Clinical Trial Builds Upon Yale Studies to Provide Proof-of-Concept that Subtype-specific Sodium Channel Blockers can Reduce Pain in Humans
Pain is a pervasive symptom encountered by physicians worldwide and a longstanding medical challenge, particularly against the backdrop of the opioid crisis.
Perspective: Prospects for Pain
Some types of pain have proven resistant to all available medications. In this episode of “Intention to Treat,” Rachel Gotbaum talks with a patient with neuropathic pain and a researcher exploring new sodium-channel blockers that offer promise for such patients.Source: The New England Journal of Medicine
NIH Awards HEAL Grant to Study Novel Ways to Treat Pain
A team of researchers—including Yale School of Medicine’s Sulayman D. Dib-Hajj, PhD, senior research scientist in neurology, Stephen G. Waxman, MD, PhD, professor of neurology, and Lakshmi Bangalore, PhD, lecturer in neurology—has been awarded funding through the NIH HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development.
Yale scientists repair injured spinal cord using patients’ own stem cells
Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Journal of Clinical Neurology and Neurosurgery.Source: Yale News
New ways to help people avoid opioid overdose and beat addiction
This is just one example of how Yale School of Medicine researchers and clinicians are pursuing innovations that could both improve treatment of opioid addiction and introduce new painkillers that are effective yet not addictive.Source: Yale Medicine
Nav1.7: a new channel for pain treatment
Following intriguing genetic discoveries in people with extreme sensitivity to pain, as well as some families who feel no pain at all, researchers and drug companies are optimistic that blocking a sodium channel called Nav1.7 may lead to a new generation of more sophisticated painkillers. Meanwhile, however, there is still debate about the underlying mechanism of Nav1.7 in pain.Source: The Pharmaceutical Journal
In a world of chronic pain, individual treatment possible, Yale research shows
An investigation into the molecular causes of a debilitating condition known as “Man on Fire Syndrome” has led Yale researchers to develop a strategy that may lead to personalized pain therapy and predict which chronic pain patients will respond to treatment.
Yale team discovers unexpected source of diabetic neuropathy pain
Nearly half of all diabetics suffer from neuropathic pain, an intractable, agonizing and still mysterious companion of the disease. Now Yale researchers have identified an unexpected source of the pain and a potential target to alleviate it.
Yale Researchers Uncover Source of Mystery Pain
An estimated 20 million people in the United States suffer from peripheral neuropathy, marked by the degeneration of nerves and in some cases severe pain. There is no good treatment for the disorder and doctors can find no apparent cause in one of every three cases.