2010
The contribution of Langerhans cells to cutaneous malignancy
Lewis J, Filler R, Smith DA, Golubets K, Girardi M. The contribution of Langerhans cells to cutaneous malignancy. Trends In Immunology 2010, 31: 460-466. PMID: 21071271, PMCID: PMC3753793, DOI: 10.1016/j.it.2010.10.001.Peer-Reviewed Original ResearchConceptsLangerhans cellsDendritic cellsRole of LCsIntraepidermal dendritic cellsAntigen-presenting cellsDC populationsCutaneous malignanciesImmunological organT cellsAdaptive immunitySkin cancerMalignant transformationEnvironmental exposuresUnique populationPotential roleCancerEpithelial tissuesCellsRecent studiesSkinMigratory changesMalignancyPathogenesisPopulationImmunity
2009
CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets
Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ, Silva-Santos B. CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets. Nature Immunology 2009, 10: 427-436. PMID: 19270712, PMCID: PMC4167721, DOI: 10.1038/ni.1717.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD27 LigandCells, CulturedInterferon-gammaInterleukin-17Lymphoid Progenitor CellsLymphotoxin beta ReceptorMalaria, CerebralMiceMice, Inbred C57BLPlasmodium bergheiReceptors, Antigen, T-Cell, gamma-deltaThymus GlandT-Lymphocyte SubsetsTumor Necrosis Factor Receptor Superfamily, Member 7
2008
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells
Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells. Nature Genetics 2008, 40: 656-662. PMID: 18408721, PMCID: PMC4167720, DOI: 10.1038/ng.108.Peer-Reviewed Original ResearchCutaneous T cell lymphoma: translating immunobiology into therapeutic opportunities.
Berger CL, Heald P, Girardi M, Edelson RL. Cutaneous T cell lymphoma: translating immunobiology into therapeutic opportunities. Giornale Italiano Di Dermatologia E Venereologia 2008, 143: 43-54. PMID: 18833050.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAnimalsAntibodies, MonoclonalAntineoplastic Combined Chemotherapy ProtocolsApoptosisBexaroteneClone CellsCytokinesDendritic CellsDiphtheria ToxinGene Expression Regulation, NeoplasticHumansImmunophenotypingInterleukin-2Lymphoma, T-Cell, CutaneousMiceNeoplastic Stem CellsPhotopheresisPUVA TherapyRecombinant Fusion ProteinsTetrahydronaphthalenesT-Lymphocyte SubsetsT-Lymphocytes, RegulatoryConceptsCutaneous T-cell lymphomaSheep red blood cellsT-cell lymphomaNew therapeutic approachesBasic science techniquesRed blood cellsClinical featuresTherapeutic optionsT lymphocytesCell lymphomaTherapeutic approachesClinical practiceImmune systemMalignant cellsTherapeutic opportunitiesBlood cellsPatientsImmunobiologyDiseaseMolecular demonstrationCurrent understandingCellsLymphomaLymphocytesImmunologyAcute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M. Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis. Nature Immunology 2008, 9: 146-154. PMID: 18176566, DOI: 10.1038/ni1556.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Transformation, NeoplasticEpidermisHistocompatibility Antigens Class IImmunologic SurveillanceLangerhans CellsLigandsMiceMice, Inbred StrainsNK Cell Lectin-Like Receptor Subfamily KReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsT-LymphocytesUp-RegulationConceptsNKG2D ligandsImmune compartmentLangerhans cellsT cellsRAE-1Local immune compartmentIntraepithelial T cellsΑβ T cellsEpithelial infiltrationTissue immunosurveillanceGraft rejectionInflammatory lesionsReceptor NKG2DAcute changesLigand MICACytotoxic lymphocytesAcute upregulationImmunosurveillanceEarly phaseCarcinogenesisUpregulationPleiotropic effectsCellsNKG2DCarcinoma
2007
Cutaneous Perspectives on Adaptive Immunity
Girardi M. Cutaneous Perspectives on Adaptive Immunity. Clinical Reviews In Allergy & Immunology 2007, 33: 4-14. PMID: 18094943, DOI: 10.1007/s12016-007-0040-9.Peer-Reviewed Original ResearchConceptsAntigen-specific responsesAdaptive immunityAdaptive immune systemDendritic cellsEffector cellsImmunologic memoryTumor immunosurveillanceInflammatory diseasesT cellsImmune responseImmune systemMajor subsetEndothelial cellsSkinMicrobial defenseImmunocytesImmunityEfficient surveillanceCellsResponseImmunosurveillanceChemokinesCytokinesLymphocytesDamaging agents
2006
Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant
Lewis JM, Girardi M, Roberts SJ, D Barbee S, Hayday AC, Tigelaar RE. Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant. Nature Immunology 2006, 7: 843-850. PMID: 16829962, DOI: 10.1038/ni1363.Peer-Reviewed Original ResearchConceptsT cellsIntraepithelial lymphocytesT cell receptorMouse dendritic epidermal T-cellsOligoclonal T-cell receptorsDendritic epidermal T cellsEpidermal T cellsT cell repertoireT cell progenitorsCutaneous pathologyCell repertoireThymic stromaStromal determinantsLymphocyte repertoireCell receptorLymphocytesCell progenitorsHeritable defectsCellsIntraepithelialAgonistsMicePathologyPhysiological useStromaImmunosurveillance and Immunoregulation by γδ T Cells
Girardi M. Immunosurveillance and Immunoregulation by γδ T Cells. Journal Of Investigative Dermatology 2006, 126: 25-31. PMID: 16417214, DOI: 10.1038/sj.jid.5700003.Peer-Reviewed Original ResearchConceptsGammadelta T cellsT cell receptorT cellsGammadelta T-cell receptorΓδ T cellsCellular stressHuman diseasesAlphabeta heterodimersTCR diversityCutaneous functionImmunoregulatory activitySmall populationMutant miceEpithelial surfaceCellsHeterodimersVast majorityDiversityImmunosurveillanceImmunoregulation
2005
Immunosurveillance by γδ T Cells: Focus on the Murine System
Girardi M, Hayday AC. Immunosurveillance by γδ T Cells: Focus on the Murine System. Chemical Immunology And Allergy 2005, 86: 136-150. PMID: 15976492, DOI: 10.1159/000086658.Peer-Reviewed Original ResearchConceptsT cell subsetsCell subsetsT cellsDistinct T cell subsetsSpecific T cell subsetsT cell responsesΓδ T cellsGammadelta T cellsPhysiologic immune responseLymphoid cell typesImmune surveillanceImmune responseMouse modelCell responsesClinical settingMurine systemCell typesDifferent genetic backgroundsGenetic backgroundAssociationCell associationCellsInflammationImmunosurveillanceSpecific tissues
2004
Cutaneous biology of gammadelta T cells.
Girardi M. Cutaneous biology of gammadelta T cells. Advances In Dermatology 2004, 20: 203-15. PMID: 15544201.Peer-Reviewed Original ResearchConceptsGammadelta T cellsT cellsInappropriate inflammatory responseNoninfectious skin diseasesMajor disease categoriesMost T cellsCutaneous inflammationLymph nodesCutaneous neoplasmsCutaneous tumorsCutaneous diseaseInflammatory responseReceptor subtypesSkin diseasesDisease categoriesEpidermal barrierCutaneous biologyInflammationLaboratory animalsNeoplastic transformationTCR variabilityDiseaseEpithelial tissuesCellsRecent studies
2002
Efficient Tumor Antigen Loading of Dendritic Antigen Presenting Cells by Transimmunization
Girardi M, Berger C, Hanlon D, Edelson RL. Efficient Tumor Antigen Loading of Dendritic Antigen Presenting Cells by Transimmunization. Technology In Cancer Research & Treatment 2002, 1: 65-69. PMID: 12614179, DOI: 10.1177/153303460200100109.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaMalignant T cellsT cellsTumor antigen loadingAnti-tumor immunityManagement of patientsT-cell lymphomaAntigen presenting cellsDendritic cell differentiationDendritic cellsSelective immunotherapyPresenting cellsOnly FDATumor antigensCell lymphomaAntigen loadingTumor cellsKey cellular eventsTransimmunizationImmunotherapyPatientsCancerRecent findingsEfficient phagocytosisCells
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis
2000
Cutaneous T-cell lymphoma: pathogenesis and treatment.
Girardi M, Edelson RL. Cutaneous T-cell lymphoma: pathogenesis and treatment. Oncology 2000, 14: 1061-70; discussion 1070-4, 1076. PMID: 10929591.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaSkin immune systemImmune systemT cellsManagement of CTCLCutaneous T-cellMemory T cellsT helper cellsT-cell lymphomaSelective adhesion moleculeLymph nodesClinical spectrumPeripheral bloodCutaneous pathogensMajor subtypesPathogenesisAdhesion moleculesLymphomaDistinctive subsetTreatmentNormal functioningCellsBetter understandingImmunosurveillanceMalignancy
1999
Extracorporeal photochemotherapy in human and murine graft-versus-host disease
Girardi M, McNiff J, Heald P. Extracorporeal photochemotherapy in human and murine graft-versus-host disease. Journal Of Dermatological Science 1999, 19: 106-113. PMID: 10098701, DOI: 10.1016/s0923-1811(98)00066-8.Peer-Reviewed Original Research
1998
The αβ/γδ Lineage Decision
Hoffman E, Passoni L, Dudley E, Girardi M, Hayday A. The αβ/γδ Lineage Decision. Contemporary Immunology 1998, 367-396. DOI: 10.1007/978-1-4757-2778-4_19.Peer-Reviewed Original ResearchLineage decisionsΑβ T cellsΑβ T cell developmentΓδ cellsT cell receptorT cellsT cell developmentObligatory associationMolecular biologyCell typesSyk kinaseΓδ T cellsΑβ T cell receptorPolypeptide complexMajor histocompatibility complex moleculesDistinct T cellsCell-associated antigensProgenitor cellsHistocompatibility complex moleculesAntigen receptorIntrathymic precursorsAntigen specificityB cellsCellsAntigenic peptides