2024
Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes
Clementz B, Assaf M, Sweeney J, Gershon E, Keedy S, Hill S, Ivleva E, Tamminga C, McDowell J, Keshavan M, Gibbons R, Carpenter W, Pearlson G. Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes. Advances In Neurobiology 2024, 40: 685-723. PMID: 39562461, DOI: 10.1007/978-3-031-69491-2_23.Peer-Reviewed Original ResearchConceptsIdiopathic psychosisBiotype-1Response to clozapineBipolar-Schizophrenia NetworkContinuum of severityReduced physiological responseDSM diagnosesNeurobiological distinctionsCategorical diagnosisSchizophrenia NetworkDiagnostic boundariesSalient stimuliPsychosis diagnosisPsychosis casesPsychiatric classificationPsychosis dataPsychosisBiotype-2Identified biotypesNeural activityIntermediate phenotypesTreatment targetElectrophysiological biomarkersElectrophysiological measurementsMedical model
2023
Double dissociation between P300 components and task switch error type in healthy but not psychosis participants
Huang L, Parker D, Ethridge L, Hamm J, Keedy S, Tamminga C, Pearlson G, Keshavan M, Hill S, Sweeney J, McDowell J, Clementz B. Double dissociation between P300 components and task switch error type in healthy but not psychosis participants. Schizophrenia Research 2023, 261: 161-169. PMID: 37776647, PMCID: PMC11015813, DOI: 10.1016/j.schres.2023.09.025.Peer-Reviewed Original ResearchConceptsEvent-related potentialsDouble dissociationParietal P300Oddball taskCognitive functionPsychosis participantsInductive reasoningP300 event-related potentialFrontal P300 amplitudePossible neural correlatesMental flexibilityCognitive demandsMemory maintenanceNeural correlatesPerseverative errorsRegressive errorsBehavioral performanceOddball targetsP300 componentP300 amplitudeError typesSubjects' abilityNeural activityP300 reductionHealthy participants
2021
Hippocampal Glutamate, Verbal Episodic Memory and Intrinsic Neural Activity in the Psychosis Spectrum
Bolo N, Zeng V, Clementz B, Tamminga C, Pearlson G, Gershon E, Keshavan M. Hippocampal Glutamate, Verbal Episodic Memory and Intrinsic Neural Activity in the Psychosis Spectrum. Biological Psychiatry 2021, 89: s345. DOI: 10.1016/j.biopsych.2021.02.860.Peer-Reviewed Original ResearchPeripheral Inflammatory Markers Are Associated With Neural Activity During the Auditory Oddball Task
Raymond N, Hudgens-Haney M, Lee A, Keedy S, Tamminga C, Pearlson G, Gershon E, Sweeney J, Keshavan M, Clementz B, Bishop J, Lizano P. Peripheral Inflammatory Markers Are Associated With Neural Activity During the Auditory Oddball Task. Biological Psychiatry 2021, 89: s164. DOI: 10.1016/j.biopsych.2021.02.421.Peer-Reviewed Original Research
2019
Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium
Thomas O, Parker D, Trotti R, McDowell J, Gershon E, Sweeney J, Keshavan M, Keedy S, Ivleva E, Tamminga C, Pearlson G, Clementz B. Intrinsic neural activity differences in psychosis biotypes: Findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Biomarkers In Neuropsychiatry 2019, 1: 100002. PMID: 36643612, PMCID: PMC9837786, DOI: 10.1016/j.bionps.2019.100002.Peer-Reviewed Original ResearchPsychosis biotypesHealthy personsBipolar-Schizophrenia NetworkSingle-trial powerFirst-degree biological relativesNeural activity differencesInter-stimulus intervalBiotype 2Intermediate Phenotypes (B-SNIP) consortiumPsychosis casesEffective treatmentIntrinsic activityPsychosis subgroupsNeural modulationLow intrinsic activityDSM groupNeural activitySocial functioningBiotype characterizationBiological relativesConventional diagnosisIntermediate phenotypesDifferentiating featuresDSM syndromesProbands
2018
9.3 PSYCHOSIS BIOTYPES VERSUS CLINICAL SYNDROMES THROUGH THE PRISM OF INTRINSIC NEURAL ACTIVITY
Clementz B, Pearlson G, Tamminga C, Sweeney J, Keshavan M. 9.3 PSYCHOSIS BIOTYPES VERSUS CLINICAL SYNDROMES THROUGH THE PRISM OF INTRINSIC NEURAL ACTIVITY. Schizophrenia Bulletin 2018, 44: s14-s14. PMCID: PMC5888365, DOI: 10.1093/schbul/sby014.031.Peer-Reviewed Original ResearchInter-trial intervalNeural activityIntrinsic neural activityPsychosis biotypesDSM diagnosesSingle-trial powerOngoing neural activityBipolar-Schizophrenia NetworkHealthy personsStimulus salienceNeural responsesNeural oscillationsB-SNIPNeurobiological similaritiesNeurophysiological modelFirst-degree relativesEEG measuresTreatment developmentSensory cortexTranslational research programClinical featuresDistinct physiological mechanismsHealthy groupPsychosis diagnosisPsychosis cases
2000
A weighted least‐squares algorithm for estimation and visualization of relative latencies in event‐related functional MRI
Calhoun V, Adalı T, Kraut M, Pearlson G. A weighted least‐squares algorithm for estimation and visualization of relative latencies in event‐related functional MRI. Magnetic Resonance In Medicine 2000, 44: 947-954. PMID: 11108633, DOI: 10.1002/1522-2594(200012)44:6<947::aid-mrm17>3.0.co;2-5.Peer-Reviewed Original Research