2018
1015 Frequent Periodic Limb Movements During Sleep and Risk of Incident Stroke
May A, Koo B, Yaffe K, Leng Y, Cawthon P, Redline S, Stone K, Mehra R. 1015 Frequent Periodic Limb Movements During Sleep and Risk of Incident Stroke. Sleep 2018, 41: a376-a377. DOI: 10.1093/sleep/zsy061.1014.Peer-Reviewed Original ResearchBody mass indexIncident stroke riskPeriodic limb movementsStroke riskIncident strokeMulti-center prospective studyLimb movementsApnea-hypopnea indexAF findingsHypopnea indexMedian ageMedication useTotal cholesterolMass indexSleep apneaArousal indexProspective studyAutonomic dysregulationPhysical activityPLMSSignificant interactionStrokeLogistic regressionAlcohol useAge
2016
Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency