2024
The Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT
Miller R, Lemley M, Shanbhag A, Bednarski B, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated REgistry of Fast Myocardial Perfusion Imaging With NExt Generation SPECT. Journal Of Nuclear Cardiology 2024, 38: 101926. DOI: 10.1016/j.nuclcard.2024.101926.Peer-Reviewed Original ResearchAutomating Revascularization Decision Support: Clinical Application of Artificial Intelligence
Zhang W, Miller R, Patel K, Shanbhag A, Liang J, DiCarli M, Dorbala S, Einstein A, Fish M, Hauser M, Kaufmann P, Miller E, Ruddy T, Bateman T, Martins M, Sharir T, Halcox J, Acampa W, Dey D, Berman D, Slomka P. Automating Revascularization Decision Support: Clinical Application of Artificial Intelligence. Journal Of Nuclear Cardiology 2024, 38: 102001. DOI: 10.1016/j.nuclcard.2024.102001.Peer-Reviewed Original ResearchFrom transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics
Walenczyk K, Singh A, Tong K, Burg M, Miller E. From transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics. American Journal Of Health-System Pharmacy 2024, zxae183. PMID: 38963826, DOI: 10.1093/ajhp/zxae183.Peer-Reviewed Original ResearchPatient sociodemographic characteristicsATTR-CASociodemographic characteristicsSpecialty pharmacyPyrophosphate scintigraphyPopulation prevalence ratesEconomically disadvantaged areasTransthyretin cardiac amyloidosisBlack/African American raceReduce disparitiesPotential patient subgroupsPharmacy processesProportion of daysClinical pathwayCompare sociodemographicsDisadvantaged areasEquitable provisionTafamidis therapyCardiac amyloidosisTafamidis treatmentPrevalence ratesClinical programsAmerican racePatient subgroupsPosting manuscriptsReproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients
Sandoval V, Goyal D, Miller E, Liu Y. Reproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.047. DOI: 10.1093/ehjci/jeae142.047.Peer-Reviewed Original ResearchStandardized uptake valueTc-99m PYP uptakeTc-99Cardiac amyloidosisHeart failureStandard uptake value quantificationStandardized uptake value calculationSPECT imagesIntractable heart failureSystolic heart failureIntroduction of therapyPlanar imagingTc-99m pyrophosphateAmyloid patientsSPECT/CT imagingInter-reproducibilityUptake valueContralateral ratioCoefficient of variationDisease progressionH/M ratioGrade 1Blood poolPatientsH/CL ratioEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategiesAddressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
Maurer M, Miller E, Ruberg F. Addressing Health Disparities—The Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger. JAMA 2024, 331: 1809-1811. PMID: 38734953, DOI: 10.1001/jama.2024.2868.Peer-Reviewed Original ResearchLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaUnlocking Diversity in Cardiovascular Clinical Research: Lessons from the SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) Study
Wardhere A, Bampatsias D, Cohn E, Fine D, Freitas C, Gallegos C, Helmke S, Ionescu N, Ivrose J, Rodriguez C, Sabogal N, Fils S, Henry T, Teruya S, Ullah I, Kurian D, Raiszadeh F, Miller E, Ruberg F, Maurer M. Unlocking Diversity in Cardiovascular Clinical Research: Lessons from the SCAN-MP (Screening for Cardiac Amyloidosis with Nuclear Imaging in Minority Populations) Study. Journal Of Cardiac Failure 2024 PMID: 38740174, DOI: 10.1016/j.cardfail.2024.04.019.Peer-Reviewed Original ResearchTAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction
Guo X, Shi L, Chen X, Liu Q, Zhou B, Xie H, Liu Y, Palyo R, Miller E, Sinusas A, Staib L, Spottiswoode B, Liu C, Dvornek N. TAI-GAN: A Temporally and Anatomically Informed Generative Adversarial Network for early-to-late frame conversion in dynamic cardiac PET inter-frame motion correction. Medical Image Analysis 2024, 96: 103190. PMID: 38820677, PMCID: PMC11180595, DOI: 10.1016/j.media.2024.103190.Peer-Reviewed Original ResearchGenerative adversarial networkAdversarial networkMotion estimation accuracyInter-frame motionIntensity-based image registration techniqueAll-to-oneSegmentation masksImage registration techniquesOriginal frameTemporal informationDiagnosis accuracyMyocardial blood flowEstimation accuracyFrame conversionPositron emission tomographyNovel methodImage qualityPET datasetsRegistration techniqueNetworkCardiac positron emission tomographyBlood flowDynamic cardiac positron emission tomographyMotion correctionCoronary artery diseaseReal-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study
Oikonomou E, Aminorroaya A, Dhingra L, Partridge C, Velazquez E, Desai N, Krumholz H, Miller E, Khera R. Real-world evaluation of an algorithmic machine-learning-guided testing approach in stable chest pain: a multinational, multicohort study. European Heart Journal - Digital Health 2024, 5: 303-313. PMID: 38774380, PMCID: PMC11104476, DOI: 10.1093/ehjdh/ztae023.Peer-Reviewed Original ResearchRisk of acute myocardial infarctionAssociated with lower oddsHospital health systemCoronary artery diseaseCardiac testingRisk of adverse outcomesUK BiobankHealth systemProvider-drivenLower oddsAssociated with better outcomesAcute myocardial infarctionBlack raceStable chest painFemale sexReal world evaluationDiabetes historyMulticohort studyFunction testsSuspected coronary artery diseaseYounger ageRisk profileAdverse outcomesMultinational cohortPost hoc analysisDeep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging
Shanbhag A, Miller R, Killekar A, Lemley M, Bednarski B, Van Kriekinge S, Kavanagh P, Feher A, Miller E, Bateman T, Liang J, Builoff V, Berman D, Dey D, Slomka P. Deep learning-based epicardial adipose tissue measurement, maximizing prognostic information from attenuation correction imaging. Progress In Biomedical Optics And Imaging 2024, 12930: 129300b-129300b-6. DOI: 10.1117/12.3007914.Peer-Reviewed Original ResearchEpicardial adipose tissueUngated CTMyocardial infarctionEAT volumeRisk stratificationComputed tomographyEAT volume measurementEpicardial adipose tissue measurementsEpicardial adipose tissue volumeAssociated with risk of cardiovascular eventsRisk of cardiovascular eventsMedian follow-upIncreased risk of deathGated computed tomographyImprove risk stratificationAdipose tissue measurementsAssociated with riskRisk of deathAttenuation correction imagesGated CTChest CTNo significant differencePrognostic informationCardiovascular eventsFollow-upTRANSTHYRETIN AMYLOID CARDIOMYOPATHY IS ASSOCIATED WITH WORSE OUTCOMES WHEN COMPARED TO PATIENTS WITH NON-AMYLOID RELATED HEART FAILURE OF SIMILAR RACE AND ETHNICITY: THE SCAN-MP STUDY
Schmidt A, Ullah I, Teruya S, Fine D, Sabogal N, Foster R, Helmke S, Rodriguez C, Spencer B, Winburn M, Bampatsias D, Wardhere A, De Freitas C, Prokaeva T, Kattan C, Miller E, LaValley M, Maurer M, Ruberg F. TRANSTHYRETIN AMYLOID CARDIOMYOPATHY IS ASSOCIATED WITH WORSE OUTCOMES WHEN COMPARED TO PATIENTS WITH NON-AMYLOID RELATED HEART FAILURE OF SIMILAR RACE AND ETHNICITY: THE SCAN-MP STUDY. Journal Of The American College Of Cardiology 2024, 83: 520. DOI: 10.1016/s0735-1097(24)02510-5.Peer-Reviewed Original ResearchA COMPARATIVE ANALYSIS OF PET, CZT SPECT, AND CONVENTIONAL SPECT IN MODERN CARDIOLOGY
Ahmed A, Agarwal R, Khera R, Liu Y, Sinusas A, Miller E, Feher A. A COMPARATIVE ANALYSIS OF PET, CZT SPECT, AND CONVENTIONAL SPECT IN MODERN CARDIOLOGY. Journal Of The American College Of Cardiology 2024, 83: 1365. DOI: 10.1016/s0735-1097(24)03355-2.Peer-Reviewed Original ResearchLACK OF HEMODYNAMIC RESPONSE TO VASODILATOR STRESS IS ASSOCIATED WITH CARDIOVASCULAR EVENTS
Liang J, Miller R, Bednarski B, Lemley M, Shanbhag A, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. LACK OF HEMODYNAMIC RESPONSE TO VASODILATOR STRESS IS ASSOCIATED WITH CARDIOVASCULAR EVENTS. Journal Of The American College Of Cardiology 2024, 83: 1393. DOI: 10.1016/s0735-1097(24)03383-7.Peer-Reviewed Original ResearchArtificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging
Feher A, Bednarski B, Miller R, Shanbhag A, Lemley M, Miras L, Sinusas A, Miller E, Slomka P. Artificial Intelligence Predicts Hospitalization for Acute Heart Failure Exacerbation in Patients Undergoing Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266761. PMID: 38548351, PMCID: PMC11064832, DOI: 10.2967/jnumed.123.266761.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingHF hospitalizationHeart failureStress left ventricular ejection fractionPerfusion imagingHF exacerbationPredictive of HF hospitalizationsSPECT/CT myocardial perfusion imagingMyocardial perfusionInternational cohortAcute heart failure exacerbationMedian follow-upVentricular ejection fractionReceiver-operating-characteristic curveClinical risk factorsHeart failure exacerbationExternal validation cohortAcute HF exacerbationPrevent HF hospitalizationsImaging parametersCalcium scoreEjection fractionClinical parametersCT scanValidation cohortClinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins
De Lillo A, Pathak G, Low A, De Angelis F, Abou Alaiwi S, Miller E, Fuciarelli M, Polimanti R. Clinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins. Human Genomics 2024, 18: 31. PMID: 38523305, PMCID: PMC10962184, DOI: 10.1186/s40246-024-00596-7.Peer-Reviewed Original ResearchConceptsCardiac congenital anomaliesAmyloidogenic mutationsCross-ancestry meta-analysisCongenital anomaliesComplex genotype-phenotype correlationsVal122Ile mutationGenotype-phenotype correlationPeripheral nerve disordersHereditary form of amyloidosisAncestry-specificCross-ancestryEuropean-descent individualsEast AsiansTTR-related amyloidosisIndividuals of African descentPopulation originClinical presentationAtrioventricular blockClinical spectrumDelayed diagnosisTTR mutationsAfrican descentNerve disordersTransthyretin mutationMutationsImpact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography
Randazzo M, Elias P, Poterucha T, Sharir T, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Castillo M, Liang J, Miller R, Dey D, Berman D, Slomka P, Einstein A. Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography. European Heart Journal - Cardiovascular Imaging 2024, 25: 996-1006. PMID: 38445511, PMCID: PMC11210974, DOI: 10.1093/ehjci/jeae055.Peer-Reviewed Original ResearchSPECT myocardial perfusion imagingMyocardial perfusion imagingCoronary artery diseaseCardiac sizeDetect obstructive coronary artery diseasePerfusion imagingObstructive coronary artery diseaseDetection of coronary artery diseaseNegative predictive valueLeft ventricular volumeSolid-state scannersSmall cardiac sizeCoronary angiographyMale patientsYounger patientsElderly patientsMale sexDiagnostic performanceVentricular volumeArtery diseaseVisual assessmentPatientsPredictive valueElderly ageSPECTAI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging
Miller R, Shanbhag A, Killekar A, Lemley M, Bednarski B, Kavanagh P, Feher A, Miller E, Bateman T, Builoff V, Liang J, Newby D, Dey D, Berman D, Slomka P. AI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging. JACC Cardiovascular Imaging 2024, 17: 780-791. PMID: 38456877, PMCID: PMC11222053, DOI: 10.1016/j.jcmg.2024.01.006.Peer-Reviewed Original ResearchComputed tomography attenuation correctionMajor adverse cardiovascular eventsCoronary artery calciumLV massMyocardial perfusion imagingPerfusion imagingSingle-photon emission computed tomography/computed tomographyIncreased risk of MACEAssociated with major adverse cardiovascular eventsRisk of Major Adverse Cardiovascular EventsCardiac chamber volumesMedian follow-upCT-based volumesRight ventricular volumesImprove cardiovascular risk assessmentAdverse cardiovascular eventsQuartile of LV massContinuous net reclassification indexCoronary artery diseaseNet reclassification indexCardiovascular risk assessmentTomography/computed tomographyConsecutive patientsImprove risk predictionPrognostic utilityTotal-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council
Slart R, Bengel F, Akincioglu C, Bourque J, Chen W, Dweck M, Hacker M, Malhotra S, Miller E, Pelletier-Galarneau M, Packard R, Schindler T, Weinberg R, Saraste A, Slomka P. Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266858. PMID: 38388512, DOI: 10.2967/jnumed.123.266858.Peer-Reviewed Original ResearchLong axial fieldAxial fieldCardiovascular diseaseLow-dose examinationsWhole-body coveragePET/CT systemField of cardiovascular diseaseCardiac physiologyAnatomic coveragePET/CT applicationsMultiple organsVascular structuresCardiovascular systemTracer kinetic modelAcquisition timeSimultaneous assessmentSystem sensitivityImage qualityDiseaseAutomated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry
Williams M, Shanbhag A, Zhou J, Michalowska A, Lemley M, Miller R, Killekar A, Waechter P, Gransar H, Van Kriekinge S, Builoff V, Feher A, Miller E, Bateman T, Dey D, Berman D, Slomka P. Automated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry. European Heart Journal - Cardiovascular Imaging 2024, 25: 976-985. PMID: 38376471, PMCID: PMC11210989, DOI: 10.1093/ehjci/jeae045.Peer-Reviewed Original ResearchCoronary artery calcificationRight coronary arteryAttenuation correction CTGated CTAgatston unitsLeft circumflexHazard ratioCoronary artery calcification quantificationMulti-center registryAdverse cardiovascular eventsYear follow-upConfidence intervalsLinear weighted Cohen's kappaPrognostic implicationsMulticenter registryPrognostic assessmentCardiovascular eventsArtery calcificationCoronary arteryAttenuation correctionCohen's kappaLM/LADRegistry