2022
Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease
Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S. Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease. Neurology And Therapy 2022, 11: 265-282. PMID: 35000133, PMCID: PMC8857357, DOI: 10.1007/s40120-021-00318-4.Peer-Reviewed Original ResearchSupplementary motor areaClinical outcomesParkinson's diseaseDBS locationPostoperative MRIBrain stimulationIntroductionDeep brain stimulationMotor symptom improvementPostoperative clinical outcomesIdiopathic PD patientsPrimary motor cortexOptimal clinical outcomesDeep brain stimulationSTN-DBS outcomesSuperior frontal cortexDBS electrode positionUse of MRIUse of DBSSubcortical volumetryDBS outcomesPD patientsSubcortical targetsSymptom improvementDBS surgeryMotor cortex
2019
Cortical network fingerprints predict deep brain stimulation outcome in dystonia
Gonzalez‐Escamilla G, Muthuraman M, Reich M, Koirala N, Riedel C, Glaser M, Lange F, Deuschl G, Volkmann J, Groppa S. Cortical network fingerprints predict deep brain stimulation outcome in dystonia. Movement Disorders 2019, 34: 1537-1546. PMID: 31433874, DOI: 10.1002/mds.27808.Peer-Reviewed Original ResearchConceptsDeep brain stimulationModerate-outcome groupDystonia patientsEffective evidence-based therapySuperior-outcome groupGlobus pallidus internusGrey matter atrophy patternsEvidence-based therapiesBrain network organizationClinical responseCortical atrophyDBS outcomesIndependent predictorsMotor improvementMulticenter cohortDBS implantationAtrophy patternsPreoperative MRITherapy responseVisuomotor areasCortical thicknessBrain stimulationCortical mantlePatientsUnequivocal predictors