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Clinical Investigation

Photo by Kristin Hynes
Yale School of Medicine investigators led trials of the COVID-19 Pfizer-BioNTech vaccine in adults and children, and Remdesivir, a therapeutic drug used to treat the disease.
Clinical investigation at Yale bridges the gap between the basic and translational sciences and the practice of medicine. Research is focused on the factors that affect health and illness in populations, the evaluation of therapeutic interventions, and the assessment of health outcomes based on analysis of large data sets. The School of Medicine sponsors a wide range of clinical trials, with more than 1,868 active trials in 2020 and over 11,000 “Help Us Discover” unique volunteers enrolled (see and 27,884 active subjects. The school offers superb training for clinical investigators in a number of settings, including the Yale Center for Clinical Investigation, the National Clinician Scholars Program at Yale (the evolution of the Robert Wood Johnson Foundation Clinical Scholars Program), the Yale School of Public Health, and the Investigative Medicine Program, along with discipline-specific training initiatives in selected departments.

The Yale Center for Clinical Investigation facilitates the training of clinical and translational scientists and provides infrastructure for innovative and collaborative research directed at improving patient care. It funds up to 20 YCCI Scholars yearly and supports investigators in the areas of biostatistics, bioinformatics, study design, core technologies, regulatory review, patient recruitment, and community-based research.


  • The National Clinician Scholars Program at Yale was established in 2016 to prepare future clinician leaders to improve health and health care. Graduates of the two-year interprofessional fellowship earn a master of health sciences (MHS) degree.
  • Yale School of Public Health offers training and conducts research in biostatistics, chronic disease epidemiology, environmental health sciences, epidemiology of microbial diseases, and health policy and administration.
  • The Investigative Medicine Program awards a PhD degree to holders of MD degrees who pursue training in either laboratory-based or clinically based human investigation.

By the Numbers
Benchmark Total
RWJ Scholars since 1974 187
NCSP Scholars since 2016 35
PhDs awarded by Investigative Medicine Program since 2003 48
YCCI Scholars trained since 2006 152