Oscar Colegio, MD, PhD

Associate Professor Adjunct - Dermatology

Departments & Organizations

Dermatology: Colegio Lab | Dermatologic Surgery: Cutaneous Oncology Program; Dermatologic Laser Surgery Program; Full Body Skin Exams for Organ Transplant Recipients | Medical Dermatology

Experimental Pathology Graduate Program

Transplantation Center

Yale Cancer Center: Cancer Immunology

Office of Cooperative Research


Oscar R. Colegio, MD, PhD, is an Associate Professor of Dermatology, Pathology and Surgery at Yale School of Medicine where his clinical practice and research is focused on immunodeficiency-associated skin cancers and skin disorders associated with solid organ transplantation. His research has centered on defining the role of immune cells called macrophages in tumor progression. The focus of these studies has been to identify pathways of tumorigenesis critical to a variety of murine tumor types including lung carcinoma, melanoma, colon carcinoma and cutaneous squamous cell carcinoma. Parallel studies in identifying tumor-promoting pathways induced by infiltrating macrophages in human squamous cell carcinomas from immunosuppressed vs non-immunosuppressed patients is the current focus of the lab.

Dr. Colegio was a Scholar of the Yale Center for Clinical Investigation and was supported by the Yale SPORE in Skin Cancer and the Dermatology Foundation. He is currently funded through the National Cancer Institute. Dr. Colegio is a member of several professional organizations related to his clinical and research interests. He is on the board of directors of the International Transplant Skin Cancer Collaborative, where he serves as the Director of the Committee for Research.

Dr. Colegio is a graduate of The University of Texas, where he earned a BS in Pharmacy in 1995, and of Yale University where he earned a PhD in Cell Biology in 2003 and an MD, with election to Alpha Omega Alpha, in 2004. He completed an Internship in Internal Medicine and a Residency in Dermatology at Yale-New Haven Hospital during which time he was awarded the Hugh L. Dwyer Award for clinical excellence.

Education & Training

MD Yale University School of Medicine (2004)
PhD Yale University (2003)
BS University of Texas at Austin (1995)
Postdoctoral Fellow Yale
Resident Yale
Intern Yale

Honors & Recognition

  • Young Investigator AwardAmerican Academy of Dermatology (2017)

  • Young Physician-Scientist AwardAmerican Society for Clinical Investigation (2015)

  • Hugh Dwyer Award for Clinical ExcellenceYale New Haven Hospital (2008)

  • Alpha Omega Alpha (2004)

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Contact Info

Oscar Colegio, MD, PhD
Patient Care Locations
Yale Dermatology AssociatesDoctors Building
2 Church Street South, Ste 305

New Haven, CT 06519
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Yale Transplant Dermatology ClinicYale Physicians Building
800 Howard Avenue, Ste 4th Floor

New Haven, CT 06519
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Office Location
Laboratory OfficeHunter Building
15 York Street, Ste Suite 603b

New Haven, CT 06510
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Mailing Address
Dermatology333 Cedar Street, LMP 5040
PO Box 208059

New Haven, CT 06520-8059

Colegio Lab

Tumor-associated Macrophages in Human Melanoma

Metastatic melanoma with macrophages stained in brown and the inflammasome protein NLRC4 stained in fuschia.

Tumor-associated Macrophages Lung Carcinoma

Lung carcinoma, highlighting tumor-associated macrophages in yellow.