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ACC Data Analytic Center


The Yale/YNHH CORE Registry Data Analytic Center (RDAC) leverages our scientific expertise and infrastructure to provide comprehensive data analytic services, using an interactive and multidisciplinary approach. Our analysis of registry-based data is employed to generate generalizable research through the conduct and development of risk scores, clinical comparative effectiveness studies, epidemiological and surveillance investigations, quality measurement design and evaluation, and pharmaceutical and medical device industry research. Underscoring our experience and commitment to collaboration, since 2007 the RDAC has presided over the analysis of almost 200 projects with dozens of investigators across the country and around the world. These projects have included the analysis of data collected in both in-hospital and outpatient settings, as well as data generated from medical record abstraction and cloud-based electronic health records.

The Yale/YNHH CORE RDAC team is comprised of talented faculty and staff who are engaged in evaluating and improving quality of care, determining economically attractive strategies, tracking trends in patterns of care, developing and evaluating disease management and decision support tools, characterizing risk, profiling hospital performance, and evaluating the effectiveness of health care strategies, among others.

By partnering with academic, industry, and government organizations, our team works to improve patient outcomes, inform best practices around emerging technologies, guide health care policy and advance science through scholarship.

Current Partnerships

American College of Cardiology - National Cardiovascular Data Registry

The National Cardiovascular Data Registry (NCDR) is the American College of Cardiology's (ACC) suite of registries designed to help hospitals and private practices measure and improve the quality of cardiovascular care they provide. Beginning in 2007, the Yale/YNHH CORE RDAC has served as a data analytic center for 6 of the ACC NCDR registries. The goal of this work is to generate new knowledge and insights into the care of patients with cardiovascular disease through analysis of the robust clinical data submitted to the NCDR registries. A team of CORE researchers works closely with NCDR staff to provide logistical and analytical support for research proposals and targeted projects related to its ICD Registry™, CathPCI Registry®, Chest Pain-MI Registry™, LAAO Registry™, Afib Ablation Registry and PVI Registry™.

The following Information is accurate as of May 2020.

ICD Registry

  • 119 studies
  • 88 manuscripts published (or in press)
  • 100 abstracts presented (or to be presented) at professional meetings

CathPCI Registry

  • 45 studies
  • 27 manuscripts published (or in press)
  • 40 abstracts presented (or to be presented) at professional meetings

Chest Pain-MI Registry™

  • 7 studies
  • 4 manuscripts published articles
  • 5 abstracts presented (or to be presented) at professional meetings

LAAO Registry™

  • 11 studies
  • 1 manuscript published
  • 2 abstracts presented (or to be presented) at professional meetings

AFib Ablation Registry™ (new to RDAC)

  • 1 study
  • 1 abstract (to be presented) at a professional meeting

PVI Registry™ (new to RDAC)

  • 1 study

Recent Strategic Projects and Grants

In addition to the studies above, the RDAC has worked closely with our partnerships on other projects, including the following:

  • NIH/NHLBI grants titled Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF) (1R56HL142765-01 (1 year) and 1R01HL142765-01A1 (4 years) (PI: Freeman, James) (in conjunction with Boston Scientific Corporation)
  • NIH/NHLBI grant titled Translating Outstanding Performance in Percutaneous Coronary Intervention (TOP PCI) (1 U01 HL105270-01).
  • Development and maintenance of multiple risk models
  • Development of measures for NQF endorsement
  • Device post-approval studies
  • Systemic evaluation of public reporting initiatives

For more information about the NCDR and its registries, please visit

Past Partnerships

American Academy of Neurology - Axon Registry™

The American Academy of Neurology (ANN) developed the Axon Registry™, an electronic health records database, in 2014 as part of its mission to improve the quality of neurological care and patient outcomes. Yale/YNHH CORE RDAC served as a data analytic center for the Axon Registry, providing support for research start-up activities.

For more information about the Axon Registry™, please visit