2021
Real-world Cardiovascular Outcomes Associated With Degarelix vs Leuprolide for Prostate Cancer Treatment
Wallach JD, Deng Y, McCoy RG, Dhruva SS, Herrin J, Berkowitz A, Polley EC, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Shah ND, Ross JS, Lyon TD. Real-world Cardiovascular Outcomes Associated With Degarelix vs Leuprolide for Prostate Cancer Treatment. JAMA Network Open 2021, 4: e2130587. PMID: 34677594, PMCID: PMC8536955, DOI: 10.1001/jamanetworkopen.2021.30587.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsSecondary end pointsMyocardial infarctionClinical trialsCardiovascular diseaseProstate cancerCardiovascular eventsEnd pointRisk of MACELarge US administrative claims databasePropensity-matched cohort studyUS administrative claims databasePropensity score-matched patientsAdverse cardiovascular eventsPrimary end pointAdministrative claims databaseProportional hazards regressionRandomized clinical trialsAdministrative claims dataTrial eligibility criteriaMedicare Advantage beneficiariesProstate cancer treatmentReal-world evidenceElectronic health recordsCardiovascular outcomes
2016
Adoption of new agents and changes in treatment patterns for hepatitis C: 2010-2014.
Yao X, Sangaralingham LR, Ross JS, Shah ND, Talwalkar JA. Adoption of new agents and changes in treatment patterns for hepatitis C: 2010-2014. The American Journal Of Managed Care 2016, 22: e224-32. PMID: 27355910.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiviral AgentsDatabases, FactualDrug Therapy, CombinationFemaleHealth Care CostsHepacivirusHepatitis C, ChronicHumansInsurance Claim ReviewInterferonsLogistic ModelsMaleMiddle AgedOligopeptidesPredictive Value of TestsRetrospective StudiesRibavirinSofosbuvirTreatment OutcomeUnited StatesConceptsTreatment ratesNew medicationsRetrospective analysisHepatitis C virus medicationsOptum Labs Data WarehouseUS commercial insurance databaseLedipasvir/sofosbuvirMedian OOP costsNew HCV medicationsInterferon/ribavirinInterferon-based regimensCommercial insurance databaseAdministrative claims dataChronic HCVLiver transplantElderly patientsHCV medicationsHepatitis CNew regimensLiver diseaseTreatment patternsInsurance databaseUrgent treatmentPrimary treatmentClaims data