2020
Clinical Outcomes With Beta-Blocker Use in Patients With Recent History of Myocardial Infarction
Jackevicius CA, Krumholz HM, Ross JS, Koh M, Chong A, Austin PC, Stukel TA, Azizi P, Ko DT. Clinical Outcomes With Beta-Blocker Use in Patients With Recent History of Myocardial Infarction. Canadian Journal Of Cardiology 2020, 36: 1633-1640. PMID: 32416066, DOI: 10.1016/j.cjca.2020.01.024.Peer-Reviewed Original ResearchConceptsPrior myocardial infarctionMyocardial infarctionStable patientsPopulation-based observational studyAngina 1 yearDeath/hospitalizationHistory of revascularisationBeta-blocker useMajor cardiovascular eventsHospital discharge diagnosisUse of BBsIndividual end pointsContemporary clinical trialsYears of ageCardiovascular eventsIndex dateCohort studyComposite outcomeBB useHeart failureMedian agePrimary outcomeClinical outcomesAtrial fibrillationDischarge diagnosis
2019
Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults
Sobieraj DM, Martinez BK, Hernandez AV, Coleman CI, Ross JS, Berg KM, Steffens DC, Baker WL. Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults. Journal Of The American Geriatrics Society 2019, 67: 1571-1581. PMID: 31140587, DOI: 10.1111/jgs.15966.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsMajor depressive disorderOverall adverse eventsAdverse eventsYears of ageStudy withdrawalAcute phaseReuptake inhibitorsObservational studyAdverse effectsChoice of antidepressantSerious adverse eventsAcute treatment phaseNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsSpecific adverse eventsComparative long-term studiesNonpharmacologic therapiesContinuation treatmentPatients 65Pharmacologic treatmentQTc prolongationMore fallsOutpatient setting
2017
Hospital-Readmission Risk — Isolating Hospital Effects from Patient Effects
Krumholz HM, Wang K, Lin Z, Dharmarajan K, Horwitz LI, Ross JS, Drye EE, Bernheim SM, Normand ST. Hospital-Readmission Risk — Isolating Hospital Effects from Patient Effects. New England Journal Of Medicine 2017, 377: 1055-1064. PMID: 28902587, PMCID: PMC5671772, DOI: 10.1056/nejmsa1702321.Peer-Reviewed Original ResearchConceptsRisk-standardized readmission ratesReadmission ratesObserved readmission ratesSimilar diagnosesHospital effectsDifferent hospitalsHospital readmission performanceRate of readmissionHospital readmission ratesLower readmission ratesStudy sampleYears of ageSignificant differencesMultiple admissionsReadmission outcomesOnly significant differencePatient effectsSame patientMedicare recipientsPatientsReadmission performanceRisk-standardized hospital readmission ratesHospitalHospital qualityQuartile
2016
Participation of the elderly, women, and minorities in pivotal trials supporting 2011–2013 U.S. Food and Drug Administration approvals
Downing NS, Shah ND, Neiman JH, Aminawung JA, Krumholz HM, Ross JS. Participation of the elderly, women, and minorities in pivotal trials supporting 2011–2013 U.S. Food and Drug Administration approvals. Trials 2016, 17: 199. PMID: 27079511, PMCID: PMC4832528, DOI: 10.1186/s13063-016-1322-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedClinical Trials as TopicCross-Sectional StudiesDatabases, FactualDrug ApprovalEthnicityFemaleHealth Status DisparitiesHealthcare DisparitiesHumansMaleMiddle AgedMinority GroupsPatient SelectionSex FactorsTime FactorsUnited StatesUnited States Food and Drug AdministrationConceptsSubgroup efficacy analysesPivotal trialsEfficacy analysisNovel therapeuticsSubgroup analysisTrial participantsU.S. FoodMean proportionAvailable FDA documentsCross-sectional studyDrug Administration approvalBasis of approvalYears of ageTrial patientsElderly patientsMedian ageBlack patientsAsian patientsAdministration approvalClinical studiesFDA reviewersPatientsHispanic participantsTrialsDemographic characteristics
2014
Physician clinical management strategies and reasoning: a cross-sectional survey using clinical vignettes of eight common medical admissions
Smith KL, Ashburn S, Aminawung JA, Mann M, Ross JS. Physician clinical management strategies and reasoning: a cross-sectional survey using clinical vignettes of eight common medical admissions. BMC Health Services Research 2014, 14: 176. PMID: 24742131, PMCID: PMC4021187, DOI: 10.1186/1472-6963-14-176.Peer-Reviewed Original ResearchConceptsClinical management strategiesMedical admissionsGuideline supportCross-sectional surveyClinical vignettesEvidence-based careAvoidance of careYears of ageLocal practice patternsInternal medicine programsSupportive evidenceResultsOur samplePractice patternsPhysicians' likelihoodClinical scenariosAdmissionBrief clinical scenariosDiagnostic testsPhysiciansClinical responsibilitiesMedicine programsStrong evidenceManagement strategiesEvidence disseminationCare
2013
For-profit hospital ownership status and use of brachytherapy after breast-conserving surgery
Sen S, Soulos PR, Herrin J, Roberts KB, Yu JB, Lesnikoski BA, Ross JS, Krumholz HM, Gross CP. For-profit hospital ownership status and use of brachytherapy after breast-conserving surgery. Surgery 2013, 155: 776-788. PMID: 24787104, PMCID: PMC4008843, DOI: 10.1016/j.surg.2013.12.009.Peer-Reviewed Original ResearchConceptsHospital ownership statusBreast-conserving operationsBreast-conserving surgeryUse of brachytherapyRadiation therapyOperative careBreast cancerMedicare beneficiariesOverall useReceipt of brachytherapyAdjuvant radiation therapyInvasive breast cancerFemale Medicare beneficiariesGreater overall useYears of ageShort life expectancyRetrospective studyRT modalityProfit hospitalsExpensive modalityOlder womenBrachytherapy useBreast brachytherapyHospitalBrachytherapy
2011
Assessing the Impact of Screening Colonoscopy on Mortality in the Medicare Population
Gross CP, Soulos PR, Ross JS, Cramer LD, Guerrero C, Tinetti ME, Braithwaite RS. Assessing the Impact of Screening Colonoscopy on Mortality in the Medicare Population. Journal Of General Internal Medicine 2011, 26: 1441-1449. PMID: 21842323, PMCID: PMC3235614, DOI: 10.1007/s11606-011-1816-4.Peer-Reviewed Original ResearchConceptsColorectal cancerStrata of sexYears of ageShort life expectancyDesignRetrospective studyResultsIncreasing ageWomen 75Greater comorbidityOlder patientsScreening colonoscopyComorbiditiesRoutine screeningMedicare populationMortality ratePatientsAge groupsEffectiveness of SCMortalityLife expectancyWomenAgeMenColonoscopySexYearsPrevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization
Roumie CL, Ofner S, Ross JS, Arling G, Williams LS, Ordin DL, Bravata DM. Prevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization. Circulation Cardiovascular Quality And Outcomes 2011, 4: 399-407. PMID: 21693725, PMCID: PMC3140571, DOI: 10.1161/circoutcomes.110.959809.Peer-Reviewed Original ResearchConceptsBP controlBlood pressureIschemic strokeStroke patientsLower oddsAcute ischemic stroke hospitalizationsInadequate blood pressure controlHistory of hypertensionPercent of patientsBlood pressure controlElevated blood pressureSystolic blood pressureIschemic stroke hospitalizationsYears of ageHypertension careHypertension historyDischarge dispositionStroke eventsIndex eventStroke hospitalizationsBlack raceBP valuesCardiovascular diseaseNational guidelinesPatients
2010
Use of Administrative Claims Models to Assess 30-Day Mortality Among Veterans Health Administration Hospitals
Ross JS, Maynard C, Krumholz HM, Sun H, Rumsfeld JS, Normand SL, Wang Y, Fihn SD. Use of Administrative Claims Models to Assess 30-Day Mortality Among Veterans Health Administration Hospitals. Medical Care 2010, 48: 652-658. PMID: 20548253, PMCID: PMC3020977, DOI: 10.1097/mlr.0b013e3181dbe35d.Peer-Reviewed Original ResearchConceptsStatistical modelAcute myocardial infarctionVeterans Health Administration hospitalsVHA hospitalsHeart failurePneumonia hospitalizationsC-statisticNon-federal hospitalsMedian numberModest heterogeneityAdministration HospitalAdministrative claims dataService Medicare beneficiariesYears of age