Emily Sutton, PhD
Postdoctoral FellowAbout
Research
Publications
2022
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives
Pigg H, Yglesias M, Sutton E, McDevitt C, Shaw M, DeRose V. Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives. ACS Chemical Biology 2022, 17: 2262-2271. PMID: 35917257, DOI: 10.1021/acschembio.2c00399.Peer-Reviewed Original ResearchConceptsNucleolar stressStress inductionHigh overall degreeSpecific cellular responsesRibosome biogenesisRRNA transcriptionConformation showCellular responsesCell deathDNA damageKey intermolecular interactionsH drug treatmentMechanistic understandingCellular accumulationSmall moleculesDNA adduct formationInductionBiogenesisTranscriptionStressInhibitionAdduct formationInteractionPotential explanationConformation
2021
Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin
Sutton EC, DeRose VJ. Early nucleolar responses differentiate mechanisms of cell death induced by oxaliplatin and cisplatin. Journal Of Biological Chemistry 2021, 296: 100633. PMID: 33819479, PMCID: PMC8131322, DOI: 10.1016/j.jbc.2021.100633.Peer-Reviewed Original Research
2019
Tracking the cellular targets of platinum anticancer drugs: Current tools and emergent methods
Sutton E, McDevitt C, Yglesias M, Cunningham R, DeRose V. Tracking the cellular targets of platinum anticancer drugs: Current tools and emergent methods. Inorganica Chimica Acta 2019, 498: 118984. DOI: 10.1016/j.ica.2019.118984.Peer-Reviewed Original ResearchNucleolar Stress Induction by Oxaliplatin and Derivatives
Sutton EC, McDevitt CE, Prochnau JY, Yglesias MV, Mroz AM, Yang MC, Cunningham RM, Hendon CH, DeRose VJ. Nucleolar Stress Induction by Oxaliplatin and Derivatives. Journal Of The American Chemical Society 2019, 141: 18411-18415. PMID: 31670961, PMCID: PMC7735645, DOI: 10.1021/jacs.9b10319.Peer-Reviewed Original ResearchMonofunctional platinum(II) compounds and nucleolar stress: is phenanthriplatin unique?
McDevitt CE, Yglesias MV, Mroz AM, Sutton EC, Yang MC, Hendon CH, DeRose VJ. Monofunctional platinum(II) compounds and nucleolar stress: is phenanthriplatin unique? JBIC Journal Of Biological Inorganic Chemistry 2019, 24: 899-908. PMID: 31494760, PMCID: PMC7660985, DOI: 10.1007/s00775-019-01707-9.Peer-Reviewed Original Research