Gail D'Onofrio, MD, MS

Professor of Emergency Medicine; Chair, Department of Emergency Medicine

Departments & Organizations

Addiction Medicine Fellowship Program

Emergency Medicine: Drug use, Addiction, and HIV Research Scholars (DAHRS) | ED-Initiated Buprenorphine | Project Assert | SBIRT for Alcohol and Other Drug Problems

Program in Addiction Medicine

SBIRT Training in Yale Residency Programs

Yale Medicine

Office of Cooperative Research


Dr. D’Onofrio is Professor and the Inaugural Chair of the Department of Emergency Medicine at the Yale School of Medicine (2009) and Physician-in Chief of Emergency Services at Yale-New Haven Hospital EDs with an annual census of approximately 180,000 patients. She is boarded in emergency and addiction medicine.  Dr. D’Onofrio has extensive experience as a leader, researcher, mentor and educator, and is internationally known for her work in alcohol and other substance use disorders (SUDs) as well as for her research on gender variations in women with ischemic heart disease.   Her work (JAMA, 2015) demonstrating that ED-initiated buprenorphine increases engagement in addiction treatment for individuals with OUD, has changed clinical practice, receiving multiple science awards, including awards from the Hazelden Betty Ford Foundation and the Clinical Research Forum.  Dr. D’Onofrio has a long track record of mentoring physician scientists in independent research careers. She is the PI of a NIDA K12 establishing the Yale Drug Use, Addiction and HIV Research Scholars (Yale-DAHRS) program, a Mentored Career Development Program with focused training in prevention and treatment of drug use, addiction, and HIV in general medical settings with scholars in Medicine, Emergency Medicine (EM), Pediatrics, Obstetrics and Gynecology, and Pulmonary Critical Care; and she has mentored numerous EM faculty.  She has received multiple awards including Excellence in Mentoring award from the Association for Medical Education and Research in Substance Abuse (AMERSA 2008), Advancing Women in Emergency Medicine award from the Society of Academic Emergency Medicine (SAEM 2016) and the Academy for Women in Academic Emergency Medicine (AWAEM) Outstanding Department Award for the advancement of women (SAEM 2018). Dr. D’Onofrio is a founding Board member of the Board of Addiction Medicine recently recognized by ABMS as a Specialty, Sub-specialty.  An advocate for individuals with SUD, she is one of the architects of Connecticut Governor’s Strategic Plan to Reduce Opioid Deaths, working with multiple agencies regionally and nationally to change policies and introduce interventions to combat the opioid crisis.

Education & Training

MD Boston University School of Medicine (1987)
MS Boston University (1975)
Resident Boston City Hospital
Board Certification AB of Emergency Medicine, Emergency Medicine (1992, recertified: 2011)

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Contact Info

Gail D'Onofrio, MD, MS
Patient Care Location
Adult Emergency DepartmentYale New Haven Hospital
20 York Street, Ste Pavilion 218

New Haven, CT 06510
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Mailing Address
Emergency MedicineYale School of Medicine
464 Congress Ave., Suite 260

New Haven, CT 06519-1315
SAEM Pulse Cover article: "Physician at the Forefront" an interview with Gail D'Onofrio

Dr. Gail D'Onofrio is featured in SAEM Pulse, the magazine of the Society for Academic Emergency Medicine, for her groundbreaking research on ED-Initiated Treatment for Opioid Use Disorder