2024
The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome
Koo B, Abdelfattah A, Eysa A, Lu L. The Melanocortin and Endorphin Neuropeptides in Patients with Restless Legs Syndrome. Annals Of Neurology 2024, 95: 688-699. PMID: 38308537, DOI: 10.1002/ana.26876.Peer-Reviewed Original ResearchRestless legs syndromeRestless legs syndrome patientsRestless legs syndrome severityAdrenocorticotropin hormoneCerebrospinal fluidB-endorphinPro-opiomelanocortinA-MSHPlasma adrenocorticotropin hormoneRLS participantsInternational RLS Study Group Severity ScaleRLS patientsAssessed plasmaPain symptomsLumbar punctureA-melanocyte-stimulating hormoneMatched controlsPatientsHormoneSeverity ScaleSensory discomfortPlasmaSeverityMelanocortin hormonesHyperalgesia
2020
Hypothyroidism in restless legs syndrome
Ahmed N, Kandil M, Elfil M, Jamal A, Koo BB. Hypothyroidism in restless legs syndrome. Journal Of Sleep Research 2020, 30: e13091. PMID: 32483857, DOI: 10.1111/jsr.13091.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLegs syndromeRLS severityHigh prevalenceInternational RLS Study Group Severity ScaleHypothyroid participantsHypothyroidism prevalenceRLS FoundationRLS pathophysiologyRLS sufferersRLS prevalenceHypothyroid subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryStudy objectiveSyndromePotential research participantsBiological mechanismsSeverityParticipantsPersonsHyperthyroidism
2018
Suicidal thought and behavior in individuals with restless legs syndrome
Para KS, Chow CA, Nalamada K, Kakade VM, Chilakamarri P, Louis ED, Koo BB. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Medicine 2018, 54: 1-7. PMID: 30529070, DOI: 10.1016/j.sleep.2018.09.019.Peer-Reviewed Original ResearchConceptsRestless legs syndromeInternational RLS Study Group Severity ScaleLifetime suicidal ideationLifetime depression historySuicidal ideationDepression historyLegs syndromeControl participantsBrief Lifetime Depression ScaleCambridge-Hopkins RLS questionnairePotential demographic confoundersRisk of suicideStepwise logistic regressionRLS sufferersRLS questionnaireRLS diagnosisRLS severityDepression ScaleSuicidal Behaviors QuestionnaireLifetime depressionSeverity ScaleDemographic confoundersSuicidal thoughtsLogistic regressionDepressionRestless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis
Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.Peer-Reviewed Original ResearchConceptsRestless legs syndromePrevalence of RLSConcurrent restless legs syndromePeriodic limb movementsMulti-Ethnic StudyLegs syndromeObesity statusOdds of RLSLimb movementsPrevalence of PLMSCommunity-based sampleRace/ethnicityRLS symptomsClinical criteriaAdjusted modelPLMSStudy participantsPrevalenceOlder individualsCross-sectional dataAtherosclerosisSexSyndromeWhite participantsSleep
2016
Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance
Ferri R, Koo BB, Picchietti DL, Fulda S. Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance. Sleep Medicine 2016, 31: 29-38. PMID: 28341521, DOI: 10.1016/j.sleep.2016.05.014.Peer-Reviewed Original ResearchConceptsRestless legs syndromePeriodic leg movementsLeg movementsLeg motor activityLegs syndromePathophysiological correlatesClinical correlatesObjective findingsClinical significanceClinical conditionsNeurophysiologic aspectsCurrent evidencePLMSMotor phenomenaMotor activityAge groupsTypical phenotypeSleepRecent findingsCurrent knowledgeFurther researchCorrelatesFindingsPhenotypeScoringRestless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergicRestless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency
2015
Quality measures for the care of adult patients with restless legs syndrome.
Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD. Quality measures for the care of adult patients with restless legs syndrome. Journal Of Clinical Sleep Medicine 2015, 11: 293-310. PMID: 25700882, PMCID: PMC4346652, DOI: 10.5664/jcsm.4550.Peer-Reviewed Original ResearchConceptsRestless legs syndromeAccuracy of diagnosisAdult patientsLegs syndromeTreatment complicationsSymptom severityCare of patientsCommon sleep disorderEvidence-based treatmentsPotential side effectsQuality measure developmentRLS managementIron storesSleep disordersControl disordersDiagnostic criteriaSide effectsBetter outcomesRoutine assessmentAmerican AcademySleep medicinePatientsOutcomesSeverityComplications
2008
α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?
Koo BB, Feng P, Dostal J, Strohl KP. α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome? Movement Disorders 2008, 23: 1234-1242. PMID: 18464280, PMCID: PMC7350876, DOI: 10.1002/mds.22035.Peer-Reviewed Original ResearchConceptsSlow-wave sleep IIRestless legs syndromeAdrenocorticotropic hormoneAlpha-MSHParadoxical sleepLegs syndromeQuiet wakePathogenesis of RLSAlpha-melanocyte stimulating hormoneActive wakeMeasurement of sleepIntracerebral cannulaeIntracerebroventricular administrationSleep fragmentationNormal salineSleep latencyStimulating hormoneSleep architectureFragmented sleepOwn controlMotor activityRatsSleepLimb movementsHormone