Yale-led study finds surprise link between metabolism and immunity
In the search for obesity treatments, scientists recently zeroed in on a gene known as Nucleobindin-2 (Nucb2), which was believed to play a role in satiety. However, in a new study published in Cell Reports, Yale researchers uncovered an unexpected function for the gene in reducing inflammation.
Vishwa Deep Dixit appointed the Von Zedtwitz Professor of Comparative Medicine
Vishwa Deep Dixit, newly named as the Waldemar Von Zedtwitz Professor of Comparative Medicine, studies the interaction between immune and metabolic systems with the goal of revealing targets that can be harnessed to extend the healthspan — the period of life that is free of disabilities and disease.
Two brain neuroscience: understanding our social selves
Humans are innately sociable mammals. However, almost all of our understanding of the neural basis of social interaction has been carried out with individual participants, limiting our knowledge of how our brains react to other humans. Joy Hirsch, Professor of Neuroscience at the Yale School of Medicine and University College London, has embarked on a truly pioneering research programme using new neuroimaging technology to study the human brain as it interacts with others.Source: Research Features
Battling belly fat: Specialized immune cells impair metabolism in aging
In a new study, Yale researchers have described how nervous systems and immune systems talk to each other to control metabolism and inflammation. Their finding furthers scientists’ understanding of why older adults fail to burn stored belly fat, which raises the risk of chronic disease. The study also points to potential therapeutic approaches to target the problem, the researchers said.
Blavatnik Fund awards grants for innovation
Several faculty members won research grants from the Blavatnik Fund for Innovation at Yale at the fourth annual Yale Innovation Summit on May 10. The summit, presented by the Office of Cooperative Research (OCR) and Yale Entrepreneurial Institute, provides a window into an expanding entrepreneurial ecosystem at Yale.
Could a ketogenic diet alleviate gout?
More than 8 million individuals in the United States have gout, a disease that can cause intense recurrent episodes of debilitating pain, inflammation, and fever. The cause of gout is the accumulation of urate crystals in joints, which continuously reactivate the immune system, leading to activation of the most common type of immune cell in the blood, neutrophils. These periods of immune reactivation are known as flares, and are driven by a protein complex called the NLRP3 inflammasome.
Can a cancer drug treat a rare cardiac disease?
A study by a Yale scientis suggests that dasatinib and similar drugs at low doses could be effective treatment for cardiovascular defects related to Noonan syndrome (NS), a genetic disorder that results in severe heart defects, and should be considered for clinical trials.
Yale Researchers Study Life-Extending Hormone
Beginning in 2007, Vishwa Deep Dixit, professor of comparative medicine and immunobiology at Yale School of Medicine, and a team of researchers at his lab began studying the hormone and its effects on mice genetically engineered to produce more of it.Source: Connecticut
Webcast: Tamas L. Horvath DVM, PhD ADA 76th scientific sessions Outstanding Scientific Achievement Award Lecture- "Hunger-promoting Hypothalamic Neurons Control Systemic Metabolism and Drive Complex Behaviors and Longevity"
Tamas L. Horvath DVM, PhD presents at the ADA 76th scientific sessions Outstanding Scientific Achievement Award Lecture on June 13, 2016 in New Orleans, LA.Source: ADA
Constipated? Study finds surprising cause
A Yale-led study has shown a surprising link between constipation and herpes infection. The finding, published June 8 in Cell Host & Microbe, advances the science on herpes, and could help patients with chronic gastrointestinal diseases with no clear cause.
A mouse’s house may ruin experiments
It’s no secret that therapies that look promising in mice rarely work in people. But too often, experimental treatments that succeed in one mouse population do not even work in other mice, suggesting that many rodent studies may be flawed from the start.Source: A mouse’s house may ruin experiments
Life-extending hormone bolsters the body’s immune function
A hormone that extends lifespan in mice by 40% is produced by specialized cells in the thymus gland, according to a new study by Yale School of Medicine researchers. The team also found that increasing the levels of this hormone, called FGF21, protects against the loss of immune function that comes with age.
Yale researcher honored for diabetes research
Matthew Rodeheffer, associate professor of comparative medicine, was honored at the third annual Helmholtz-Nature Medicine Diabetes Conference in Munich on Sept. 21 for his groundbreaking research into how fat mass can lead to diabetes and heart disease.
Researchers Identify Cellular Origins of Fat
A study led by Ryan Berry GRD ’15 and associate research scientist Matthew Rodeheffer from the Yale School of Medicine determined that a specific type of cell, the CD24+ cell, differentiates into fat cells in mice. This development answers many questions regarding the origins of body fat, which is the key factor in highly prevalent conditions such as diabetes and obesity.Source: The Yale Daily News
New fat cells created quickly, but losing them …
Once fat cells form, they might shrink during weight loss, but they do not disappear, a fact that has derailed many a diet. Yale researchers in the March 2 issue of the journal Nature Cell Biology describe how — and just how quickly — those fat cells are created in the first place.