2020
Changes in Functional Status and Health-Related Quality of Life in Older Adults After Surgical, Interventional, or Medical Management of Acute Myocardial Infarction
Mori M, Djulbegovic M, Hajduk A, Holland ML, Krumholz HM, Chaudhry SI. Changes in Functional Status and Health-Related Quality of Life in Older Adults After Surgical, Interventional, or Medical Management of Acute Myocardial Infarction. Seminars In Thoracic And Cardiovascular Surgery 2020, 33: 72-81. PMID: 32439546, PMCID: PMC7983308, DOI: 10.1053/j.semtcvs.2020.05.001.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCoronary Artery DiseaseFunctional StatusHumansMyocardial InfarctionPercutaneous Coronary InterventionQuality of LifeRisk FactorsTreatment OutcomeConceptsCoronary artery bypass graftPercutaneous coronary interventionAcute myocardial infarctionPhysical component scaleMedical managementFunctional statusOlder patientsMyocardial infarctionArtery bypass graftHealth-related qualityAge 75 yearsPatient-centered outcomesRisk of declinePredictors of declineQuality of lifeUnadjusted incidenceCoronary interventionADL declineCardiac surgeryMedical therapyBypass graftSF-12Multivariable modelHRQoLPatients
2019
Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study.
Dodson JA, Hajduk AM, Geda M, Krumholz HM, Murphy TE, Tsang S, Tinetti ME, Nanna MG, McNamara R, Gill TM, Chaudhry SI. Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study. Annals Of Internal Medicine 2019, 172: 12-21. PMID: 31816630, PMCID: PMC7695040, DOI: 10.7326/m19-0974.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute DiseaseAgedAged, 80 and overFemaleHospitalizationHumansMaleMyocardial InfarctionPrognosisProspective StudiesRisk FactorsUnited StatesConceptsAcute myocardial infarctionPost-AMI mortalityFunctional impairmentOlder adultsCohort studyMean ageMyocardial infarctionPatient-reported health statusNet reclassification improvement indexProspective cohort studyParticipants' mean ageFinal risk modelMobility impairmentsGood discriminatory abilityRisk modelChart reviewHospital dischargePrognostic utilityBlood InstituteClinical variablesNational HeartHigh prevalenceHealth statusMortalityYounger counterpartsAcute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
Dodson JA, Hajduk A, Curtis J, Geda M, Krumholz HM, Song X, Tsang S, Blaum C, Miller P, Parikh CR, Chaudhry SI. Acute Kidney Injury Among Older Patients Undergoing Coronary Angiography for Acute Myocardial Infarction: The SILVER-AMI Study. The American Journal Of Medicine 2019, 132: e817-e826. PMID: 31170374, PMCID: PMC6891160, DOI: 10.1016/j.amjmed.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute Kidney InjuryAge FactorsAgedAged, 80 and overCohort StudiesCoronary AngiographyDatabases, FactualFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansKaplan-Meier EstimateLogistic ModelsMaleMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsAcute kidney injuryAcute myocardial infarctionAge-related conditionsKidney injuryBody mass indexCoronary angiographyRisk factorsMyocardial infarctionOlder patientsMean ageAcute kidney injury risk factorsAcute Myocardial Infarction StudyAcute myocardial infarction cohortOlder adultsGlobal Outcomes criteriaMyocardial Infarction StudyInjury risk factorsParticipants' mean ageSILVER-AMI StudyMultivariable adjustmentComorbid diseasesHeart failureIndependent predictorsGeriatric conditionsMass index
2012
Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. American Heart Journal 2012, 163: 790-796. PMID: 22607856, PMCID: PMC3359897, DOI: 10.1016/j.ahj.2012.02.024.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAngioplasty, Balloon, CoronaryAttitude to HealthCardiac CatheterizationCoronary AngiographyDepressionElectrocardiographyFemaleFollow-Up StudiesHealth SurveysHumansIncidenceIndependent LivingMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPhysical FitnessPoisson DistributionPredictive Value of TestsQuality of LifeRegistriesRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvivorsTime FactorsTranslational Research, BiomedicalConceptsAcute myocardial infarctionPhysical function declineFunction declinePhysical functionMyocardial infarctionHealth statusEuroQol-5DUninsured statusTime of AMIShort Form-12 Physical Component ScoreIndependence lossEnd-stage renal diseasePost-acute myocardial infarctionCardiac rehabilitation referralPhysical component scorePatients' health statusQuality of lifePoisson regression modelsTRIUMPH registryRehabilitation referralRenal diseaseNonwhite raceFemale sexRisk factorsUnmarried status
2011
Trends in Comorbidity, Disability, and Polypharmacy in Heart Failure
Wong CY, Chaudhry SI, Desai MM, Krumholz HM. Trends in Comorbidity, Disability, and Polypharmacy in Heart Failure. The American Journal Of Medicine 2011, 124: 136-143. PMID: 21295193, PMCID: PMC3237399, DOI: 10.1016/j.amjmed.2010.08.017.Peer-Reviewed Original ResearchConceptsProportion of patientsHeart failureSelf-reported heart failureHeart failure populationComorbid chronic conditionsNumber of comorbiditiesNutrition Examination SurveyCare of patientsPrevalence of disabilityPhenotype of patientsComplexity of patientsMedication useRecent patientsFunctional disabilityExamination SurveyFailure populationPhysical functionPrescription medicationsPatient preferencesChronic conditionsNational HealthPatient's abilityComorbiditiesPatientsOlder individuals
2008
Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure
McNamara R, Austin B, Wang Y, Smith G, Vaccarine V, Krumholz H. Systolic Function as a Predictor of Mortality and Quality of Life in Long‐term Survivors with Heart Failure. Clinical Cardiology 2008, 31: 119-124. PMID: 18383045, PMCID: PMC6653267, DOI: 10.1002/clc.20118.Peer-Reviewed Original ResearchConceptsQuality of lifeEjection fractionHeart failureLong-term survivorsFunctional declineSystolic functionKansas City Cardiomyopathy Questionnaire scoreModest survival advantageReduced ejection fractionDaily living scoreDisease-related qualityPredictors of mortalityHeart failure patientsClinical summary scoreLong-term survivalHigh mortality rateKCCQ scoresRenal insufficiencyFailure patientsLiving scoreDiabetes mellitusOverall mortalityPrimary outcomeLimitation scoresQOL scores
2007
Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction
Garavalia LS, Decker C, Reid KJ, Lichtman JH, Parashar S, Vaccarino V, Krumholz HM, Spertus JA. Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction. Journal Of Women's Health 2007, 16: 93-101. PMID: 17324100, DOI: 10.1089/jwh.2006.m073.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHealth statusNon-ST segment elevation myocardial infarctionRisk-adjusted multivariable modelsSegment elevation myocardial infarctionChronic lung diseaseElevation myocardial infarctionWorse health statusPoor physical functioningQuality of lifeResidual anginaCoronary revascularizationHeart failureLung diseaseMI patientsPhysical functionMultivariable PoissonMultivariable modelPhysical functioningEarly recoveryGreater prevalenceInfarctionPatientsAdditional treatmentWomen
2006
Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery
Parikh CR, Coca SG, Smith GL, Vaccarino V, Krumholz HM. Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery. JAMA Internal Medicine 2006, 166: 2014-2019. PMID: 17030836, DOI: 10.1001/archinte.166.18.2014.Peer-Reviewed Original ResearchConceptsSevere chronic kidney diseaseChronic kidney diseasePhysical functionMH scorePF scoresKidney diseaseMedical Outcomes Trust Short FormAdvanced chronic kidney diseaseCoronary artery bypass surgeryLife outcomesCoronary artery bypassPrimary end pointArtery bypass surgeryHealth-related qualityCoronary artery diseaseMH subscalesArtery bypassCKD stageBypass surgeryArtery diseaseHealth SurveyMean changeStage 0Mean decreaseCABGTime Course of Depression and Outcome of Myocardial Infarction
Parashar S, Rumsfeld JS, Spertus JA, Reid KJ, Wenger NK, Krumholz HM, Amin A, Weintraub WS, Lichtman J, Dawood N, Vaccarino V. Time Course of Depression and Outcome of Myocardial Infarction. JAMA Internal Medicine 2006, 166: 2035-2043. PMID: 17030839, DOI: 10.1001/archinte.166.18.2035.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAngina, UnstableAntidepressive AgentsDepressionFemaleHealth StatusHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOutcome Assessment, Health CarePatient ReadmissionPrognosisProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsUnited StatesConceptsPatient Health QuestionnaireMyocardial infarctionDepressive symptomsPrognostic importanceWorse outcomesPersistent depressionHealth statusAdjusted hazard ratioAcute myocardial infarctionCorresponding odds ratiosCategories of depressionMore physical limitationsTime courseFrequent anginaHigher rehospitalizationCause rehospitalizationNondepressed patientsProspective registryHazard ratioOdds ratioHealth QuestionnaireMortality rateDisease severityRehospitalizationFirst monthPerceived control and change in physical functioning after coronary artery bypass grafting: A prospective study
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study. International Journal Of Behavioral Medicine 2006, 13: 229-236. PMID: 17078773, DOI: 10.1207/s15327558ijbm1303_6.Peer-Reviewed Original ResearchConceptsHealth-related controlCoronary artery bypassPhysical functioningArtery bypassHospital dischargeIndependent predictorsProspective studyCaucasian manMean ageSignificant associationOne-way analysisMeasure outcomesBypassIntervention effortsMonthsWeeksX timeSignificant interactionBeneficial impactPositive changesPatientsSocial support and change in health-related quality of life 6 months after coronary artery bypass grafting
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Social support and change in health-related quality of life 6 months after coronary artery bypass grafting. Journal Of Psychosomatic Research 2006, 60: 185-193. PMID: 16439272, DOI: 10.1016/j.jpsychores.2005.06.080.Peer-Reviewed Original ResearchConceptsHealth-related qualityCoronary artery bypassPhysical functioningMental healthArtery bypassSF-36 subscale scoresAge 65.7 yearsLife 6 monthsStepwise linear regression analysisSocial supportFirst CABGHospital dischargeProspective cohortClinical presentationLinear regression analysisInstrumental supportChange scoresSubscale scoresMonthsSocial support variablesRegression analysisBypassHealthIntervention effortsEmotional support
2004
Association Between Functional Status and Use and Effectiveness of Beta‐Blocker Prophylaxis in Elderly Survivors of Acute Myocardial Infarction
Vitagliano G, Curtis JP, Concato J, Feinstein AR, Radford MJ, Krumholz HM. Association Between Functional Status and Use and Effectiveness of Beta‐Blocker Prophylaxis in Elderly Survivors of Acute Myocardial Infarction. Journal Of The American Geriatrics Society 2004, 52: 495-501. PMID: 15066062, DOI: 10.1111/j.1532-5415.2004.52153.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAcute DiseaseAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overCross-Sectional StudiesDrug PrescriptionsDrug UtilizationFemaleGeriatric AssessmentHumansLogistic ModelsMaleMultivariate AnalysisMyocardial InfarctionPatient DischargePatient SelectionPractice Patterns, Physicians'Proportional Hazards ModelsRetrospective StudiesSurvival AnalysisTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionHospital dischargeFunctional impairmentElderly patientsMyocardial infarctionAcute myocardial infarction survivorsBeta-blocker prescriptionBeta-blocker prophylaxisBeta-blocker treatmentRetrospective cohort studySimilar survival benefitMain outcome measuresMyocardial infarction survivorsAcute care hospitalsEligible patientsCohort studySurvival benefitCare hospitalFunctional statusNational cohortInfarction survivorsOutcome measuresElderly survivorsPatientsCognitive impairment
2003
Outcomes in heart failure patients with preserved ejection fraction Mortality, readmission, and functional decline
Smith GL, Masoudi FA, Vaccarino V, Radford MJ, Krumholz HM. Outcomes in heart failure patients with preserved ejection fraction Mortality, readmission, and functional decline. Journal Of The American College Of Cardiology 2003, 41: 1510-1518. PMID: 12742291, DOI: 10.1016/s0735-1097(03)00185-2.Peer-Reviewed Original ResearchConceptsDepressed ejection fractionRisk of readmissionEjection fractionHeart failureFunctional declineHeart failure patientsHF patientsFailure patientsHospital dischargeHospital readmissionIndependent predictorsClinical outcomesPoor prognosisFunctional statusClinical covariatesClinical trajectoriesReadmissionLower riskPatientsConsiderable burdenCombined outcomeNatural historyMortalityDeathOutcomes
2002
Differences between African Americans and whites in the outcome of heart failure: Evidence for a greater functional decline in African Americans
Vaccarino V, Gahbauer E, Kasl SV, Charpentier PA, Acampora D, Krumholz HM. Differences between African Americans and whites in the outcome of heart failure: Evidence for a greater functional decline in African Americans. American Heart Journal 2002, 143: 1058-1067. PMID: 12075264, DOI: 10.1067/mhj.2002.122123.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAnalysis of VarianceBlack PeopleCohort StudiesFemaleHealth Services AccessibilityHeart FailureHospitalizationHumansIncomeMaleMiddle AgedOutcome Assessment, Health CareProportional Hazards ModelsProspective StudiesQuality of Health CareSocioeconomic FactorsWhite PeopleConceptsGreater functional declineHeart failureCare indicatorsFunctional declineAfrican AmericansSelf-reported health statusSigns of decompensationDecompensated heart failureHistory of hypertensionProspective cohort studyVentricular ejection fractionDaily living functionAfrican American patientsDaily living functioningRenal insufficiencyBaseline characteristicsCohort studyConsecutive patientsEjection fractionHospital admissionFunctional statusAmerican patientsPoor courseLiving functioningHigh risk
2000
Care and outcomes of elderly patients with acute myocardial infarction by physician specialty: the effects of comorbidity and functional limitations
Chen J, Radford M, Wang Y, Krumholz H. Care and outcomes of elderly patients with acute myocardial infarction by physician specialty: the effects of comorbidity and functional limitations. The American Journal Of Medicine 2000, 108: 460-469. PMID: 10781778, DOI: 10.1016/s0002-9343(00)00331-4.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCardiologyComorbidityFamily PracticeFemaleGeriatric AssessmentHospital MortalityHospitalizationHumansInternal MedicineMaleMedicareMyocardial InfarctionPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionMyocardial infarctionGeneral practitionersPhysician specialtyFunctional limitationsComorbid illnessesPatient characteristicsSurvival benefitComorbid conditionsCardiology careNational Cooperative Cardiovascular ProjectEffect of comorbidityCooperative Cardiovascular ProjectBoard-certified cardiologistsInternal medicine subspecialistsMost comorbiditiesClinical characteristicsElderly patientsClinical presentationSpecialty careHospital characteristicsExcess mortalityBaseline differencesMedicine subspecialistsGeneral internists
1998
Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991
Mendes de Leon CF, Krumholz HM, Seeman TS, Vaccarino V, Williams CS, Kasl SV, Berkman LF. Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991. JAMA Internal Medicine 1998, 158: 2341-2348. PMID: 9827785, DOI: 10.1001/archinte.158.21.2341.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedCause of DeathCohort StudiesConnecticutCoronary DiseaseDeath CertificatesDepressionFemaleForecastingHospitalizationHumansIncidenceInterviews as TopicMaleMedical AuditMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionReproducibility of ResultsRisk FactorsSex FactorsSurvival RateConceptsCoronary heart diseaseCHD risk factorsDepressive symptomsRisk factorsCHD outcomesHeart diseaseAge-adjusted relative riskImpaired physical functionIncident coronary diseasePhysical function impairmentIncident CHD eventsNonfatal myocardial infarctionIndependent risk factorMedical chart reviewHealthy older womenCause of deathCHD deathCHD eventsCHD mortalityChart reviewCHD incidenceCoronary diseaseFunction impairmentPhysical functionElderly menA Population-Based Perspective of Changes in Health-Related Quality of Life After Myocardial Infarction in Older Men and Women
de Leon C, Krumholz H, Vaccarino V, Williams C, Glass T, Berkman L, Kas S. A Population-Based Perspective of Changes in Health-Related Quality of Life After Myocardial Infarction in Older Men and Women. Journal Of Clinical Epidemiology 1998, 51: 609-616. PMID: 9674668, DOI: 10.1016/s0895-4356(98)00037-7.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI patientsSelf-rated healthSocial functioningEffects of MICHD risk factorsWomen 65 yearsBurden of illnessHealth-related qualityRecent myocardial infarctionPopulation-based perspectiveQuality of lifePooled logistic regression modelLogistic regression modelsLife-related outcomesRisk factorsPhysical functioningMI periodDepressive symptomsOlder livingOlder menPatientsBivariate analysisLife outcomesSubstantial proportion
1997
Functional Disability Before Myocardial Infarction in the Elderly as a Determinant of Infarction Severity and Postinfarction Mortality
Vaccarino V, Berkman LF, Mendes de Leon CF, Seeman TE, Horwitz RI, Krumholz HM. Functional Disability Before Myocardial Infarction in the Elderly as a Determinant of Infarction Severity and Postinfarction Mortality. JAMA Internal Medicine 1997, 157: 2196-2204. PMID: 9342996, DOI: 10.1001/archinte.1997.00440400046006.Peer-Reviewed Original ResearchConceptsMyocardial infarctionClinical severityFunctional disabilityElderly patientsDaily livingHigh mortalityAcute myocardial infarctionHigher clinical severityMore comorbiditiesPostinfarction mortalityHospital arrivalMI severityInfarction severityHospital treatmentHigh comorbidityRelative riskOutcome measuresCommon conditionPatientsTreatment interventionsMortalityOlder ageSeverity characteristicsSeverityConfidence intervals
1996
Changes in health after elective percutaneous coronary revascularization. A comparison of generic and specific measures.
Krumholz HM, McHorney CA, Clark L, Levesque M, Baim DS, Goldman L. Changes in health after elective percutaneous coronary revascularization. A comparison of generic and specific measures. Medical Care 1996, 34: 754-9. PMID: 8709657, DOI: 10.1097/00005650-199608000-00003.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAngioplasty, Balloon, CoronaryBostonElective Surgical ProceduresFemaleHealth StatusHealth SurveysHumansMaleMental HealthMiddle AgedOutcome Assessment, Health CareProspective StudiesQuality of LifeReproducibility of ResultsSick RoleSurveys and QuestionnairesTime FactorsConceptsElective percutaneous coronary revascularizationCanadian Cardiovascular Society classificationPercutaneous coronary revascularizationHealth-related qualityCoronary revascularizationSpecific Activity ScaleRole limitationsElective percutaneous transluminal coronary angioplastyPercutaneous transluminal coronary angioplastyForm Health SurveyMedical Outcomes StudyTransluminal coronary angioplastyGeneral health perceptionRole physical scaleSF-36 Role Physical scaleSF-36 physical functioning scaleSF-36 measuresPhysical functioning scaleGeneral mental healthPhysical health problemsEmotional health problemsSymptomatic patientsCoronary angioplastyPhysical functioningSociety classification