Distinct Glucocorticoid Receptor Transcriptional Regulatory Surfaces Mediate the Cytotoxic and Cytostatic Effects of Glucocorticoids
Rogatsky I, Hittelman A, Pearce D, Garabedian M. Distinct Glucocorticoid Receptor Transcriptional Regulatory Surfaces Mediate the Cytotoxic and Cytostatic Effects of Glucocorticoids. Molecular And Cellular Biology 1999, 19: 5036-5049. PMID: 10373553, PMCID: PMC84339, DOI: 10.1128/mcb.19.7.5036.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCell CycleCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27CyclinsCytotoxicity, ImmunologicDimerizationGlucocorticoidsHumansMicrotubule-Associated ProteinsMifepristoneMutagenesisProto-Oncogene Proteins c-bcl-2Receptors, GlucocorticoidTranscriptional ActivationTumor Cells, CulturedTumor Suppressor ProteinsConceptsTranscriptional repression functionRepression of Bcl2Saos2 cellsTranscriptional regulatory mechanismsAF-1Transcriptional activation functionTransactivation-deficient mutantAF-2Cyclin-dependent kinase inhibitorRepression functionTranscriptional activatorGlucocorticoid receptorRegulatory surfaceTarget genesCell contextReceptor dimerizationRegulatory mechanismsCytostatic actionHuman osteosarcoma cellsVariety of cellsGR mutantsCytostatic effectMolecular mechanismsCytotoxic effectsU20S cells