Vishwa Deep Dixit appointed the Von Zedtwitz Professor of Comparative Medicine
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Could a ketogenic diet alleviate gout?
More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, neutrophils. These periods of immune reactivation are known as flares, and are driven by a protein complex called the NLRP3 inflammasome.
Yale Researchers Study Life-Extending Hormone
Beginning in 2007, Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine, and a team of researchers at his lab began studying the hormone and its effects on mice genetically engineered to produce more of it.Source: Connecticut
Life-extending hormone bolsters the body’s immune function
A hormone that extends lifespan in mice by 40% is produced by specialized cells in the thymus gland, according to a new study by Yale School of Medicine researchers. The team also found that increasing the levels of this hormone, called FGF21, protects against the loss of immune function that comes with age.
Anti-inflammatory mechanism of dieting and fasting revealed
Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease.
Research in the news: Yale team uncovers genetic trigger for immune response
The thousands of mitochondrial DNA (mtDNA) molecules present in each cell are known primarily for their role converting food and oxygen into energy. But Yale researchers have identified an unexpected relationship between mtDNA and the innate immune response.
Women's Health in the Time of COVID-19 Webinar
Uncovering how the coronavirus affects the biology of women and men differently is teaching us new ways to fight COVID-19. Identifying how the stress of the pandemic is different for women and men is focusing mental health professionals on risk and resilience. Watch Women’s Health Research at Yale Director Carolyn M. Mazure, Ph.D, and leading immunologist Akiko Iwasaki, Ph.D., in conversation with Yale Medalist Susanna Krentz, '80, as they discuss a major new research finding and next steps in investigating sex differences to advance the health of women and men.
Why Is COVID-19 Striking Men Harder Than Women?
Women's Health Research at Yale Director Carolyn M. Mazure and Immunobiology Professor Akiko Iwasaki, discuss how understanding why men suffer more severe cases of COVID-19 and are more likely to die is vital for developing effective strategies that can produce better outcomes for everyone.Source: Time
How T Cells Make Sure They Have Quiet Time
All cells, like all people, need “quiet” time to function properly, and this is particularly true of T cells, one of the immune system’s main weapons. They must be ready for activation at all times, and primed to divide more rapidly than almost any cell in the body.
The harmful effects of stress during pregnancy can last a lifetime
Mice exposed to stress in the womb and soon after birth can expect a lifetime of immune system deficiencies that hinder the ability to ward off infections and cancer, Yale University researchers report March 5 in the journal Cell.
From Paradox to Breakthrough
Aaron Ring, MD, PhD, was hooked by a paradox. He had been studying cytokines to understand their potential to stimulate anti-tumor immunity. Though cytokines, such as interleukin-2, have been in clinical use for decades, they have historically shown only limited effectiveness. Dr. Ring was hunting for interleukins that could deliver a specific signal to activate TILs.
Richard Flavell Is Named a Distinguished Fellow by the American Association of Immunologists
Richard A. Flavell, PhD, is one of 20 scientists who have been named Distinguished Fellows by the American Association of Immunologists, which recognizes members for distinguished careers and outstanding scientific contributions, as well as their service to AAI and the immunology community. It is one of the highest honors that AAI bestows.