2023
Impact of Sex‐ and Gender‐Related Factors on Length of Stay Following Non–ST‐Segment–Elevation Myocardial Infarction: A Multicountry Analysis
Bender U, Norris C, Dreyer R, Krumholz H, Raparelli V, Pilote L. Impact of Sex‐ and Gender‐Related Factors on Length of Stay Following Non–ST‐Segment–Elevation Myocardial Infarction: A Multicountry Analysis. Journal Of The American Heart Association 2023, 12: e028553. PMID: 37489737, PMCID: PMC10492965, DOI: 10.1161/jaha.122.028553.Peer-Reviewed Original ResearchConceptsSegment elevation myocardial infarctionMyocardial infarctionGender-related factorsLonger LOSSegment elevation myocardial infarction diagnosisConclusions Older ageObservational cohort studyAdverse clinical outcomesAdjusted multivariable modelAcute myocardial infarctionLength of stayImpact of sexHealth care expendituresGENESIS-PRAXYHospital lengthNon–STCause mortalityCohort studyIndependent predictorsMyocardial infarction diagnosisClinical outcomesShorter LOSMedical historyMultivariable modelUnivariate associations
2020
Changes in Functional Status and Health-Related Quality of Life in Older Adults After Surgical, Interventional, or Medical Management of Acute Myocardial Infarction
Mori M, Djulbegovic M, Hajduk A, Holland ML, Krumholz HM, Chaudhry SI. Changes in Functional Status and Health-Related Quality of Life in Older Adults After Surgical, Interventional, or Medical Management of Acute Myocardial Infarction. Seminars In Thoracic And Cardiovascular Surgery 2020, 33: 72-81. PMID: 32439546, PMCID: PMC7983308, DOI: 10.1053/j.semtcvs.2020.05.001.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graftPercutaneous coronary interventionAcute myocardial infarctionPhysical component scaleMedical managementFunctional statusOlder patientsMyocardial infarctionArtery bypass graftHealth-related qualityAge 75 yearsPatient-centered outcomesRisk of declinePredictors of declineQuality of lifeUnadjusted incidenceCoronary interventionADL declineCardiac surgeryMedical therapyBypass graftSF-12Multivariable modelHRQoLPatients
2014
Age-specific gender differences in early mortality following ST-segment elevation myocardial infarction in China
Zheng X, Dreyer RP, Hu S, Spatz ES, Masoudi FA, Spertus JA, Nasir K, Li X, Li J, Wang S, Krumholz HM, Jiang L. Age-specific gender differences in early mortality following ST-segment elevation myocardial infarction in China. Heart 2014, 101: 349. PMID: 25510395, PMCID: PMC4453015, DOI: 10.1136/heartjnl-2014-306456.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overChinaDrug UtilizationFemaleHospital MortalityHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionMyocardial RevascularizationPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesRural PopulationSex FactorsUrban PopulationConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionGender-age interactionHospital mortalityEarly mortalityMyocardial infarctionChina PEACE-Retrospective AMI StudyHospital mortality rateYears of ageAge-specific gender differencesPatient characteristicsHospital characteristicsMultivariable modelMortality rateGender differencesChinese populationMortalityYounger groupChinese hospitalsWomenAMI studyMenInfarctionAgeRepresentative sample
2013
Quality collaboratives and campaigns to reduce readmissions: What strategies are hospitals using?
Bradley EH, Sipsma H, Curry L, Mehrotra D, Horwitz LI, Krumholz H. Quality collaboratives and campaigns to reduce readmissions: What strategies are hospitals using? Journal Of Hospital Medicine 2013, 8: 601-608. PMID: 24038927, PMCID: PMC4029612, DOI: 10.1002/jhm.2076.Peer-Reviewed Original ResearchMeSH KeywordsContinuity of Patient CareCooperative BehaviorCross-Sectional StudiesHealth Care SurveysHealth Plan ImplementationHumansInformation DisseminationInternetLogistic ModelsMedication ReconciliationMultivariate AnalysisPatient DischargePatient ReadmissionQuality Assurance, Health CareQuality Indicators, Health CareUnited StatesConceptsQuality collaborativesCardiac rehabilitation servicesMultivariable logistic regressionSkilled nursing facilitiesHospital readmissionMedication reconciliationTreating physicianPatient dischargePatient referralOutpatient physiciansMultivariable modelNursing facilitiesStandard frequency analysisHospitalRehabilitation servicesWeb-based surveyReadmissionLogistic regressionQuality InitiativeHospital strategiesPhysiciansCurrent useCollaborativesPatientsSTAAR
2011
National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment time
2010
Variation in Hospital Mortality Rates for Patients With Acute Myocardial Infarction
Bradley EH, Herrin J, Curry L, Cherlin EJ, Wang Y, Webster TR, Drye EE, Normand SL, Krumholz HM. Variation in Hospital Mortality Rates for Patients With Acute Myocardial Infarction. The American Journal Of Cardiology 2010, 106: 1108-1112. PMID: 20920648, DOI: 10.1016/j.amjcard.2010.06.014.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHospital characteristicsMyocardial infarctionMortality rateCross-sectional national studyHospital mortality rateHospital patient populationAmerican Hospital Association surveyAMI dischargeMean hospitalHospital outcomesCardiac facilitiesPatient populationAMI volumeMultivariable modelPatient profilesMedicare beneficiariesHospitalHospital bedsPatientsTeaching statusUnited States Census dataStates Census dataInfarctionStatus profileBeyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey
Spatz ES, Ross JS, Desai MM, Canavan ME, Krumholz HM. Beyond insurance coverage: Usual source of care in the treatment of hypertension and hypercholesterolemia. Data from the 2003-2006 National Health and Nutrition Examination Survey. American Heart Journal 2010, 160: 115-121. PMID: 20598981, PMCID: PMC3025407, DOI: 10.1016/j.ahj.2010.04.013.Peer-Reviewed Original ResearchConceptsTreatment of hypertensionNutrition Examination SurveyInsurance statusMedication treatmentExamination SurveyNational HealthUsual sourceAdult Treatment Panel III recommendationsJoint National Committee 7Multivariable logistic regression modelingInsurance coverageSeparate multivariable modelsChronic disease managementLogistic regression modelingHigh-quality careRace/ethnicityCardiovascular diseaseMultivariable modelStratified analysisHypertensionHypercholesterolemiaRegular sourceCareDisease managementIndependent effectsGeriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure
Chaudhry SI, Wang Y, Gill TM, Krumholz HM. Geriatric Conditions and Subsequent Mortality in Older Patients With Heart Failure. Journal Of The American College Of Cardiology 2010, 55: 309-316. PMID: 20117435, PMCID: PMC2832791, DOI: 10.1016/j.jacc.2009.07.066.Peer-Reviewed Original ResearchConceptsLong-term mortalityGeriatric conditionsNet reclassification improvementMobility disabilityOlder patientsReclassification improvementRisk factorsMultivariable logistic regression modelHeart failure hospitalizationIndependent risk factorTraditional risk factorsMedical record dataFinal multivariable modelYears of ageLogistic regression modelsFailure hospitalizationTerm mortalityHeart failureIndependent predictorsPrognostic importanceMean ageMultivariable modelMedicare beneficiariesMortality rateSubsequent mortality
2009
Door-to-Balloon Times in Hospitals Within the Get-With-The-Guidelines Registry After Initiation of the Door-to-Balloon (D2B) Alliance
Nallamothu BK, Krumholz HM, Peterson ED, Pan W, Bradley E, Stern AF, Masoudi FA, Janicke DM, Hernandez AF, Cannon CP, Fonarow GC, Investigators D. Door-to-Balloon Times in Hospitals Within the Get-With-The-Guidelines Registry After Initiation of the Door-to-Balloon (D2B) Alliance. The American Journal Of Cardiology 2009, 103: 1051-1055. PMID: 19361588, DOI: 10.1016/j.amjcard.2008.12.030.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary percutaneous coronary interventionD2B AlliancePercentage of patientsGWTG-CADBalloon timeST-elevation myocardial infarctionNational quality improvement effortsQuality improvement effortsBalloon (D2B) AllianceDTB timeNontransferred patientsCoronary interventionPatient characteristicsMyocardial infarctionMultivariable modelAmerican CollegePatientsDisease programsHospitalStudy periodSignificant differencesHospital performanceMinutesImprovement efforts
2007
Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction
Garavalia LS, Decker C, Reid KJ, Lichtman JH, Parashar S, Vaccarino V, Krumholz HM, Spertus JA. Does Health Status Differ between Men And Women in Early Recovery after Myocardial Infarction. Journal Of Women's Health 2007, 16: 93-101. PMID: 17324100, DOI: 10.1089/jwh.2006.m073.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHealth statusNon-ST segment elevation myocardial infarctionRisk-adjusted multivariable modelsSegment elevation myocardial infarctionChronic lung diseaseElevation myocardial infarctionWorse health statusPoor physical functioningQuality of lifeResidual anginaCoronary revascularizationHeart failureLung diseaseMI patientsPhysical functionMultivariable PoissonMultivariable modelPhysical functioningEarly recoveryGreater prevalenceInfarctionPatientsAdditional treatmentWomen
2006
Trends in Acute Myocardial Infarction in 4 US States Between 1992 and 2001
Masoudi FA, Foody JM, Havranek EP, Wang Y, Radford MJ, Allman RM, Gold J, Wiblin RT, Krumholz HM. Trends in Acute Myocardial Infarction in 4 US States Between 1992 and 2001. Circulation 2006, 114: 2806-2814. PMID: 17145994, DOI: 10.1161/circulationaha.106.611707.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAngiotensin-converting enzyme inhibitorEnzyme inhibitorsPrimary discharge diagnosisHealth system perspectiveQuality of careMore comorbiditiesClinical characteristicsDischarge diagnosisMyocardial infarctionAMI careMedicare patientsMultivariable modelTreatment criteriaMedicare populationTreatment ratesAspirinHealth impactsMortalityCarePresent studyOutcomesIndicator definitionsDiverse populationsInhibitorsHydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction
Foody JM, Rathore SS, Galusha D, Masoudi FA, Havranek EP, Radford MJ, Krumholz HM. Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction. Journal Of The American Geriatrics Society 2006, 54: 421-430. PMID: 16551308, PMCID: PMC2797316, DOI: 10.1111/j.1532-5415.2005.00635.x.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overAtorvastatinCholesterol, LDLDrug PrescriptionsFatty Acids, MonounsaturatedFemaleFluvastatinFollow-Up StudiesHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesLovastatinMaleMyocardial InfarctionOdds RatioPravastatinPyridinesPyrrolesRetrospective StudiesSurvival RateTreatment OutcomeConceptsAcute myocardial infarctionHydroxymethylglutaryl-CoA reductase inhibitorsStatin therapyMyocardial infarctionLower mortalityOlder personsReductase inhibitorsPrincipal discharge diagnosisAcute care hospitalsCause mortalityEligible patientsOlder patientsYounger patientsCare hospitalDischarge prescriptionsPrimary outcomeDischarge diagnosisHospital characteristicsEfficacy dataMedicare patientsMultivariable modelObservational studyPatientsStatinsDischarge statins
2005
The Complexity and Cost of Drug Regimens of Older Patients Hospitalized With Heart Failure in the United States, 1998-2001
Masoudi FA, Baillie CA, Wang Y, Bradford WD, Steiner JF, Havranek EP, Foody JM, Krumholz HM. The Complexity and Cost of Drug Regimens of Older Patients Hospitalized With Heart Failure in the United States, 1998-2001. JAMA Internal Medicine 2005, 165: 2069-2076. PMID: 16216996, DOI: 10.1001/archinte.165.18.2069.Peer-Reviewed Original ResearchConceptsHeart failureOlder patientsNumber of drugsDrug regimensComplex drug regimensPatients 65 yearsChronic lung diseaseNumber of dosesPrior revascularizationConcurrent prescriptionsMultiple comorbiditiesChronic medicationsElderly patientsHospital dischargeMultiple medicationsMedical therapyLung diseaseMultivariable modelDrug treatmentWhite raceMore drugsPatientsYounger ageDrugsUtilization measuresThiazolidinediones, Metformin, and Outcomes in Older Patients With Diabetes and Heart Failure
Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, Metformin, and Outcomes in Older Patients With Diabetes and Heart Failure. Circulation 2005, 111: 583-590. PMID: 15699279, DOI: 10.1161/01.cir.0000154542.13412.b1.Peer-Reviewed Original ResearchConceptsHeart failureInsulin-sensitizing drugsOlder patientsLower riskCox proportional hazards modelAntidiabetic drug prescriptionRetrospective cohort studyPrincipal discharge diagnosisClustering of patientsProportional hazards modelCohort studySecondary outcomesPrimary outcomeMetformin treatmentRandomized trialsThiazolidinedione treatmentDischarge diagnosisInsulin sensitizersAdverse outcomesDrug prescriptionsMultivariable modelObservational studyHospital variablesThiazolidinedione classHigh risk
2004
Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction
Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA. Prognostic Value of Health Status in Patients With Heart Failure After Acute Myocardial Infarction. Circulation 2004, 110: 546-551. PMID: 15262843, DOI: 10.1161/01.cir.0000136991.85540.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmericasCardiovascular DiseasesCohort StudiesComorbidityDisease-Free SurvivalEplerenoneEuropeFemaleHealth Status IndicatorsHeart FailureHospitalizationHumansMaleMiddle AgedMineralocorticoid Receptor AntagonistsMyocardial InfarctionPrognosisProspective StudiesRisk FactorsSeverity of Illness IndexSpironolactoneConceptsKansas City Cardiomyopathy QuestionnaireAcute myocardial infarctionHeart failureKCCQ-OSMyocardial infarctionHealth statusKCCQ scoresCardiovascular mortalityPrognostic valueDisease-specific health status instrumentRecent acute myocardial infarctionSubsequent cardiovascular eventsEvent-free survivalOutpatient clinical practiceFirst outpatient visitHealth status instrumentsPatients' health statusQuality of lifeCardiovascular eventsClinical characteristicsOutpatient visitsMultivariable modelInternational cohortFunctional limitationsClinical practice
2003
Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure
Rumsfeld JS, Havranek E, Masoudi FA, Peterson ED, Jones P, Tooley JF, Krumholz HM, Spertus JA, Consortium C. Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. Journal Of The American College Of Cardiology 2003, 42: 1811-1817. PMID: 14642693, DOI: 10.1016/j.jacc.2003.07.013.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireKCCQ summary scoreDepressive symptomsQuality of lifeHealth statusKCCQ scoresHeart failureDepressed patientsSummary scoresMulticenter prospective cohort studyStrongest predictorBaseline KCCQ scoresProspective cohort studySignificant depressive symptomsSpecific health statusTreatment of depressionShort-term worseningPredictors of changeHF careHF symptomsCohort studyPrimary outcomePotential confoundersPatient variablesMultivariable model