CORE's Current Projects

Big Data to Knowledge (BD2K)

Massive data collections derived from millions of daily interactions within the health care system are increasingly available, but we urgently need more advanced tools to support research that can produce better personalized predictions about prognosis and response to treatments; a deeper understanding of the complex factors and their interactions that influence health at the level of the patient, the health system, and society; and more effective methods of causal inference, mitigating bias and error. We also need to find new ways to think about data, while promoting its value for individuals and organizations in the service of promoting better decisions and outcomes. Accordingly, we have assembled a remarkable team of world-class experts with complementary skills who are dedicated to deep collaboration in order to produce high impact methods and tools, primed for widespread use, that will unleash the information potential of data produced as part of routine health care delivery.


Quality Measurement

Our Quality Measurement Group's ongoing work with the Centers for Medicare & Medicaid Services (CMS) includes new measure development, research on hospital quality including evaluation of trends, disparities and geographic variation and communications with stakeholders about hospital quality, and potential expansion of outcomes measures to other health care settings.


YODA Project

The YODA Project advocates for the responsible sharing of clinical research data. The Project is committed to open science and data transparency, and supports research attempting to produce concrete benefits to patients, the medical community, and society as a whole. Through experience and input from the public and stakeholders, the YODA Project has iteratively developed a model to make data available to researchers in a sustainable way, in which data sharing becomes a part of the clinical research enterprise of the future. The mission of the YODA Project is to not only increase access to clinical research data, but to promote its use to generate new knowledge.


CRIT

The Collaboration for Research Integrity and Transparency (CRIT) is an inter-disciplinary initiative launched in 2016 to enhance the quality and transparency of the research base for medical products.  Through research, advocacy, and litigation, CRIT is focused on ensuring that the clinical evidence that supports and informs our understanding of the safety and effectiveness of pharmaceuticals, medical devices, and other medical products is accurate, comprehensive, accessible, and reliable.  The lack of transparency and integrity in clinical research has had serious consequences for patient and clinicians.



Medical Device Surveillance Project

The surveillance of medical devices is intended to provide critical information to all relevant stakeholders about device safety, long-term product performance, and effectiveness in improving patient outcomes. However, we are far from this ideal system. Instead, we rely largely upon voluntary reporting systems from providers, health care facility networks, industry, and claims-based or other health care practice databases to characterize risks and benefits of devices in the post-approval environment. There are many shortcomings of these current surveillance systems, and there are no common methods to define the safety signals or the underlying relationships between device, or machine, failure and clinical events. Current analytical approaches typically fail to leverage the complexity and high-dimensionality of health care data sets and single registry efforts are inefficient and not scalable. Electronic health record or claims-based systems currently do not contain the detail needed for longitudinal device evaluation and patient follow-up with outcome assessment.


Global Health

The Yale-CORE China Project's mission is to improve health and health care through international friendship, research-generation, and knowledge application. We strive to leverage the strengths of the US and China, through partnership and friendship, to foster meaningful collaboration and mutual understanding-and promote medical and public health advances. We are committed to expanding the scientific knowledge base, accelerating medical breakthroughs and cures, and sharing our findings with a global audience so that what we learn may benefit our countries and the world.


ACC Analytic Center

Since 2007, Yale CORE has served as a data analytic center (DAC) for the ICD RegistryTM and the CathPCI Registry® of the American College of Cardiology Foundation's National Cardiovascular Data Registry (NCDR®). More recently, NCDR's ACTION Registry®, LAAO RegistryTM and Afib Ablation Registry TM were added to the stable of Yale CORE NCDR registries. The goal of this work is to generate new knowledge and insights into the care of patients with cardiovascular disease through analysis of the robust data submitted to the NCDR® registries. A team of CORE researchers work closely with NCDR® staff to provide logistical and analytical support for research proposals related to its ICD Registry®, CathPCI RegistryTM, ACTION Registry®, LAAO RegistryTM and Afib Ablation Registry TM.


Yale University-Mayo Clinic CERSI

The Yale University-Mayo Clinic Center of Excellence in Regulatory Science and Innovation (CERSI) is a joint effort between Yale University, Mayo Clinic, and the U.S. Food and Drug Administration (FDA) to create infrastructure for regulatory science knowledge generation, conduct research to address key gaps in knowledge, and develop tools to support regulatory decision-making and the overall mission of FDA.


Yale COMET Project

The Yale Collaboration to Optimize Medical Evidence and Transparency (COMET) Project was formed to serve as a trusted intermediary and provide transparent recommendations on clinical research design and medical product evidence generation. As an effort by academically-based clinical researchers, the Yale COMET Project operates independently of regulators, manufacturers and payers to serve the best interests of patients and the public, while respecting concerns of other stakeholders. An independent organization creates a separation from stakeholders that builds trust in the process, strengthens its integrity, and reduces opportunities for real or perceived influence. We provide fair and impartial assessments of what is needed to advance medical therapeutic and technology evaluation.