Daniel DiMaio, MD, PhD

Waldemar Von Zedtwitz Professor of Genetics and Professor of Molecular Biophysics and Biochemistry and of Therapeutic Radiology; Deputy Director, Yale Cancer Center

Departments & Organizations


Molecular Biophysics and Biochemistry

Therapeutic Radiology: Radiobiology

Center for RNA Science and Medicine

Dean's Workshops

HPV Working Group (Niccolai Lab)

Molecular Virology: Virology Laboratories

Yale Cancer Center: K12 Calabresi Immuno-Oncology Training Program (IOTP) | Virus and Other Infection-associated Cancers | Yale CTAP

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) | Microbiology | Molecular Cell Biology, Genetics and Development

Office of Cooperative Research


The DiMaio laboratory is studying the molecular mechanisms of how two groups of tumor viruses, human papillomaviruses and polyomaviruses, enter cells, with a particular focus on identifying the cellular proteins that mediate virus entry and intracellular trafficking and determining their molecular mechanisms of action. In addition, it is using viral transmembrane proteins as a basis to develop a class of artificial small transmembrane proteins with a variety of biological activities, including the ability to form tumors and confer resistance to HIV infection. Some of these proteins are the simplest proteins ever described and their study will reveal new features of protein action and the basis for specificity in protein-protein interactions.

Education & Training

PhD Johns Hopkins University (1981)
MD Johns Hopkins University (1978)
BS Yale University, Biology (1974)

Honors & Recognition

  • Member, Connecticut Academy of Science and Engineering (2014)

  • Honorary ProfessorUniversity College London (2012)

  • Fellow, American Association for the Advancement of Science (2003)

  • Graduate Mentoring Award in the Natural SciencesYale University Graduate School of Arts and Sciences (2001)

  • Fellow, American Academy of Microbiology (2000)

  • Member, American Society for Clinical Investigation (1993)

  • MERIT AwardNational Institutes of Health (1992)

  • Mallinckrodt Scholar Award (1983)

Professional Service

  • Yale University (2014 - Present) Director, Division of Biological Sciences

  • Board of Scientific Advisors, National Cancer Institute (2012 - Present)

  • American Society for Microbiology (1998 - 1999) Chairman, Division S (DNA viruses)

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Contact Info

Daniel DiMaio, MD, PhD
Mailing Address
GeneticsSHM I-141B, P.O. Box 208005
New Haven, CT 06520-8005

DiMaio Lab