2019
Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis
Won C, Reid M, Sofer T, Azarbarzin A, Purcell S, White D, Wellman A, Sands S, Redline S. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis. Sleep 2019, 43: zsz274. PMID: 31687772, PMCID: PMC7215264, DOI: 10.1093/sleep/zsz274.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaMulti-Ethnic StudyArousal criteriaObstructive sleep apnea phenotypesSex differencesLow arousal thresholdRelative sex differencesApnea phenotypesNREM-AHIPathophysiological endotypesREM-OSAAirway collapsibilityOSA prevalenceSleep apneaDesaturation criteriaEndotypesSex disparitiesArousal thresholdPolysomnography dataSignificant sex differencesREM eventsWomenLow loop gainNREM
2018
Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.
Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHypopnea definitionsDesaturation criteriaOdds ratioCardiovascular diseaseOSA diagnosisSeverity of OSAModerate obstructive sleep apneaSevere obstructive sleep apneaDifferent hypopnea definitionsLess smoking historySleep-disordered breathingIschemic heart diseaseSignificant risk factorsCross-sectional analysisArousal definitionHypopnea criteriaCardiovascular riskOSA severitySmoking historyHeart failureClinical featuresSleep apneaOSA groupRisk factors