2016
Association of Admission to Veterans Affairs Hospitals vs Non–Veterans Affairs Hospitals With Mortality and Readmission Rates Among Older Men Hospitalized With Acute Myocardial Infarction, Heart Failure, or Pneumonia
Nuti SV, Qin L, Rumsfeld JS, Ross JS, Masoudi FA, Normand SL, Murugiah K, Bernheim SM, Suter LG, Krumholz HM. Association of Admission to Veterans Affairs Hospitals vs Non–Veterans Affairs Hospitals With Mortality and Readmission Rates Among Older Men Hospitalized With Acute Myocardial Infarction, Heart Failure, or Pneumonia. JAMA 2016, 315: 582-592. PMID: 26864412, PMCID: PMC5459395, DOI: 10.1001/jama.2016.0278.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNon-VA hospitalsReadmission ratesHeart failureVA hospitalsMortality rateVeterans AffairsMyocardial infarctionOlder menMedicare Standard Analytic FilesRisk-standardized mortality ratesCause readmission rateCause mortality ratesHigher readmission ratesStandard Analytic FilesVeterans Affairs hospitalRisk-standardized readmission ratesAdministrative claims dataAcute care hospitalsAssociation of admissionLittle contemporary informationLower mortality rateCross-sectional analysisAnalysis cohortCare hospital
2015
Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest
Chan PS, Krumholz HM, Spertus JA, Curtis LH, Li Y, Hammill BG, Nallamothu BK, investigators A. Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest. American Heart Journal 2015, 169: 870-878.e1. PMID: 26027626, PMCID: PMC4451609, DOI: 10.1016/j.ahj.2015.02.016.Peer-Reviewed Original ResearchConceptsInhospital cardiac arrestLong-term mortalityHospital cardiac arrestCardiac arrestICD treatmentLower long-term mortalityImplantable cardioverter-defibrillator therapyHigh illness acuityHigher unadjusted mortalityICD-treated patientsCardiac Arrest RegistryCardioverter-defibrillator therapyPulseless ventricular tachycardiaHigh-risk populationComparative effectiveness studiesLong-term survivalPropensity score analysisLower mortality rateArrest etiologyEligible survivorsICD trialsHospital deathICD therapyIndex hospitalizationUntreated patients
2005
Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Foody JM, Wang Y, Herrin J, Masoudi FA, Havranek EP, Ordin DL, Krumholz HM. Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2005, 149: 121-128. PMID: 15660043, PMCID: PMC2790278, DOI: 10.1016/j.ahj.2004.06.008.Peer-Reviewed Original ResearchConceptsAngiotensin receptor blockersNational Heart Failure ProjectLeft ventricular systolic functionQuality of careACE inhibitor prescriptionHeart Failure ProjectService Medicare patientsHeart failureInhibitor prescriptionMedicare patientsMultivariable hierarchical logistic regression modelsLower crude ratesPrescription of angiotensinLeft ventricular dysfunctionVentricular systolic functionYear of admissionHierarchical logistic regression modelsLower mortality rateLogistic regression modelsSex differencesLow overall rateMultivariable adjustmentVentricular dysfunctionElderly patientsReceptor blockers
2003
Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure. JAMA 2003, 289: 871-878. PMID: 12588271, DOI: 10.1001/jama.289.7.871.Peer-Reviewed Original ResearchConceptsSerum digoxin concentrationHigh serum digoxin concentrationsLeft ventricular ejection fractionVentricular ejection fractionHeart failureMortality rateDIG trialDigoxin therapyEjection fractionDigoxin concentrationsDepressed left ventricular systolic functionDigitalis Investigation Group trialHigher absolute mortality rateLeft ventricular systolic functionOverall mortality benefitVentricular systolic functionCause mortality ratesAbsolute mortality ratesLower mortality rateCause mortalityMultivariable adjustmentMortality benefitSystolic functionClinical outcomesSerum concentrations
2001
Sex differences in 2-year mortality after hospital discharge for myocardial infarction.
Vaccarino V, Krumholz H, Yarzebski J, Gore J, Goldberg R. Sex differences in 2-year mortality after hospital discharge for myocardial infarction. Annals Of Internal Medicine 2001, 134: 173-81. PMID: 11177329, DOI: 10.7326/0003-4819-134-3-200102060-00007.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHigh mortality rateHospital dischargeMortality rateMedical historyHigher long-term mortality ratesCommunity-based prospective cohort studyLong-term mortality ratesGreater riskMortality 2 yearsProspective cohort studyDemographic characteristicsAcute myocardial infarctionYears of ageLower mortality rateSex differencesHospital mortalityClinical characteristicsCohort studyOlder patientsAge womenCommunity hospitalLower riskInfarctionPatients