2024
Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer
Kunst N, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Rabil M, Ghaffar U, Karnes R, Ma X, Gross C, Wang S, Leapman M. Long-Term Outcomes of Prostate-Specific Membrane Antigen–PET Imaging of Recurrent Prostate Cancer. JAMA Network Open 2024, 7: e2440591. PMID: 39441595, PMCID: PMC11581571, DOI: 10.1001/jamanetworkopen.2024.40591.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansMaleMiddle AgedNeoplasm Recurrence, LocalPositron-Emission TomographyProstate-Specific AntigenProstatic NeoplasmsRetrospective StudiesConceptsProstate-specific antigenProstate-specific antigen levelPSMA-PETRecurrent prostate cancerBiochemical recurrenceProstate cancerLong-term outcomesProstate-specific membrane antigen positron emission tomographyEvaluation of biochemical recurrenceDetection of biochemical recurrenceLife yearsConventional imagingDefinitive local therapyPSMA PET imagingProstate cancer deathDetection of metastasesRetrospective cohort studyBase case analysisIncremental life-yearsPositron emission tomographyDecision-analytic modelLocal therapyConventional imaging strategiesDelayed treatmentDisease courseImmunotherapy utilization patterns in patients with advanced cancer and autoimmune disease
Li H, Huntington S, Gross C, Wang S. Immunotherapy utilization patterns in patients with advanced cancer and autoimmune disease. PLOS ONE 2024, 19: e0300789. PMID: 38625861, PMCID: PMC11020359, DOI: 10.1371/journal.pone.0300789.Peer-Reviewed Original ResearchMeSH KeywordsAutoimmune DiseasesCarcinoma, Non-Small-Cell LungFemaleHumansImmunotherapyKidney NeoplasmsLung NeoplasmsMaleRetrospective StudiesConceptsAutoimmune diseasesImmunotherapy cycleFirst-lineNon-small cell lung cancerAdvanced cancerFirst-line immunotherapyOverall treatment toleranceCell lung cancerRenal cell carcinomaRetrospective cohort studyAssociated with lower oddsAdvanced melanomaCell carcinomaTreatment toleranceAbsolute contraindicationImmunotherapyConsensus guidelinesImprove cancer survivalLung cancerCohort studyClinical variablesCancer patientsAcademic centersPatientsIncidence rate
2021
Associations Between Health Literacy and End-of-Life Care Intensity Among Medicare Beneficiaries
Luo Q, Shi K, Hung P, Wang SY. Associations Between Health Literacy and End-of-Life Care Intensity Among Medicare Beneficiaries. American Journal Of Hospice And Palliative Medicine® 2021, 38: 626-633. PMID: 33472379, DOI: 10.1177/1049909120988506.Peer-Reviewed Original ResearchMeSH KeywordsAgedHealth LiteracyHospital MortalityHumansMedicareRetrospective StudiesTerminal CareUnited StatesConceptsAggressive EOL careLow health literacyEOL careHealth literacyMedicare beneficiariesHospital deathCare intensityHigher oddsEOL care intensityLife care intensityPatient-provider communicationProportion of decedentsMonths of lifeDays of lifeHospice enrollmentHL scoreMultivariable analysisHospice useCare measuresRetrospective analysisLife careMedicare feeService decedentsDecedentsCareEnd-of-life patterns of symptom management and cancer-directed care among Medicare beneficiaries with lung cancer: a claims-based analysis
Davidoff AJ, Canavan ME, Prsic E, Saphire M, Wang SY, Presley CJ. End-of-life patterns of symptom management and cancer-directed care among Medicare beneficiaries with lung cancer: a claims-based analysis. Supportive Care In Cancer 2021, 29: 3921-3932. PMID: 33389087, DOI: 10.1007/s00520-020-05964-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHumansLung NeoplasmsMaleMedicareRetrospective StudiesTerminal CareUnited StatesConceptsCancer-directed therapySymptom management servicesLung cancerMedicare beneficiariesCare contentYounger ageEarlier hospice enrollmentLife care patternsLung cancer decedentsPercentage of patientsClaims-based analysisMethodsThis retrospective studyMost Medicare beneficiariesNonhospice settingsCancer decedentsUsual careHospice enrollmentSymptom managementRetrospective studyMedicare databaseSkilled nursingHigh comorbidityCare intensityMedicare claimsMultinomial logistic regression
2020
Changes in community mental health services availability and suicide mortality in the US: a retrospective study
Hung P, Busch SH, Shih YW, McGregor AJ, Wang S. Changes in community mental health services availability and suicide mortality in the US: a retrospective study. BMC Psychiatry 2020, 20: 188. PMID: 32334552, PMCID: PMC7183673, DOI: 10.1186/s12888-020-02607-y.Peer-Reviewed Original ResearchConceptsSuicide mortalityNational Mental Health Services SurveySuicide deathsMental health service availabilityHealth service availabilityMental health servicesMental health careHealth Services SurveySuicide prevention effortsMethodsRetrospective analysisRetrospective studyOutpatient settingHealth servicesDisease controlResultsFrom 2014Same time periodEpidemiologic researchCMHCsPrevention effortsMortalityHealth careServices SurveySuicide ratesAssociationDeath
2019
Racial Differences in Health Care Transitions and Hospice Use at the End of Life
Wang SY, Hsu SH, Aldridge MD, Cherlin E, Bradley E. Racial Differences in Health Care Transitions and Hospice Use at the End of Life. Journal Of Palliative Medicine 2019, 22: 619-627. PMID: 30615546, PMCID: PMC6533794, DOI: 10.1089/jpm.2018.0436.Peer-Reviewed Original ResearchConceptsHealth care transitionCare transitionsEnd of lifeHospice enrollmentHospice useLife careEthnic differencesAfrican AmericansRetrospective cohort studyMonths of lifeRace/ethnic groupsPatterns of endHospice disenrollmentCohort studyNonwhite patientsWhite patientsHospice enrolleesRacial/Ethnic DifferencesMedicare beneficiariesHospice usersDisenrollment ratesMean numberRacial differencesCareAsian Americans
2017
Associations of Hospice Disenrollment and Hospitalization With Continuous Home Care Provision
Wang SY, Dang W, Aldridge MD, Canavan M, Cherlin E, Bradley E. Associations of Hospice Disenrollment and Hospitalization With Continuous Home Care Provision. Medical Care 2017, 55: 848-855. PMID: 28692573, PMCID: PMC5554087, DOI: 10.1097/mlr.0000000000000776.Peer-Reviewed Original ResearchThe Impact of Social Contagion on Physician Adoption of Advanced Imaging Tests in Breast Cancer
Pollack CE, Soulos PR, Herrin J, Xu X, Christakis NA, Forman HP, Yu JB, Killelea BK, Wang SY, Gross CP. The Impact of Social Contagion on Physician Adoption of Advanced Imaging Tests in Breast Cancer. Journal Of The National Cancer Institute 2017, 109: djw330. PMID: 28376191, PMCID: PMC6059114, DOI: 10.1093/jnci/djw330.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingBaseline usePositron emission tomography scanEnd Results-MedicareEmission tomography scanBreast cancer practiceImaging modalitiesAdvanced imaging testsHierarchical logistic regression modelsLogistic regression modelsPatient characteristicsUnproven benefitCancer practiceMRI/PETTomography scanBreast cancerMRI useImaging testsClinical practicePET useResonance imagingPET imagingPhysician peersPhysician adoptionBaseline periodRacial and Ethnic Disparities in Oncotype DX Test Receipt in a Statewide Population-Based Study.
Davis BA, Aminawung JA, Abu-Khalaf MM, Evans SB, Su K, Mehta R, Wang SY, Gross CP. Racial and Ethnic Disparities in Oncotype DX Test Receipt in a Statewide Population-Based Study. Journal Of The National Comprehensive Cancer Network 2017, 15: 346-354. PMID: 28275035, DOI: 10.6004/jnccn.2017.0034.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBreast NeoplasmsConnecticutFemaleGene Expression ProfilingGenetic TestingHealth Services AccessibilityHealthcare DisparitiesHumansLymphatic MetastasisMiddle AgedNeoplasm GradingNeoplasm StagingOdds RatioPatient Outcome AssessmentPopulation SurveillanceRegistriesRetrospective StudiesSocioeconomic FactorsYoung AdultConceptsPopulation-based studyOncotype DXODX testingBreast cancerHispanic womenHormone receptor-positive breast cancerReceptor-positive breast cancerRetrospective population-based studyWhite womenRacial disparitiesGEP test resultsBreast cancer careBreast cancer outcomesStudy inclusion criteriaGene expression profiling testsMore white womenClinical characteristicsTest receiptCancer outcomesCancer careInclusion criteriaLogistic analysisEthnic disparitiesStatewide populationWomen
2016
Continuous Home Care Reduces Hospice Disenrollment and Hospitalization After Hospice Enrollment
Wang SY, Aldridge MD, Canavan M, Cherlin E, Bradley E. Continuous Home Care Reduces Hospice Disenrollment and Hospitalization After Hospice Enrollment. Journal Of Pain And Symptom Management 2016, 52: 813-821. PMID: 27697564, PMCID: PMC5154927, DOI: 10.1016/j.jpainsymman.2016.05.031.Peer-Reviewed Original ResearchConceptsHospice disenrollmentHospice enrollmentPatient characteristicsContinuous home careCHC utilizationMinority of patientsHome careMore comorbiditiesMultivariable analysisMultivariable modelHospice carePatientsHospitalizationService MedicareHospice agenciesHospiceDisenrollmentExpensive careStudy periodCareEnrollmentAssociationComorbiditiesCancerPreoperative breast magnetic resonance imaging and contralateral breast cancer occurrence among older women with ductal carcinoma in situ
Wang SY, Long JB, Killelea BK, Evans SB, Roberts KB, Silber A, Gross CP. Preoperative breast magnetic resonance imaging and contralateral breast cancer occurrence among older women with ductal carcinoma in situ. Breast Cancer Research And Treatment 2016, 158: 139-148. PMID: 27287780, PMCID: PMC5554869, DOI: 10.1007/s10549-016-3858-0.Peer-Reviewed Original ResearchConceptsContralateral breast cancerMagnetic resonance imagingPreoperative magnetic resonance imagingDuctal carcinomaMRI usePreoperative breast magnetic resonance imagingEnd Results-Medicare datasetInvasive contralateral breast cancerOccult contralateral breast cancerResonance imagingSynchronous contralateral breast cancerImpact of MRIStage-specific incidence ratesPreoperative MRI useBreast magnetic resonance imagingBreast cancer occurrenceCBC eventsCBC ratesCumulative incidencePropensity score approachIncidence rateInvasive diseaseBreast cancerCancer occurrenceOlder womenTransitions Between Healthcare Settings of Hospice Enrollees at the End of Life
Wang SY, Aldridge MD, Gross CP, Canavan M, Cherlin E, Johnson-Hurzeler R, Bradley E. Transitions Between Healthcare Settings of Hospice Enrollees at the End of Life. Journal Of The American Geriatrics Society 2016, 64: 314-322. PMID: 26889841, PMCID: PMC4762182, DOI: 10.1111/jgs.13939.Peer-Reviewed Original ResearchConceptsMonths of lifeSkilled nursing facilitiesHospice enrollmentHealthcare settingsNursing facilitiesHospice usersHospital-based palliative careRetrospective cohort studyHome health agenciesEnd of lifeCohort studyPalliative careCare transitionsHospice enrolleesHealthcare transitionHigher oddsClaims dataHospice decedentsMedicare beneficiariesHospice programsHospiceHealth agenciesCareNotable proportionDecedents
2015
Geographic Variation of Hospice Use Patterns at the End of Life
Wang SY, Aldridge MD, Gross CP, Canavan M, Cherlin E, Johnson-Hurzeler R, Bradley E. Geographic Variation of Hospice Use Patterns at the End of Life. Journal Of Palliative Medicine 2015, 18: 771-780. PMID: 26172615, PMCID: PMC4696438, DOI: 10.1089/jpm.2014.0425.Peer-Reviewed Original ResearchThe Role of Patient Factors, Cancer Characteristics, and Treatment Patterns in the Cost of Care for Medicare Beneficiaries with Breast Cancer
Xu X, Herrin J, Soulos PR, Saraf A, Roberts KB, Killelea BK, Wang SY, Long JB, Wang R, Ma X, Gross CP. The Role of Patient Factors, Cancer Characteristics, and Treatment Patterns in the Cost of Care for Medicare Beneficiaries with Breast Cancer. Health Services Research 2015, 51: 167-186. PMID: 26119176, PMCID: PMC4722219, DOI: 10.1111/1475-6773.12328.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBreast NeoplasmsComorbidityFemaleHealth ExpendituresHumansMedicareRetrospective StudiesSEER ProgramSocioeconomic FactorsUnited StatesConceptsBreast cancer careHospital referral regionsCancer careMedicare expendituresBreast cancerRadiation therapyTreatment factorsMean Medicare expendituresEnd Results-MedicareSpecific treatment modalitiesContribution of patientCost of careHighest spending quintilePatient factorsTreatment patternsTumor characteristicsCancer characteristicsTreatment modalitiesReferral regionsMedicare beneficiariesQuintilePatientsCancerCareTherapy