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Gail D’Onofrio MD, MS

Professor and founding Chair of the Department of Emergency Medicine (DEM) at Yale University School of Medicine and Physician-in Chief of the Yale-New Haven Hospital Emergency Department, Dr. Gail D’Onofrio is known nationally and internationally for her work as an independent investigator in drug and alcohol research. She is a recognized leader in Emergency Medicine and has participated in many NIH panels and on review committees, including the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Heart, Lung and Blood Institute (NHLBI). As a mentor, she has extensive experience cultivating the careers of junior faculty, residents, and students. Her leadership, mentoring and administrative skills, along with her expertise as a researcher, bring considerable strengths to the DAHRS program.

Dr. D’Onofrio has served as a Principal Investigator (PI) on numerous federally funded grants and has a significant track record of extramural funding and peer-reviewed publications. In April, 2015, the results of her NIDA funded study for opioid dependent emergency department (ED) patients were published in JAMA, the Journal of the American Medical Association ( The study tested models of intervention, including the initiation of pharmacological treatment with buprenorphine/naloxone in the ED with primary care office-based follow-up. Her findings represent a paradigm shift, where physicians screen and initiate treatment for patients with chronic opioid dependence, similar to initiating treatment for other chronic diseases such as hypertension, diabetes and asthma, and refer for ongoing medical management. Prior publications have appeared in other high impact journals including the New England Journal of Medicine, Annals of Emergency Medicine, Academic Emergency Medicine, Academic Medicine, and Substance Abuse. As a PI, Dr. D’Onofrio also conducted two clinical trials funded by NIAAA, examining the efficacy of emergency practitioner performed brief interventions for hazardous and harmful ED drinkers, demonstrating that emergency practitioners can perform brief interventions in real world settings that significantly reduce alcohol consumption. Currently, Dr. D’Onofrio is the PI on a training grant funded by the Substance Abuse and Mental Health Services Administration, designed to train physicians, medical students, nurses, social workers and counselors, about screening, brief intervention and referral. Thus, she has the experience in proposal writing, research design, implementation, analysis and publication of large federally funded grants to assist with the complexity of projects that the Scholars may pursue.

In 2002, Dr. D’Onofrio completed the prestigious Hedwig van Ameringen Executive Leadership in Academic Medicine program, a fellowship for women faculty, representing and sponsored by the Dean of the Yale University School of Medicine. She was integral in the development of Emergency Medicine as the 28th Department in the Yale School of Medicine and she became its founding Chair in July of 2009. She is currently one of only a few female chairs of academic emergency departments in the United States. Drawing from experiences from her many career accomplishments, Dr. D’Onofrio has personally mentored many research faculty and has been instrumental in their obtaining independent research funding. Under her leadership, the level of extramural emergency medicine research funding in the DEM has increased significantly. She has received numerous awards for her leadership including the coveted Association of Medical Education and Research in Substance Abuse (AMERSA) mentoring award. In addition, she reviews grant applications for the Yale Center for Clinical Investigation and is an adjunct faculty member as well as an Advisory Committee member for the Yale Robert Woods Johnson Foundation-Clinical Scholars Program.