2025
Later midline shift is associated with better post-hospitalization discharge status after large middle cerebral artery stroke
Song J, Stafford R, Pohlmann J, Kim I, Cheekati M, Dennison S, Brush B, Chatzidakis S, Huang Q, Smirnakis S, Gilmore E, Mohammed S, Abdalkader M, Benjamin E, Dupuis J, Greer D, Ong C. Later midline shift is associated with better post-hospitalization discharge status after large middle cerebral artery stroke. Scientific Reports 2025, 15: 11738. PMID: 40188256, PMCID: PMC11972405, DOI: 10.1038/s41598-025-95954-3.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryPeak edemaMiddle cerebral artery strokeMidline shiftCerebral edemaDecompressive hemicraniectomyRetrospective study of patientsMiddle cerebral artery territory infarctionStudy of patientsDischarge statusFavorable discharge statusAssociated with higher oddsRetrospective studyTerritory infarctionCerebral arteryEdemaTreatment decisionsPatientsIschemic strokeHigher oddsMultivariate modelArtery strokeUnfavorable dischargeTwo-centerPrevalence and prognostic impact of ST-segment elevation in lead aVR among patients with cardiac arrest
Banna S, Schenck C, Kim N, Ali T, Gilmore E, Greer D, Beekman R, Miller P. Prevalence and prognostic impact of ST-segment elevation in lead aVR among patients with cardiac arrest. European Heart Journal Acute Cardiovascular Care 2025, 14: 232-236. PMID: 39873390, DOI: 10.1093/ehjacc/zuaf018.Peer-Reviewed Original ResearchOut-of-hospital cardiac arrestAssociated with higher in-hospital mortalityHigher in-hospital mortalityST-segment elevationIn-hospital mortalityReturn of spontaneous circulationCardiac arrestShockable rhythmLead aVRPoor neurological outcomeAcute coronary syndromeMultivariate logistic regressionPrognostic impactPost-ROSCPrognostic significanceSpontaneous circulationCA patientsNeurological outcomeCoronary syndromeIdentified patientsMultivariable adjustmentMain diseasePatientsCA survivorsArrest characteristicsQuantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke
Du Y, Pohlmann J, Chatzidakis S, Brush B, Malinger L, Stafford R, Cervantes‐Arslanian A, Benjamin E, Gilmore E, Dupuis J, Greer D, Smirnakis S, Mohammed S, Ong C. Quantitative Pupillometry Predicts Neurologic Deterioration in Patients with Large Middle Cerebral Artery Stroke. Annals Of Neurology 2025, 97: 930-941. PMID: 39825740, PMCID: PMC12011534, DOI: 10.1002/ana.27178.Peer-Reviewed Original ResearchNeurological Pupil indexMiddle cerebral arteryQuantitative pupillometryNeurological deteriorationMiddle cerebral artery strokeDilation velocitySingle-center observational cohort studyAlberta Stroke Program Early CT ScoreCox proportional hazards modelsObservational cohort studyIntensive care unitProportional hazards modelCT scoreCohort studyYouden indexCerebral arteryCare unitHazards modelTukey testLinear mixed-effects modelsPatientsArtery strokeDilatationOptimal thresholdMixed-effects models
2024
Accuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator
Sheikh Z, Dhakar M, Fong M, Fang W, Ayub N, Molino J, Haider H, Foreman B, Gilmore E, Mizrahi M, Karakis I, Schmitt S, Osman G, Yoo J, Hirsch L. Accuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator. Neurology 2024, 104: e210234. PMID: 39724534, DOI: 10.1212/wnl.0000000000210234.Peer-Reviewed Original ResearchConceptsElectrographic status epilepticusNegative predictive valueStatus epilepticusTreat nonconvulsive status epilepticusPredictive valueCo-primary outcome measuresNonconvulsive status epilepticusPositive predictive valueRetrospective observational studyClass II evidenceLow-to-moderate sensitivityLimited-resource settingsII evidenceTriage patientsObservational studyPatientsRegional hospitalOutcome measuresExpert reviewEpilepticusScreening toolCommunity hospitalBurden estimatesEEGPPVComparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis
Woodward M, Kardon A, Manners J, Schleicher S, Pergakis M, Ciryam P, Podell J, Denney Zimmerman W, Galvagno S, Butt B, Pritchard J, Parikh G, Gilmore E, Badjatia N, Morris N. Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis. Epilepsy & Behavior Reports 2024, 25: 100645. PMID: 38299124, PMCID: PMC10827579, DOI: 10.1016/j.ebr.2024.100645.Peer-Reviewed Original ResearchRefractory status epilepticusNeurocritical care unitEtomidate inductionStatus epilepticusSingle-center retrospective analysisSingle-center retrospective reviewRapid sequence intubationHospital intubationPrimary endpointSeizure cessationAnesthetic medicationsCare unitElectrographic seizuresRetrospective reviewEndotracheal intubationSequence intubationInduction agentRetrospective analysisIntubationHigh incidencePatientsLogistic regressionSeizuresEnriched populationEpilepticus
2023
Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society
Hirsch K, Abella B, Amorim E, Bader M, Barletta J, Berg K, Callaway C, Friberg H, Gilmore E, Greer D, Kern K, Livesay S, May T, Neumar R, Nolan J, Oddo M, Peberdy M, Poloyac S, Seder D, Taccone F, Uzendu A, Walsh B, Zimmerman J, Geocadin R. Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society. Neurocritical Care 2023, 40: 1-37. PMID: 38040992, PMCID: PMC10861627, DOI: 10.1007/s12028-023-01871-6.Peer-Reviewed Original ResearchCritical care managementCardiac arrestNeurocritical Care SocietyCare managementClinical studiesAmerican Heart Association Emergency Cardiovascular Care CommitteeHigh-quality clinical studiesExpert panel consensus statementHigh-certainty evidencePractice guideline recommendationsLow-certainty evidenceAmerican Heart AssociationExpert consensus panelHigh-quality studiesMultiple medical specialtiesGuideline recommendationsHeart AssociationAbsence of guidelinesConsensus statementPractice guidelinesConsensus panelCare CommitteePatientsAreas of uncertaintyOrgan systemsCritical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society
Hirsch K, Abella B, Amorim E, Bader M, Barletta J, Berg K, Callaway C, Friberg H, Gilmore E, Greer D, Kern K, Livesay S, May T, Neumar R, Nolan J, Oddo M, Peberdy M, Poloyac S, Seder D, Taccone F, Uzendu A, Walsh B, Zimmerman J, Geocadin R, Society O. Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society. Circulation 2023, 149: e168-e200. PMID: 38014539, PMCID: PMC10775969, DOI: 10.1161/cir.0000000000001163.Peer-Reviewed Original ResearchConceptsCritical care managementCardiac arrestNeurocritical Care SocietyCare managementClinical studiesAmerican Heart Association Emergency Cardiovascular Care CommitteeHigh-quality clinical studiesExpert panel consensus statementHigh-certainty evidencePractice guideline recommendationsLow-certainty evidenceAmerican Heart AssociationExpert consensus panelHigh-quality studiesMultiple medical specialtiesGuideline recommendationsHeart AssociationAbsence of guidelinesConsensus statementPractice guidelinesConsensus panelCare CommitteePatientsAreas of uncertaintyOrgan systemsValidation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest
Kim N, Kitlen E, Garcia G, Khosla A, Miller P, Johnson J, Wira C, Greer D, Gilmore E, Beekman R. Validation of the rCAST score and comparison to the PCAC and FOUR scores for prognostication after out-of-hospital cardiac arrest. Resuscitation 2023, 188: 109832. PMID: 37178901, DOI: 10.1016/j.resuscitation.2023.109832.Peer-Reviewed Original ResearchConceptsPoor neurologic outcomeUnited States cohortHospital cardiac arrestOHCA patientsNeurologic outcomeCardiac arrestPost-cardiac arrest syndromePoor neurological outcomeScore predictive abilityHospital mortalityNeurological outcomeUnResponsiveness (FOUR) scorePoor outcomeRetrospective studyAccurate outcome predictionPrognostic performanceFull OutlineDeLong testOutcome predictionPatientsMortalityOutcomesScoresCohortPredictive abilityDiscrepancies Between Neuroprognostication Assessments and End-of-Life Decision-Making in Post-Cardiac Arrest Patients (S4.002)
Rubenstein A, Stafford R, Scott A, Maciel C, Silva G, Beekman R, Gilmore E, Greer D. Discrepancies Between Neuroprognostication Assessments and End-of-Life Decision-Making in Post-Cardiac Arrest Patients (S4.002). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203933.Peer-Reviewed Original Research
2022
Cerebral hypoperfusion after nimodipine administration is associated with worse functional outcomes in subarachnoid hemorrhage patients (P6-7.001)
Bartolome D, Begunova Y, Prasad A, Soto A, Kobsa J, Top I, Quispe-Orozco D, Farooqui M, Zevallos C, Kim J, Gilmore E, Beekman R, De Havenon A, Matouk C, Sheth K, Ortega-Gutiérrez S, Petersen N. Cerebral hypoperfusion after nimodipine administration is associated with worse functional outcomes in subarachnoid hemorrhage patients (P6-7.001). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3609.Peer-Reviewed Original Research
2021
The Significance of LRDA With Bilateral Involvement Compared With GRDA on EEG in Critically Ill Patients
Fong M, Jadav R, Alzawahmah M, Hussein O, Gilmore E, Hirsch L. The Significance of LRDA With Bilateral Involvement Compared With GRDA on EEG in Critically Ill Patients. Journal Of Clinical Neurophysiology 2021, 40: 434-442. PMID: 37399042, DOI: 10.1097/wnp.0000000000000897.Peer-Reviewed Original ResearchConceptsLateralized rhythmic delta activityGroup of patientsRhythmic delta activityFocal abnormalitiesDelta activitySporadic epileptiform dischargesCritically Ill PatientsFocal electrographic seizuresComputed tomography scanClear etiologyIschemic strokeBilateral involvementIll patientsMetabolic encephalopathiesElectrographic seizuresImaging findingsFocal slowingCortical excitabilitySubdural hemorrhageTomography scanEpileptiform dischargesPatientsControl groupSeizuresContinuous EEGLow-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349)
Mazurek M, Yuen M, Cahn B, Rosen M, Gobeske K, Gilmore E, Hwang D, Kaddouh F, Kim J, Falcone G, Petersen N, Siner J, Spudich S, Sze G, Kimberly W, Sheth K. Low-Field, Portable Magnetic Resonance Imaging at the Bedside to Assess Brain Injury in Patients with Severe COVID-19 (1349). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.1349.Peer-Reviewed Original Research
2020
Risk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457)
Nguyen C, Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Peshwe K, de Havenon A, Gilmore E, Sansing L, Schindler J, Matouk C, Sheth K, Petersen N. Risk of Worse Outcome in Stroke Patients with High Blood Pressure Variability After Endovascular Thrombectomy May Be Amplified by Impaired Cerebral Autoregulation (4457). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.4457.Peer-Reviewed Original ResearchDeployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272)
Cahn B, Shah J, Dyvorne H, O’Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Deployment of Portable, Bedside, Low-field Magnetic Resonance Imaging for Evaluation of Stroke Patients (272). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.272.Peer-Reviewed Original Research
2019
Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation
Witsch J, Kuohn L, Hebert R, Cord B, Sansing L, Gilmore EJ, Hwang DY, Petersen N, Falcone GJ, Matouk C, Sheth KN. Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation. Journal Of Stroke And Cerebrovascular Diseases 2019, 28: 104280. PMID: 31326270, DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.038.Peer-Reviewed Original ResearchConceptsSpontaneous subarachnoid hemorrhageModified Rankin ScaleLong-term outcomesSubarachnoid hemorrhageUnfavorable outcomePercent of patientsExclusion of patientsStratification of patientsScore variablesAneurysmal etiologyBleeding sourceRankin ScaleFunctional outcomeMean ageEarly prognosticationPrognostication scoresStudy investigatorsHospital resourcesPatientsDisability partAneurysm coilingOutcomesHigh gradeCharacteristic curveHemorrhageComparison of machine learning models for seizure prediction in hospitalized patients
Struck AF, Rodriguez‐Ruiz A, Osman G, Gilmore EJ, Haider HA, Dhakar MB, Schrettner M, Lee JW, Gaspard N, Hirsch LJ, Westover MB, Consortium C. Comparison of machine learning models for seizure prediction in hospitalized patients. Annals Of Clinical And Translational Neurology 2019, 6: 1239-1247. PMID: 31353866, PMCID: PMC6649418, DOI: 10.1002/acn3.50817.Peer-Reviewed Original ResearchConceptsLow-risk patientsNegative predictive valueEvaluation cohortContinuous EEGElastic net logistic regressionMulticenter databaseRisk stratificationSeizure riskPatientsPredictive valueComparable AUCSecondary analysisLogistic regressionCohortFirst hourSeizure predictionEEG recordingsEEGRisk calibrationLarge proportionSeizuresComplex neural networksDynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025)
Silverman A, Wang A, Kodali S, Strander S, Cord B, Hebert R, Matouk C, Sheth K, Gilmore E, Petersen N. Dynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.3-025.Peer-Reviewed Original ResearchBlood Pressure Management Outside Individualized Limits of Autoregulation is Associated with Neurologic Deterioration and Worse Functional Outcomes in Patients with Large-Vessel Occlusion (LVO) Ischemic Stroke (S52.002)
Silverman A, Wang A, Strander S, Kodali S, Sansing L, Schindler J, Gilmore E, Sheth K, Petersen N. Blood Pressure Management Outside Individualized Limits of Autoregulation is Associated with Neurologic Deterioration and Worse Functional Outcomes in Patients with Large-Vessel Occlusion (LVO) Ischemic Stroke (S52.002). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.s52.002.Peer-Reviewed Original Research
2018
History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics
Sommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.Peer-Reviewed Original ResearchF80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage
Sheikh Z, Stretz C, Maciel C, Dhakar M, Hirsch L, Gilmore E. F80. Seizures and hyperexcitable EEG patterns in spontaneous deep intraparenchymal hemorrhage. Clinical Neurophysiology 2018, 129: e96-e97. DOI: 10.1016/j.clinph.2018.04.243.Peer-Reviewed Original ResearchDeep intraparenchymal hemorrhageAnti-seizure drugsDecompressive hemicraniectomyIntraparenchymal hemorrhageThalamic involvementHematoma volumeContinuous EEGClinical seizuresSedative infusionsSurgical interventionInsular involvementPrior historyHigh riskMean hematoma volumeIncidence of seizuresRisk of seizuresRhythmic delta activitySpike-wave dischargesHigher hematoma volumeRetrospective reviewElectrographic seizuresSubdural hemorrhageHead CTHigh incidencePatients
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply