O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity
Abstract Excessive visceral fat accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases. The visceral fat is highly susceptible to the availability of external nutrients. Moreover, adipose OGT overexpression inhibits lipolysis and promotes diet-induced obesity. These findings establish an essential role for OGT in adipose tissue homeostasis and indicate a unique potential for targeting O-GlcNAc signaling in the treatment of obesity.
Molecular ‘Doormen’ Open the Way to Potential Obesity Treatment
In obese individuals, cellular "doormen" open the gates far too wide in certain key fat cells, known as visceral fat cells, letting in too many carbohydrates without first burning off lipids. This leads to a ballooning of the size of visceral fat cells in the belly.
Molecular ‘doormen’ open the way to potential obesity treatment
Fat cells are filled with droplets coated by molecules that act like hotel doormen: These “doormen” control cellular access for nutrients as well as for the exit of energy-supplying molecules called lipids. In healthy individuals, outgoing and incoming traffic in fat cells is finely balanced, supplying energy while preventing excessive spread of undesirable fat in the belly.
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis
A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation.
Yale-led study finds surprise link between metabolism and immunity
In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation.
Vishwa Deep Dixit appointed the Von Zedtwitz Professor of Comparative Medicine
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
Two brain neuroscience: understanding our social selves
Humans are innately sociable mammals. However, almost all of our understanding of the neural basis of social interaction has been carried out with individual participants, limiting our knowledge of how our brains react to other humans. Joy Hirsch, Professor of Neuroscience at the Yale School of Medicine and University College London, has embarked on a truly pioneering research programme using new neuroimaging technology to study the human brain as it interacts with others.
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Blavatnik Fund awards grants for innovation
Several faculty members won research grants from the Blavatnik Fund for Innovation at Yale at the fourth annual Yale Innovation Summit on May 10. The summit, presented by the Office of Cooperative Research (OCR) and Yale Entrepreneurial Institute, provides a window into an expanding entrepreneurial ecosystem at Yale.
Could a ketogenic diet alleviate gout?
More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, neutrophils. These periods of immune reactivation are known as flares, and are driven by a protein complex called the NLRP3 inflammasome.
Can a cancer drug treat a rare cardiac disease?
A study by a Yale scientis suggests that dasatinib and similar drugs at low doses could be effective treatment for cardiovascular defects related to Noonan syndrome (NS), a genetic disorder that results in severe heart defects, and should be considered for clinical trials.
Yale Researchers Study Life-Extending Hormone
Beginning in 2007, Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine, and a team of researchers at his lab began studying the hormone and its effects on mice genetically engineered to produce more of it.
Webcast: Tamas L. Horvath DVM, PhD ADA 76th scientific sessions Outstanding Scientific Achievement Award Lecture- "Hunger-promoting Hypothalamic Neurons Control Systemic Metabolism and Drive Complex Behaviors and Longevity"
Tamas L. Horvath DVM, PhD presents at the ADA 76th scientific sessions Outstanding Scientific Achievement Award Lecture on June 13, 2016 in New Orleans, LA.
Constipated? Study finds surprising cause
A Yale-led study has shown a surprising link between constipation and herpes infection. The finding, published June 8 in Cell Host & Microbe, advances the science on herpes, and could help patients with chronic gastrointestinal diseases with no clear cause.