2022
Sentinel Lymph Node Biopsy Positivity in Patients With Acral Lentiginous and Other Subtypes of Cutaneous Melanoma
Cheraghlou S, Ugwu N, Girardi M. Sentinel Lymph Node Biopsy Positivity in Patients With Acral Lentiginous and Other Subtypes of Cutaneous Melanoma. JAMA Dermatology 2022, 158: 51-58. PMID: 34878492, PMCID: PMC8655663, DOI: 10.1001/jamadermatol.2021.4812.Peer-Reviewed Original ResearchConceptsAcral lentiginous melanomaNational Cancer DatabaseClinical stage IBSLN positivityStage IBSentinel lymphCutaneous melanomaPositivity rateMalignant melanomaHigh riskSentinel lymph node statusAJCC Cancer Staging ManualClinical stage IRetrospective cohort studySignificant prognostic factorsLymph node statusCancer Staging ManualMultivariable logistic regressionHigher positivity rateAJCC clinical stageCohort studySLN statusPrognostic factorsSuch patientsStaging Manual
2021
A machine‐learning modified CART algorithm informs Merkel cell carcinoma prognosis
Cheraghlou S, Sadda P, Agogo GO, Girardi M. A machine‐learning modified CART algorithm informs Merkel cell carcinoma prognosis. Australasian Journal Of Dermatology 2021, 62: 323-330. PMID: 34028790, DOI: 10.1111/ajd.13624.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseMerkel cell carcinomaPositive lymph node countLymph node countPositive nodesDistant metastasisValidation cohortRare neuroendocrine skin cancerRetrospective cohort studyEnd Results registryLymph node biopsyLymph node metastasisThree-year survivalNeuroendocrine skin cancerNovel prognostic factorHigh mortality rateNode countAJCC groupsMCC stagingSEER cohortCohort studyMCC patientsNode biopsyPrognostic factorsNode metastasisAssociation of Treatment Facility Characteristics With Overall Survival After Mohs Micrographic Surgery for T1a-T2a Invasive Melanoma
Cheraghlou S, Christensen SR, Leffell DJ, Girardi M. Association of Treatment Facility Characteristics With Overall Survival After Mohs Micrographic Surgery for T1a-T2a Invasive Melanoma. JAMA Dermatology 2021, 157: 531-539. PMID: 33787836, PMCID: PMC8014201, DOI: 10.1001/jamadermatol.2021.0023.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryNational Cancer DatabaseTreatment facility characteristicsMicrographic surgeryInvasive melanomaCohort studyOverall survivalImproved long-term survivalLong-term patient survivalCox proportional hazards modelFacility characteristicsCancer-accredited facilitiesStudy of resectionRetrospective cohort studyMultivariable survival analysisWide local excisionHazard of deathTreatment of patientsLow-volume facilitiesProportional hazards modelEarly-stage melanomaFacility-level factorsLong-term survivalImproved survivalLocal excision
2019
Comparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma
Cheraghlou S, Christensen SR, Agogo GO, Girardi M. Comparison of Survival After Mohs Micrographic Surgery vs Wide Margin Excision for Early-Stage Invasive Melanoma. JAMA Dermatology 2019, 155: 1252-1259. PMID: 31553403, PMCID: PMC6764120, DOI: 10.1001/jamadermatol.2019.2890.Peer-Reviewed Original ResearchWide margin excisionMohs micrographic surgeryNational Cancer DatabaseOverall survivalInvasive melanomaStage IMargin excisionCancer DatabaseMicrographic surgeryCox proportional hazards regression survival analysisCox proportional hazards regression analysisCancer (AJCC) Cancer Staging ManualUse of MMSPropensity score-matched analysisProportional hazards regression analysisCancer-accredited facilitiesRetrospective cohort studyAmerican Joint CommitteeCancer Staging ManualHazards regression analysisCommon malignant neoplasmTreatment of melanomaRegression survival analysisComparison of survivalEligible patientsThe impact of facility characteristics on Merkel cell carcinoma outcomes: A retrospective cohort study
Cheraghlou S, Agogo GO, Girardi M. The impact of facility characteristics on Merkel cell carcinoma outcomes: A retrospective cohort study. Journal Of The American Academy Of Dermatology 2019, 89: 70-80. PMID: 31473294, DOI: 10.1016/j.jaad.2019.08.058.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaPropensity score-matched cohortDisease-specific survivalPatient survivalCase volumeRare neuroendocrine skin cancerTreatment of MCCVolume facilitiesFacility characteristicsLocal recurrence dataNational Cancer DatabaseRetrospective cohort studyRetrospective cohort analysisHigh-volume centersNeuroendocrine skin cancerAcademic affiliationFacility-level characteristicsMCC outcomesCohort studyExperienced centersRare malignancyNonacademic facilitiesCell carcinomaCancer DatabaseCohort analysisEvaluation of Lymph Node Ratio Association With Long-term Patient Survival After Surgery for Node-Positive Merkel Cell Carcinoma
Cheraghlou S, Agogo GO, Girardi M. Evaluation of Lymph Node Ratio Association With Long-term Patient Survival After Surgery for Node-Positive Merkel Cell Carcinoma. JAMA Dermatology 2019, 155: 803-811. PMID: 30825411, PMCID: PMC6583886, DOI: 10.1001/jamadermatol.2019.0267.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseMerkel cell carcinomaPositive lymph nodesDisease-specific survivalLymph nodesSEER registryEligible casesPatient survivalPatient counselingCell carcinomaPrognostic indicatorPopulation-based US cohortLong-term patient survivalAJCC N stagingCancer-accredited facilitiesAdjuvant radiation therapyRetrospective cohort studyAdjuvant chemoradiation therapyEnd Results registryTreatment planningHigh mortality rateSEER data setLNR statusTraditional TNMAdjuvant therapy