of LCCutaneous squamous cell carcinomaEpidermal Langerhans cellsMyeloid-derived cellsEnzyme CYP1B1Infundibular keratinocytesDendritic cellsCell carcinomaInvasive malignancyCutaneous carcinogenesisCarcinogenesis roleTobacco smokeLC precursorsMalignant transformationTumor progressionMetastatic potentialTumor susceptibilityMiceChemical carcinogenesisCarcinogenesisNeoplastic transformationLC expression
2012
Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma
Modi BG, Neustadter J, Binda E, Lewis J, Filler RB, Roberts SJ, Kwong BY, Reddy S, Overton JD, Galan A, Tigelaar R, Cai L, Fu P, Shlomchik M, Kaplan DH, Hayday A, Girardi M. Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma. Science 2012, 335: 104-108. PMID: 22223807, PMCID: PMC3753811, DOI: 10.1126/science.1211600.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsAryl Hydrocarbon HydroxylasesCarcinogensCarcinoma, Squamous CellCell Transformation, NeoplasticCells, CulturedCytochrome P-450 CYP1A1Cytochrome P-450 CYP1B1DNA DamageGenes, rasHumansKeratinocytesLangerhans CellsMiceMice, TransgenicSkin NeoplasmsT-LymphocytesConceptsLangerhans cellsDendritic cellsDMBA-induced DNA damageCutaneous chemical carcinogenesisEpidermal dendritic cellsLC-deficient miceT cell immunitySquamous cell carcinomaChemical carcinogenesisDMBA-transHras mutationsCell immunityCell carcinomaImmune cellsDNA damageTumor resistanceDMBAPrior incubationHuman keratinocytesCarcinogenesisUnderlying mechanismMicePotent carcinogenSkinPAH metabolism
2010
The contribution of Langerhans cells to cutaneous malignancy
Lewis J, Filler R, Smith DA, Golubets K, Girardi M. The contribution of Langerhans cells to cutaneous malignancy. Trends In Immunology 2010, 31: 460-466. PMID: 21071271, PMCID: PMC3753793, DOI: 10.1016/j.it.2010.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCell Transformation, NeoplasticHumansLangerhans CellsModels, ImmunologicalSkin NeoplasmsConceptsLangerhans cellsDendritic cellsRole of LCsIntraepidermal dendritic cellsAntigen-presenting cellsDC populationsCutaneous malignanciesImmunological organT cellsAdaptive immunitySkin cancerMalignant transformationEnvironmental exposuresUnique populationPotential roleCancerEpithelial tissuesCellsRecent studiesSkinMigratory changesMalignancyPathogenesisPopulationImmunity
2008
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nature Immunology 2008, 9: 146-154. PMID: 18176566, DOI: 10.1038/ni1556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Transformation, NeoplasticEpidermisHistocompatibility Antigens Class IImmunologic SurveillanceLangerhans CellsLigandsMiceMice, Inbred StrainsNK Cell Lectin-Like Receptor Subfamily KReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsT-LymphocytesUp-RegulationConceptsNKG2D ligandsImmune compartmentLangerhans cellsT cellsRAE-1Local immune compartmentIntraepithelial T cellsΑβ T cellsEpithelial infiltrationTissue immunosurveillanceGraft rejectionInflammatory lesionsReceptor NKG2DAcute changesLigand MICACytotoxic lymphocytesAcute upregulationImmunosurveillanceEarly phaseCarcinogenesisUpregulationPleiotropic effectsCellsNKG2DCarcinoma
2007
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature 2007, 445: 761-765. PMID: 17230190, DOI: 10.1038/nature05489.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisCarcinoma, Squamous CellCell LineCell Transformation, NeoplasticCrosses, GeneticFemaleGene Expression Regulation, NeoplasticGenes, rasHSP40 Heat-Shock ProteinsHumansKruppel-Like Transcription FactorsMaleMiceMice, Inbred C57BLMice, TransgenicMolecular Sequence DataPatched ReceptorsPatched-1 ReceptorPolymorphism, GeneticRas ProteinsReceptors, Cell SurfaceZinc Finger Protein Gli2ConceptsSquamous carcinomaTumor suppressor geneFVB/N miceSonic hedgehogSuppressor geneFVB/N strainBasal cell carcinomaPTCH geneSame target cellsCell lineage commitmentPatched geneHuman patched geneHost genetic backgroundClassical tumor suppressor geneCell carcinomaPtch alleleFVB miceN miceCarcinogen exposureC57BL/6 strainTumor typesLineage commitmentMouse homologueHybrid miceGenetic basis