2023
Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020
Caraballo C, Massey D, Ndumele C, Haywood T, Kaleem S, King T, Liu Y, Lu Y, Nunez-Smith M, Taylor H, Watson K, Herrin J, Yancy C, Faust J, Krumholz H. Excess Mortality and Years of Potential Life Lost Among the Black Population in the US, 1999-2020. JAMA 2023, 329: 1662-1670. PMID: 37191702, PMCID: PMC10189563, DOI: 10.1001/jama.2023.7022.Peer-Reviewed Original ResearchConceptsExcess mortality ratesExcess deathsMortality ratePotential lifeWhite populationExcess mortalitySerial cross-sectional studyHighest excess mortality ratesBlack populationCause-specific mortalityCross-sectional studyHigh mortality rateNon-Hispanic whitesYears of lifeUS national dataMiddle-aged adultsCause mortalityHeart diseaseDeath certificatesNon-Hispanic black populationMAIN OUTCOMEAge groupsDisease controlMortalityBlack males
2016
Association of Guideline-Based Admission Treatments and Life Expectancy After Myocardial Infarction in Elderly Medicare Beneficiaries
Bucholz EM, Butala NM, Normand SL, Wang Y, Krumholz HM. Association of Guideline-Based Admission Treatments and Life Expectancy After Myocardial Infarction in Elderly Medicare Beneficiaries. Journal Of The American College Of Cardiology 2016, 67: 2378-2391. PMID: 27199062, PMCID: PMC5097252, DOI: 10.1016/j.jacc.2016.03.507.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAspirinFemaleFollow-Up StudiesGuideline AdherenceHospitalizationHumansLife ExpectancyMaleMedicareMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPractice Guidelines as TopicThrombolytic TherapyTime-to-TreatmentUnited StatesConceptsAcute myocardial infarctionPrimary percutaneous coronary interventionGuideline-based therapyYears of lifeAdmission therapyLife expectancyMyocardial infarctionMedicare beneficiariesCox proportional hazards regressionAcute reperfusion therapyLate survival benefitReceipt of aspirinPercutaneous coronary interventionLong-term outcomesProportional hazards regressionCooperative Cardiovascular ProjectElderly Medicare beneficiariesDose-response relationshipAssociation of GuidelineShort life expectancyLonger life expectancyReperfusion therapyCoronary interventionD2B timeElderly patients
2015
Smoking status and life expectancy after acute myocardial infarction in the elderly
Bucholz EM, Beckman AL, Kiefe CI, Krumholz HM. Smoking status and life expectancy after acute myocardial infarction in the elderly. Heart 2015, 102: 133. PMID: 26596792, PMCID: PMC5459390, DOI: 10.1136/heartjnl-2015-308263.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCurrent smokersYears of lifeLife expectancyMyocardial infarctionLower short-term mortalityHigher long-term mortalityLower crude mortalityLong-term mortalityBurden of smokingShort-term mortalityCooperative Cardiovascular ProjectElderly Medicare patientsAge-specific associationsMedical record studyCurrent smokingCrude mortalityPatient characteristicsSmoking statusCessation effortsMedicare patientsLong-term effectsSmokingSmokersLower life expectancy
1993
Cost-effectiveness of a smoking cessation program after myocardial infarction
Krumholz H, Cohen B, Tsevat J, Pasternak R, Weinstein M. Cost-effectiveness of a smoking cessation program after myocardial infarction. Journal Of The American College Of Cardiology 1993, 22: 1697-1702. PMID: 8227841, DOI: 10.1016/0735-1097(93)90598-u.Peer-Reviewed Original ResearchConceptsSmoking cessation programAcute myocardial infarctionNurse-managed smoking cessation programCessation programsMyocardial infarctionYears of lifeBeta-adrenergic antagonist therapyLife expectancyOne-way sensitivity analysesTwo-way sensitivity analysesCost-effective interventionHealth care resourcesAntagonist therapySmoking ratesInfarctionCare resourcesSmokersInterventionProgram costsYearsExpectancyTherapyLife
1992
Cost Effectiveness of Thrombolytic Therapy with Streptokinase in Elderly Patients with Suspected Acute Myocardial Infarction
Krumholz H, Pasternak R, Weinstein M, Friesinger G, Ridker P, Tosteson A, Goldman L. Cost Effectiveness of Thrombolytic Therapy with Streptokinase in Elderly Patients with Suspected Acute Myocardial Infarction. New England Journal Of Medicine 1992, 327: 7-13. PMID: 1598117, DOI: 10.1056/nejm199207023270102.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionThrombolytic therapyRisk of deathMyocardial infarctionElderly patientsPatients 75 yearsST-segment elevationOnset of symptomsUse of streptokinaseOne-way sensitivity analysesDecision analytic modelYears of lifeCost-effective treatmentRelative reductionHospital deathStreptokinase therapyOlder patientsClinical circumstancesThrombolytic agentsInfarctionPatientsCost effectivenessTherapyLack of consensusStreptokinase