2024
Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells.
Verma S, Bradley M, Gray J, Dogra P, Caron D, Maurrasse S, Grunstein E, Waldman E, Jang M, Pethe K, Farber D, Connors T. Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells. The Journal Of Immunology 2024, 213: 306-316. PMID: 38905110, PMCID: PMC11304551, DOI: 10.4049/jimmunol.2300890.Peer-Reviewed Original ResearchRegulatory T cellsT cellsTreg biologyCD4+ regulatory T cellsCD8+ T cellsIncreased Foxp3 expressionProportion of TregsProduction of IL-10Paired blood samplesHigher proliferative capacityTranscriptional profilesAdult TregsTreg activityFoxp3 expressionTreg identityExtrafollicular regionsTregsIL-10Primary siteProtective immunityProliferative capacityImmune responseImmunological developmentAdult subjectsImmune system
2023
Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System
Waldman E, Ingram A, Vidrine D, Gould A, Zeiders J, Ow R, Thompson C, Moss J, Mehta R, McClay J, Brenski A, Gavin J, Ansley J, Yen D, Chadha N, Murray M, Kozak F, York C, Brown D, Grunstein E, Sprecher R, Sherman D, Schoem S, Puchalski R, Hills S, Harfe D, England L, Syms C, Lustig L. Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System. Otolaryngology 2023, 169: 692-700. PMID: 37003297, DOI: 10.1002/ohn.336.Peer-Reviewed Original ResearchConceptsEpinephrine iontophoresisTube placementTube retentionOperating roomChildren ages 6 monthsCohort of patientsTwo-Year OutcomesAge 6 monthsDelivery systemComplication rateGeneral anesthesiaLocal anesthesiaOtolaryngology practiceTympanostomyPatientsMonthsIontophoresisTympanic membraneAnesthesiaTube displacementAdditional leadsCohortDelivery resultsOutcomesEar
2021
Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage.
Hegewisch-Solloa E, Seo S, Mundy-Bosse BL, Mishra A, Waldman EH, Maurrasse S, Grunstein E, Connors TJ, Freud AG, Mace EM. Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage. The Journal Of Immunology 2021, 207: 950-965. PMID: 34282002, PMCID: PMC8324558, DOI: 10.4049/jimmunol.2100162.Peer-Reviewed Original ResearchConceptsActin regulating proteinsDevelopmental stagesNK cellsCell developmental stagesHuman hematopoietic precursorsActin homeostasisPeripheral bloodSignaling interactionsHuman NK cell populationsMolecular networksExpression profilesDifferential expressionNK cell populationVaried microenvironmentsInnate immune cellsRegulating proteinsVariety of microenvironmentsHematopoietic precursorsAdhesomeActin contentCell coculture systemCell populationsImmune cellsExpressionProteinSignature of Enhanced Effector Function Defines Early Life Regulatory T Cells
Connors T, Bradley M, Verma S, Waldman E, Jang M, Grunstein E, Maurrasse S, Pethe K, Dogra P, Farber D. Signature of Enhanced Effector Function Defines Early Life Regulatory T Cells. The Journal Of Immunology 2021, 206: 98.27-98.27. DOI: 10.4049/jimmunol.206.supp.98.27.Peer-Reviewed Original ResearchRegulatory T cellsT cellsImmune responseEarly lifeGut-specific homingPrimary antigenic challengeIntestinal immune homeostasisConventional T cellsPotential effector mechanismsInflammatory immune responseEnhanced effector functionMulti-parameter flow cytometryAdult TregsImmunosuppressive mechanismsAntigenic challengeImmune homeostasisEffector mechanismsTregsImmune developmentEffector functionsSuppressive functionImmunological challengeHigh proliferative capacityCell cycleBulk RNA sequencingDirect Laryngoscopy and Bronchoscopy: Purpose & Setup
Maurrasse S, Moushey A, Valika T, Waldman E. Direct Laryngoscopy and Bronchoscopy: Purpose & Setup. CSurgeries 2021 DOI: 10.17797/2021030301.Peer-Reviewed Original ResearchMyringotomy and Tympanostomy Tube (Ear Tube) Placement
Maurrasse S, Waldman E. Myringotomy and Tympanostomy Tube (Ear Tube) Placement. CSurgeries 2021 DOI: 10.17797/2021030302.Peer-Reviewed Original ResearchDirect Laryngoscopy and Bronchoscopy: Performing a Diagnostic Exam
Maurrasse S, Moushey A, Valika T, Waldman E. Direct Laryngoscopy and Bronchoscopy: Performing a Diagnostic Exam. CSurgeries 2021 DOI: 10.17797/2021033101.Peer-Reviewed Original Research
2020
Ethical and Public Health Implications of Targeted Screening for Congenital Cytomegalovirus
Gievers LL, Holmes AV, Loyal J, Larson IA, Oliveira CR, Waldman EH, Khaki S. Ethical and Public Health Implications of Targeted Screening for Congenital Cytomegalovirus. Pediatrics 2020, 146: e20200617. PMID: 32591436, PMCID: PMC8171256, DOI: 10.1542/peds.2020-0617.Commentaries, Editorials and LettersConceptsCongenital cytomegalovirusMajority of newbornsNewborn hearing screenHearing screenHearing lossDevelopmental delayCommon congenital infectionHigh-risk groupSensorineural hearing lossPublic health implicationsHealth care systemCongenital infectionCCMV infectionClinical presentationClinical symptomsOngoing surveillanceClinical heterogeneityTargeted screeningNewbornsVisual impairmentEarly detectionCare systemScreening approachHealth implicationsCytomegalovirusIn‐Office Tympanostomy Tube Placement in Children Using Iontophoresis and Automated Tube Delivery
Lustig LR, Ingram A, Vidrine DM, Gould AR, Zeiders JW, Ow RA, Thompson CR, Moss JR, Mehta R, McClay JE, Brenski A, Gavin J, Waldman EH, Ansley J, Yen DM, Chadha NK, Murray MT, Kozak FK, York C, Brown DM, Grunstein E, Sprecher RC, Sherman DA, Schoem SR, Puchalski R, Hills S, Calzada A, Harfe D, England LJ, Syms CA. In‐Office Tympanostomy Tube Placement in Children Using Iontophoresis and Automated Tube Delivery. The Laryngoscope 2020, 130: s1-s9. PMID: 32160320, PMCID: PMC7187287, DOI: 10.1002/lary.28612.Peer-Reviewed Original ResearchConceptsTympanostomy tube placementTube placementPivotal cohortAdverse eventsTechnical successChildren 5Mean FPS-R scoresIndividual cohort studiesSerious adverse eventsNonserious adverse eventsProspective multicenter studyYears of ageLead-InChildren ages 6Lidocaine iontophoresisMinutes postprocedureCohort studyPatients 5Epinephrine iontophoresisMulticenter studyLocal anesthesiaMean agePapoose boardTube deliveryAge groupsEarly experience with feasibility of balloon sinus dilation in complicated pediatric acute frontal rhinosinusitis
Maurrasse SK, Hwa TP, Waldman E, Kacker A, Pearlman AN. Early experience with feasibility of balloon sinus dilation in complicated pediatric acute frontal rhinosinusitis. Laryngoscope Investigative Otolaryngology 2020, 5: 194-199. PMID: 32337348, PMCID: PMC7178448, DOI: 10.1002/lio2.359.Peer-Reviewed Original ResearchAcute frontal sinusitisChronic frontal sinusitisFrontal sinusitisRecurrent diseasePediatric populationComplicated acute rhinosinusitisProper clinical settingEndoscopic sinus surgeryBalloon sinus dilationSafety of balloonRegional complicationsAcute rhinosinusitisIntracranial manifestationsPediatric patientsSurgical interventionFrontal rhinosinusitisSinus surgeryIntraorbital complicationsSinus dilationBalloon sinuplastyUncommon problemSinusitisClinical settingPrior efficacyRhinosinusitisPediatric thyroidectomies: A surgical subspecialty comparison
Savoca E, Torabi SJ, Kasle D, Mets E, Hajek M, Waldman EH. Pediatric thyroidectomies: A surgical subspecialty comparison. International Journal Of Pediatric Otorhinolaryngology 2020, 132: 109945. PMID: 32070842, DOI: 10.1016/j.ijporl.2020.109945.Peer-Reviewed Original ResearchConceptsPediatric general surgeryShorter operative timePediatric general surgeonsMedical adverse eventsAdverse eventsGeneral surgeryOperative timeGeneral surgeonsNational Surgical Quality Improvement Program-Pediatric dataSurgical complication rateSurgical adverse eventsSub-group analysisGeneral surgery groupComplication differencesOtolaryngology groupPediatric thyroidectomyPerioperative courseSurgery groupComplication ratePatient characteristicsPediatric patientsPediatric populationAdverse outcomesSafe procedureUnivariate analysis
2019
Tick Attached to the Tympanic Membrane
Kasle D, Waldman E. Tick Attached to the Tympanic Membrane. New England Journal Of Medicine 2019, 380: 1761-1761. PMID: 31042828, DOI: 10.1056/nejmicm1812049.Peer-Reviewed Original Research
2018
A case of pediatric cervicofacial actinomyces masquerading as malignancy: Case report and review of the literature
Savoca E, Mehra S, Waldman EH. A case of pediatric cervicofacial actinomyces masquerading as malignancy: Case report and review of the literature. International Journal Of Pediatric Otorhinolaryngology 2018, 116: 204-208. PMID: 30554700, DOI: 10.1016/j.ijporl.2018.11.001.Peer-Reviewed Original ResearchConceptsAnterior neck massProlonged antibiotic courseFine needle aspiratesSix-week courseAntibiotic coursesOral penicillinSurgical debridementParenteral penicillinUncommon infectionMalignant appearanceNeck massOpen biopsyCase reportNeedle biopsyCulture sensitivityNeedle aspiratesBiopsyConvalescent therapyActinomycesDiagnosisPenicillinCase discussionDebridementPatientsMalignancy
2017
An unusual presentation of a rare soft tissue tumor in the tongue: Inflammatory myofibroblastic tumor.
Dodhia S, Merea VS, Hibshoosh H, Nedumcheril M, Gudis DA, Rahmati R, Waldman EH. International Journal of Pediatric Otorhinolaryngology Extra 15 (2017) 1-3Peer-Reviewed Original ResearchAn unusual presentation of a rare soft tissue tumor in the tongue: Inflammatory myofibroblastic tumor
Dodhia S, Merea V, Hibshoosh H, Nedumcheril M, Gudis D, Rahmati R, Waldman E. An unusual presentation of a rare soft tissue tumor in the tongue: Inflammatory myofibroblastic tumor. International Journal Of Pediatric Otorhinolaryngology Case Reports 2017, 15: 1-3. DOI: 10.1016/j.pedex.2016.11.003.Peer-Reviewed Original ResearchInflammatory myofibroblastic tumorMyofibroblastic tumorPediatric patientsTongue lesionsUnusual presentationRare soft tissue neoplasmRare soft tissue tumorSoft tissue tumorsIntermediate biologic potentialSoft tissue neoplasmOral tongueAtypical presentationDifferential diagnosisTissue tumorsMalignant processBiologic potentialLiterature suggestiveTumorsPatientsLesionsPresentationTongueNeoplasmsDiagnosis
2016
A population based analysis of the implementation of pediatric facemasks in girls youth lacrosse
Walls A, Kasle D, Aaronson N, Harley E, Waldman E. A population based analysis of the implementation of pediatric facemasks in girls youth lacrosse. International Journal Of Pediatric Otorhinolaryngology 2016, 93: 141-144. PMID: 28109486, DOI: 10.1016/j.ijporl.2016.12.040.Peer-Reviewed Original ResearchConceptsAbsolute risk reductionRelative riskEar injuryLacrosse injuriesTotal incidenceFacial lacerationsRisk reductionRelative risk reductionSignificant decreaseCross-sectional reviewAdditional protective equipmentFacial abrasionsEmergency roomFacial fracturesFacial injuriesFacemask useNeck regionInjuryLacerationProtective equipmentIncidenceNational databaseSectional reviewFemale athletesFurther risk
2014
CPAS: Surgical approach with combined sublabial bone resection and inferior turbinate reduction without stents
Merea V, Lee AH, Peron DL, Waldman EH, Grunstein E. CPAS: Surgical approach with combined sublabial bone resection and inferior turbinate reduction without stents. The Laryngoscope 2014, 125: 1460-1464. PMID: 25475763, DOI: 10.1002/lary.25001.Peer-Reviewed Original ResearchConceptsInferior turbinate reductionUse of stentsSymptomatic improvementTurbinate reductionRetrospective chart reviewCPA patientsNasal scarringAirway obstructionAperture stenosisChart reviewConsecutive patientsNasal obstructionPatent airwaySurgical managementSurgical approachMedical recordsSurgical correctionBone resectionInferior turbinateStent useCongenital narrowingSublabial approachAlar necrosisNasal stentsPatients
2013
Factors contributing to cost in partial versus total tonsillectomy
Stucken EZ, Grunstein E, Haddad J, Modi VK, Waldman EH, Ward RF, Stewart MG, April MM. Factors contributing to cost in partial versus total tonsillectomy. The Laryngoscope 2013, 123: 2868-2872. PMID: 23529896, DOI: 10.1002/lary.24025.Peer-Reviewed Original ResearchConceptsTotal tonsillectomyPartial intracapsular tonsillectomyPartial tonsillectomyRetrospective reviewIntracapsular tonsillectomyPediatric intensive care unit stayUniversity-based tertiary care hospitalIntensive care unit stayPostoperative emergency room visitsPostanesthesia care unit timeEmergency department visitsNumber of readmissionsTertiary care hospitalEmergency room visitsNumber of patientsPostoperative admissionUnit stayObstructive symptomsPostoperative hemorrhageCare hospitalDepartment visitsPediatric patientsOperative timePostoperative managementPACU time
2010
Not a "sound" decision: is cochlear implantation always the best choice?
O'Brien LC, Kenna M, Neault M, Clark TA, Kammerer B, Johnston J, Waldman E, Thomas SP, Forbes P, Licameli GR. Not a "sound" decision: is cochlear implantation always the best choice? International Journal Of Pediatric Otorhinolaryngology 2010, 74: 1144-8. PMID: 20692711, DOI: 10.1016/j.ijporl.2010.07.002.Peer-Reviewed Original Research
2009
Controversies in Pediatric Cochlear Implantation
On Audio-Digest Otolaryngology CD Volume 42, Issue 03; February 2009, Observations in Assisted HearingPeer-Reviewed Original Research