2023
Association of neighbourhood‐level material deprivation with adverse outcomes and processes of care among patients with heart failure in a single‐payer healthcare system: A population‐based cohort study
Bobrowski D, Dorovenis A, Abdel‐Qadir H, McNaughton C, Alonzo R, Fang J, Austin P, Udell J, Jackevicius C, Alter D, Atzema C, Bhatia R, Booth G, Ha A, Johnston S, Dhalla I, Kapral M, Krumholz H, Roifman I, Wijeysundera H, Ko D, Tu K, Ross H, Schull M, Lee D. Association of neighbourhood‐level material deprivation with adverse outcomes and processes of care among patients with heart failure in a single‐payer healthcare system: A population‐based cohort study. European Journal Of Heart Failure 2023, 25: 2274-2286. PMID: 37953731, DOI: 10.1002/ejhf.3090.Peer-Reviewed Original ResearchProcess of careCardiovascular hospitalizationHeart failureIncident heart failure patientsNeighbourhood-level material deprivationPopulation-based cohort studyAge groupsPopulation-based retrospective studyCause-specific hazards regressionCause-specific hospitalizationsHeart failure patientsAdvanced cardiac imagingNeighborhood material deprivationHealthcare systemSingle-payer healthcare systemMultiple covariate adjustmentOlder age groupsHigher hazardUniversal healthcare systemCardiology visitsDeprived neighbourhoodsCause deathCause mortalityCohort studyFailure patientsASSOCIATION OF NEIGHBORHOOD-LEVEL MATERIAL DEPRIVATION WITH ADVERSE OUTCOMES AND PROCESSES OF CARE AMONG PATIENTS WITH HEART FAILURE IN A SINGLE-PAYER HEALTHCARE SYSTEM: A POPULATION-BASED COHORT STUDY
Dorovenis A, Bobrowski D, Abdel-Qadir H, McNaughton C, Alonzo R, Fang J, Austin P, Udell J, Jackevicius C, Alter D, Bhatia R, Atzema C, Ha A, Johnston S, Dhalla I, Kapral M, Krumholz H, Wijeysundera H, Ko D, Tu K, Ross H, Schull M, Lee D. ASSOCIATION OF NEIGHBORHOOD-LEVEL MATERIAL DEPRIVATION WITH ADVERSE OUTCOMES AND PROCESSES OF CARE AMONG PATIENTS WITH HEART FAILURE IN A SINGLE-PAYER HEALTHCARE SYSTEM: A POPULATION-BASED COHORT STUDY. Journal Of The American College Of Cardiology 2023, 81: 361. DOI: 10.1016/s0735-1097(23)00805-7.Peer-Reviewed Original Research
2021
Association of neighbourhood-level poverty with outcomes and clinical care following atrial fibrillation diagnosis in a universal healthcare system
Akioyamen L, Abdel-Qadir H, Pang A, Ha A, Jackevicius C, Alter D, Bhatia R, Dhalla I, Krumholz H, Roifman I, Wijeysundera H, Atzema C, Ko D, Schull M, Lee D, Investigators T. Association of neighbourhood-level poverty with outcomes and clinical care following atrial fibrillation diagnosis in a universal healthcare system. European Heart Journal 2021, 42: ehab724.0447. DOI: 10.1093/eurheartj/ehab724.0447.Peer-Reviewed Original ResearchAF diagnosisAtrial fibrillation diagnosisUniversal healthcare systemCardiology visitsIschemic strokeDeprivation quintileMedication coverageVascular diseaseCause-specific hazard regression modelStroke/transient ischemic attackPopulation-based cohort studyNeighborhood-level povertyAnti-arrhythmic medicationsHighest deprivation quintileRhythm control interventionsWorse baseline healthHeart failure hospitalizationTransient ischemic attackUniversal healthcareHazards regression modelsHealthcare systemProcess of careCommunity-dwelling adultsEquitable health careLong-term care
2020
Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015
Zhong Q, Gao Y, Zheng X, Chen J, Masoudi FA, Lu Y, Feng Y, Hu S, Zhang Q, Huang C, Wang Y, Krumholz HM, Li X, Zhou Y. Geographic Variation in Process and Outcomes of Care for Patients With Acute Myocardial Infarction in China From 2001 to 2015. JAMA Network Open 2020, 3: e2021182. PMID: 33095248, PMCID: PMC7584924, DOI: 10.1001/jamanetworkopen.2020.21182.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionProcess of careHospital mortalityMyocardial infarctionOdds ratioAngiotensin receptor blockersCross-sectional studyOutcomes of careReceptor blockersReperfusion therapyPatient characteristicsTherapy useCare measuresPatient hospitalizationIdeal patientOutcome measuresMAIN OUTCOMEΒ-blockersAMI managementPatientsEnzyme inhibitorsSignificant geographic variationMortalityCareHospitalization
2018
Emergency Department Volume and Outcomes for Patients After Chest Pain Assessment
Ko DT, Dattani ND, Austin PC, Schull MJ, Ross JS, Wijeysundera HC, Tu JV, Eberg M, Koh M, Krumholz HM. Emergency Department Volume and Outcomes for Patients After Chest Pain Assessment. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004683. PMID: 30354285, DOI: 10.1161/circoutcomes.118.004683.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeChest painHigh-volume EDsCoronary syndromeED volumeVolume thresholdCardiac medication useChest pain assessmentLower adverse outcomesEmergency department visitsAdjusted odds ratioPopulation-based dataProcess of carePotential confounding variablesHigher ED volumesHierarchical logistic regression modelsLogistic regression modelsEmergency department volumeCause deathCardiac testingComposite outcomeDepartment visitsDiabetes mellitusMedication usePrimary outcome
2017
ACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Chan WV, Pearson TA, Bennett GC, Cushman WC, Gaziano TA, Gorman PN, Handler J, Krumholz HM, Kushner RF, MacKenzie TD, Sacco RL, Smith SC, Stevens VJ, Wells BL. ACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Journal Of The American College Of Cardiology 2017, 69: 1076-1092. PMID: 28132746, DOI: 10.1016/j.jacc.2016.11.004.Peer-Reviewed Original ResearchConceptsEducational outreach visitsClinical practice guidelinesProcess of careClinical outcomesOutreach visitsPractice guidelinesSystematic reviewImplementation interventionsCardiology/American Heart Association Task ForceAmerican Heart Association Task ForceLow baseline adherenceOverweight/obesityGuideline implementation strategiesMixed effectivenessGuideline implementation interventionsCost-effectiveness outcomesProvider incentivesEvidence-based strategiesBlood pressureBlood InstituteImplementation science literatureNational HeartClinicians' knowledgeAmerican CollegeExclusion criteriaACC/AHA Special Report
Chan WV, Pearson TA, Bennett GC, Cushman WC, Gaziano TA, Gorman PN, Handler J, Krumholz HM, Kushner RF, MacKenzie TD, Sacco RL, Smith SC, Stevens VJ, Wells BL, Castillo G, Heil SK, Stephens J, Jacobson Vann J. ACC/AHA Special Report. Circulation 2017, 135: e122-e137. PMID: 28126839, DOI: 10.1161/cir.0000000000000481.Peer-Reviewed Original ResearchConceptsEducational outreach visitsClinical practice guidelinesProcess of careClinical outcomesOutreach visitsPractice guidelinesImplementation interventionsSystematic reviewLow baseline adherenceOverweight/obesityMixed effectivenessGuideline implementation interventionsCost-effectiveness outcomesProvider incentivesEvidence-based strategiesBlood pressureBlood InstituteImplementation science literatureNational HeartClinicians' knowledgeExclusion criteriaIndependent reviewersCare outcomesClinician skepticismHigher age
2006
Regional Differences in Process of Care and Outcomes for Older Acute Myocardial Infarction Patients in the United States and Ontario, Canada
Ko DT, Krumholz HM, Wang Y, Foody JM, Masoudi FA, Havranek EP, You JJ, Alter DA, Stukel TA, Newman AM, Tu JV. Regional Differences in Process of Care and Outcomes for Older Acute Myocardial Infarction Patients in the United States and Ontario, Canada. Circulation 2006, 115: 196-203. PMID: 17190861, DOI: 10.1161/circulationaha.106.657601.Peer-Reviewed Original ResearchConceptsRisk-standardized mortality ratesTreatment patternsAMI patientsMortality rateOlder acute myocardial infarction patientsInvasive cardiac procedure useAcute myocardial infarction treatmentAcute myocardial infarction patientsBeta-blocker useCardiac catheterization useCardiac procedure useEnzyme inhibitor useMyocardial infarction patientsProcess of careService Medicare beneficiariesHealth care delivery systemSimilar treatment patternsMyocardial infarction treatmentCare delivery systemInvasive cardiac therapyBaseline characteristicsInhibitor useMedication useIllness severityRandomized trials
2005
Quality of Care and Outcomes of Older Patients With Heart Failure Hospitalized in the United States and Canada
Ko DT, Tu JV, Masoudi FA, Wang Y, Havranek EP, Rathore SS, Newman AM, Donovan LR, Lee DS, Foody JM, Krumholz HM. Quality of Care and Outcomes of Older Patients With Heart Failure Hospitalized in the United States and Canada. JAMA Internal Medicine 2005, 165: 2486-2492. PMID: 16314545, DOI: 10.1001/archinte.165.21.2486.Peer-Reviewed Original ResearchConceptsHeart failureProcess of careRisk-standardized mortalityQuality of careUS patientsMortality rateEnzyme inhibitorsLower crude mortality rateLower short-term mortalityAngiotensin-converting enzyme inhibitorRisk-standardized mortality ratesVentricular ejection fraction assessmentOutcomes of patientsShort-term mortalityUS Medicare beneficiariesIndividuals 65 yearsCrude mortality rateEjection fraction assessmentLow-risk characteristicsHealth care expendituresOlder patientsCanadian patientsCommon causeMedicare beneficiariesPatients
2002
Evaluation of a Consumer-Oriented Internet Health Care Report Card: The Risk of Quality Ratings Based on Mortality Data
Krumholz HM, Rathore SS, Chen J, Wang Y, Radford MJ. Evaluation of a Consumer-Oriented Internet Health Care Report Card: The Risk of Quality Ratings Based on Mortality Data. JAMA 2002, 287: 1277-1287. PMID: 11886319, DOI: 10.1001/jama.287.10.1277.Peer-Reviewed Original ResearchConceptsProcess of careMortality rateHospital ratingEnzyme inhibitorsUS acute care hospitalsSystematic medical record reviewIndividual hospitalsStudy periodAcute myocardial infarction mortalityAcute reperfusion therapyReperfusion therapy ratesMedical record reviewService beneficiaries 65 yearsCooperative Cardiovascular ProjectBeneficiaries 65 yearsAcute care hospitalsMyocardial infarction mortalityHealth care report cardsQuality of careCare report cardsHospital performanceReperfusion therapyTherapy ratesCare hospitalRecord review
2001
The case for comprehensive quality indicator reliability assessment
Scinto J, Galusha D, Krumholz H, Meehan T. The case for comprehensive quality indicator reliability assessment. Journal Of Clinical Epidemiology 2001, 54: 1103-1111. PMID: 11675161, DOI: 10.1016/s0895-4356(01)00381-x.Peer-Reviewed Original ResearchConceptsComposite quality indicatorHospital medical recordsProcess of careRecent dischargeKappa valuesPrevalence effectBias-adjusted kappaHospital arrivalAntibiotic administrationMedical recordsOverall eligibilityOxygenation assessmentQuality indicatorsCareKappa statisticsInterrater agreementKappaEligibility
2000
What's Happening in Quality Improvement at the Local Hospital: A State Wide Study From the Cooperative Cardiovascular Project
Holmboe E, Meehan T, Radford M, Wang Y, Krumholz H. What's Happening in Quality Improvement at the Local Hospital: A State Wide Study From the Cooperative Cardiovascular Project. American Journal Of Medical Quality 2000, 15: 106-113. PMID: 10872260, DOI: 10.1177/106286060001500304.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCooperative Cardiovascular ProjectFull-time equivalentsAMI careNonfederal hospitalsIndividual hospitalsCare of patientsProcess of careMultidisciplinary QI teamQuality of careQuality improvement activitiesMyocardial infarctionLocal hospitalImprovement interventionsHospitalRegistered NursesSecondary analysisPhysician championsQI teamsCareScientific evidenceState-wide studyCritical pathwaysQuestionnaire studyDepartment
1999
Use of critical pathways to improve the care of patients with acute myocardial infarction11Dr. Krumholz is a Paul Beeson Faculty Scholar. This article was written by CDR Eric S. Holmboe while a fellow in the Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine. The views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government.
Holmboe E, Meehan T, Radford M, Wang Y, Marciniak T, Krumholz H. Use of critical pathways to improve the care of patients with acute myocardial infarction11Dr. Krumholz is a Paul Beeson Faculty Scholar. This article was written by CDR Eric S. Holmboe while a fellow in the Robert Wood Johnson Clinical Scholars Program, Yale University School of Medicine. The views expressed in this article are those of the author and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. The American Journal Of Medicine 1999, 107: 324-331. PMID: 10527033, DOI: 10.1016/s0002-9343(99)00239-9.Peer-Reviewed Original ResearchConceptsLength of stayEvidence-based medical therapyProportion of patientsMyocardial infarctionMedical therapyMedicare patientsMain endpointCritical pathwaysAngiotensin-converting enzyme inhibitorAcute myocardial infarctionCare of patientsLongitudinal cohort studyProcess of careFirst dayQuality of careCross-sectional analysisReperfusion therapyCohort studyPrincipal diagnosisConnecticut hospitalsPatientsEnzyme inhibitorsYale University SchoolStayClinical Scholars Program
1998
Sex Differences in Mortality After Myocardial Infarction: Evidence for a Sex-Age Interaction
Vaccarino V, Horwitz RI, Meehan TP, Petrillo MK, Radford MJ, Krumholz HM. Sex Differences in Mortality After Myocardial Infarction: Evidence for a Sex-Age Interaction. JAMA Internal Medicine 1998, 158: 2054-2062. PMID: 9778206, DOI: 10.1001/archinte.158.18.2054.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMortality rateAge groupsSex-age interactionOlder womenHigh mortalityHigher hospital mortality rateSex differencesAge group 75 yearsHospital mortality rateRetrospective cohort studyProcess of careYounger age groupsSame age groupHospital deathOlder patientsCohort studyConsecutive patientsPatient ageComorbid conditionsHospital characteristicsClinical severityMedical recordsConnecticut hospitalsHigher odds
1997
Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia
Meehan TP, Fine MJ, Krumholz HM, Scinto JD, Galusha DH, Mockalis JT, Weber GF, Petrillo MK, Houck PM, Fine JM. Quality of Care, Process, and Outcomes in Elderly Patients With Pneumonia. JAMA 1997, 278: 2080-2084. PMID: 9403422, DOI: 10.1001/jama.1997.03550230056037.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Bacterial AgentsBlood Specimen CollectionCenters for Medicare and Medicaid Services, U.S.FemaleHospital MortalityHumansLogistic ModelsMaleMedicareOutcome and Process Assessment, Health CarePneumoniaQuality Indicators, Health CareRetrospective StudiesSeverity of Illness IndexSurvival AnalysisUnited StatesConceptsBlood culture collectionProcess of careHospital arrivalElderly patientsAntibiotic administrationQuality of careBlood culturesMulticenter retrospective cohort studyOxygenation assessmentInitial antibiotic administrationRetrospective cohort studyCare performanceMedical record reviewHours of arrivalAcute care hospitalsLogistic regression analysisCohort studyCare hospitalImproved survivalRecord reviewHospital careMedicare patientsFrequent causePneumoniaPatients