2024
Prognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010)
Wang E, Misra S, Yan J, Chook P, Kawamura Y, Kitagawa R, Kim J, Gilmore E, De Havenon A, Sivaraju A, Hirsch L, Falcone G, Sansing L, Magid-Bernstein J, Mishra N. Prognostication of Outcomes in Stroke Patients Using Inflammatory Biomarkers: Findings from the Yale Post-stroke Epilepsy Research Group (P3-5.010). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204783.Peer-Reviewed Original Research
2023
Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study
Prasad A, Gilmore E, Kim J, Begunova L, Olexa M, Beekman R, Falcone G, Matouk C, Ortega-Gutierrez S, Temkin N, Barber J, Diaz-Arrastia R, de Havenon A, Petersen N. Impact of Therapeutic Interventions on Cerebral Autoregulatory Function Following Severe Traumatic Brain Injury: A Secondary Analysis of the BOOST-II Study. Neurocritical Care 2023, 41: 91-99. PMID: 38158481, PMCID: PMC11285118, DOI: 10.1007/s12028-023-01896-x.Peer-Reviewed Original ResearchCerebral perfusion pressureBrain tissue hypoxiaSevere traumatic brain injuryTissue hypoxiaTraumatic brain injuryBlood pressureCerebral hypoperfusionBrain injuryAutoregulatory functionMean cerebral perfusion pressureSecondary analysisOptimal cerebral perfusion pressurePercent timeCerebral autoregulatory functionLimits of autoregulationPhase II trialArterial blood pressureBrain tissue oxygenIntracranial pressure monitoringCPP augmentationHemodynamic augmentationAutoregulatory indexII trialBP managementPerfusion pressureEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2021
Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349)
Mazurek M, Yuen M, Cahn B, Rosen M, Gobeske K, Gilmore E, Hwang D, Kaddouh F, Kim J, Falcone G, Petersen N, Siner J, Spudich S, Sze G, Kimberly W, Sheth K. Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1349.Peer-Reviewed Original Research
2020
Portable, Bedside, Low-field Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage (270)
Shah J, Cahn B, By S, Welch E, Sacolick L, Yuen M, Mazurek M, Wira C, Leasure A, Matouk C, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Sze G, Rosen M, Kimberly W, Sheth K. Portable, Bedside, Low-field Magnetic Resonance Imaging in an Intensive Care Setting for Intracranial Hemorrhage (270). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.270.Peer-Reviewed Original ResearchDeployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272)
Cahn B, Shah J, Dyvorne H, O’Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Deployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.272.Peer-Reviewed Original Research
2019
Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.Peer-Reviewed Original ResearchConceptsLimits of autoregulationAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageFunctional outcomeArterial pressureIntracranial pressureBP targetsWorse outcomesPercent timeBlood pressure targetsBlood pressure managementMean arterial pressureModified Rankin ScalePotential neuroprotective strategiesWorse functional outcomePoor functional outcomeCerebral blood flowMultivariate logistic regressionTotal monitoring periodAutoregulatory indexPressure targetsCerebral ischemiaNeuroprotective strategiesRankin ScaleCerebral autoregulationDeviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.Peer-Reviewed Original ResearchEarly Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation
Witsch J, Kuohn L, Hebert R, Cord B, Sansing L, Gilmore EJ, Hwang DY, Petersen N, Falcone GJ, Matouk C, Sheth KN. Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation. Journal Of Stroke And Cerebrovascular Diseases 2019, 28: 104280. PMID: 31326270, DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.038.Peer-Reviewed Original ResearchConceptsSpontaneous subarachnoid hemorrhageModified Rankin ScaleLong-term outcomesSubarachnoid hemorrhageUnfavorable outcomePercent of patientsExclusion of patientsStratification of patientsScore variablesAneurysmal etiologyBleeding sourceRankin ScaleFunctional outcomeMean ageEarly prognosticationPrognostication scoresStudy investigatorsHospital resourcesPatientsDisability partAneurysm coilingOutcomesHigh gradeCharacteristic curveHemorrhageDecreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome
Petersen NH, Ortega-Gutierrez S, Wang A, Lopez GV, Strander S, Kodali S, Silverman A, Zheng-Lin B, Dandapat S, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Amin H, Cord B, Hebert RM, Matouk C, Sheth KN. Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome. Stroke 2019, 50: 1797-1804. PMID: 31159701, PMCID: PMC6787912, DOI: 10.1161/strokeaha.118.024286.Peer-Reviewed Original ResearchConceptsFinal infarct volumeWorse functional outcomeInfarct volumeEndovascular thrombectomyFunctional outcomeOcclusion strokeCerebral infarction 2b/3 reperfusionPressure reductionLarge vessel intracranial occlusionsGreater infarct growthBlood pressure reductionComprehensive stroke centerPercent of patientsBlood pressure managementLarger infarct volumesModified Rankin ScaleRankin Scale scoreMultivariable logistic regressionRelative hypotensionSustained hypotensionInfarct progressionNinety patientsInfarct growthIschemic penumbraIschemic stroke
2018
History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics
Sommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.Peer-Reviewed Original ResearchSafety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033)
Chu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Cord B, Samarth G, Petersen N, Gilmore E, Schindler J, Matouk C, Sheth K, Falcone G. Safety Outcomes of Thrombolysis for Acute Ischemic Stroke in Patients with History of Intracranial Hemorrhage (P4.033). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.033.Peer-Reviewed Original ResearchPlasma IL-6 Levels are Independently Associated with Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage (P4.296)
Leasure A, Steinschneider A, Falcone G, Gilmore E, Sansing L, Sheth K. Plasma IL-6 Levels are Independently Associated with Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage (P4.296). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.296.Peer-Reviewed Original Research