2025
Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients.
Chen H, Colasurdo M, Matsukawa H, Cunningham C, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Grandhi R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Chowdhry S, Altschul D, Spiotta A, Kan P. Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients. Interventional Neuroradiology 2025, 15910199251343283. PMID: 40530425, PMCID: PMC12176791, DOI: 10.1177/15910199251343283.Peer-Reviewed Original ResearchLow Alberta Stroke Program Early CT ScoreAlberta Stroke Program Early CT ScoreEffect of endovascular thrombectomyM2 occlusionsIntracranial hemorrhageM2 patientsAssociated with intracranial hemorrhageOdds of all-cause mortalityMulticenter retrospective studyOdds of poor outcomeMultivariate logistic regression modelAll-cause mortalityMiddle cerebral arteryStroke patientsM1 patientsM1 occlusionCT scoreRetrospective studyLogistic regression modelsPoor outcomeMultivariable adjustmentPrimary outcomeCerebral arteryTreatment outcomesEndovascular thrombectomyMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, 17: e206-e215. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatients
2024
Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohort
2023
Outcomes of mechanical thrombectomy in stroke patients with extreme large infarction core
Almallouhi E, Zandpazandi S, Anadani M, Cunningham C, Sowlat M, Matsukawa H, Orscelik A, Elawady S, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Grossberg J, Alawieh A, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Dumont T, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A. Outcomes of mechanical thrombectomy in stroke patients with extreme large infarction core. Journal Of NeuroInterventional Surgery 2023, 16: 1268-1274. PMID: 38041671, DOI: 10.1136/jnis-2023-021046.Peer-Reviewed Original ResearchConceptsLarge vessel occlusionIntracranial internal carotid arteryMechanical thrombectomyInfarct coreFavorable outcomeAlberta Stroke Program Early CT ScoreAssociated with favorable outcomesIntravenous tissue plasminogen activatorOutcomes of mechanical thrombectomyRetrospective cohort studyGroup of patientsNational Institutes of Health Stroke ScaleInternal carotid arteryLarge vessel occlusion patientsTissue plasminogen activatorOutcomes of MTMiddle cerebral arteryYears of ageHealth Stroke ScaleMRS 0Median ageCT scoreModified ThrombolysisAspiration thrombectomyCohort studyComprehensive analysis of the impact of procedure time and the ‘golden hour’ in subpopulations of stroke thrombectomy patients
Ash M, Dimisko L, Chalhoub R, Howard B, Cawley C, Matouk C, Pabaney A, Spiotta A, Jabbour P, Maier I, Wolfe S, T A, Kim J, Psychogios M, Mascitelli J, Starke R, Shaban A, Yoshimura S, De Leacy R, Kan P, Fragata I, Polifka A, Arthur A, Park M, Crosa R, Williamson R, Dumont T, Levitt M, Al Kasab S, Tjoumakaris S, Liman J, Saad H, Samaniego E, Fargen K, Grossberg J, Alawieh A. Comprehensive analysis of the impact of procedure time and the ‘golden hour’ in subpopulations of stroke thrombectomy patients. Journal Of NeuroInterventional Surgery 2023, 16: 1069-1075. PMID: 37875342, DOI: 10.1136/jnis-2023-020792.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageSubpopulation of patientsProcedure timePosterior circulation strokeModified Rankin ScaleTissue plasminogen activatorEndovascular thrombectomyCirculation strokePoor outcomeGroin puncture to successful recanalizationAlberta Stroke Program Early CT ScoreAssociated with worse clinical outcomesRate of symptomatic intracranial hemorrhageIV tissue plasminogen activatorSymptomatic intracranial hemorrhage rateEffects of procedure timeIV tPA treatmentAge groupsOnset-to-groin timeAssociated with higher oddsAcute ischemic strokeCT scoreIntracranial hemorrhageDelayed presentationMulticenter studyEffect of intravenous thrombolysis before endovascular therapy on outcomes in patients with large core infarct
Anadani M, Almallouhi E, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Samaniego E, Arthur A, Yoshimura S, Cuellar H, Howard B, Alawieh A, Fragata I, Polifka A, Mascitelli J, Osbun J, Matouk C, Park M, Levitt M, Dumont T, Williamson R, Spiotta A. Effect of intravenous thrombolysis before endovascular therapy on outcomes in patients with large core infarct. Journal Of NeuroInterventional Surgery 2023, 15: jnis-2022-019537. PMID: 36990690, DOI: 10.1136/jnis-2022-019537.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScorePropensity score matching analysisEfficacy of bridging therapyScore matching analysisTreated with MTIntravenous thrombolysisIntracerebral hemorrhageCore infarctBridging therapyMatched cohortMechanical thrombectomyIncreased risk of hemorrhageRisk of hemorrhageMatching analysisEffect of intravenous thrombolysisCT scoreBaseline characteristicsEndovascular therapyFavorable outcomeRetrospective analysisCompare outcomesIncreased riskPatientsSafety outcomesAneurysm Registry
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