Reducing self-harm in adolescents: the RISA-IPD individual patient data meta-analysis and systematic review
Cottrell D, Wright-Hughes A, Farrin A, Walwyn R, Mughal F, Truscott A, Diggins E, Irving D, Fonagy P, Ougrin D, Stahl D, Wright J. Reducing self-harm in adolescents: the RISA-IPD individual patient data meta-analysis and systematic review. Health Technology Assessment 2024, 1-42. PMID: 39024118, DOI: 10.3310/gtnt6331.Peer-Reviewed Original ResearchRepetition of self-harmNational Institute for Health and Care ResearchIndividual patient data meta-analysisPatient data meta-analysisData meta-analysisSelf-harmSample of participantsSystematic reviewMeta-analysisMeta-analysesPrimary outcomeRisk of bias assessmentLow risk of biasHistory of self-harmPreferred Reporting ItemsReduce self-harmRandomised controlled trialsRisk of biasConventional meta-analysesIndividual Patient DataCare researchPublic health concernEligible participantsClinical servicesIssues of research designClinical effectiveness and cost-effectiveness of a brief accessible cognitive behavioural therapy programme for stress in school-aged adolescents (BESST): a cluster randomised controlled trial in the UK
Brown J, James K, Lisk S, Shearer J, Byford S, Stallard P, Deighton J, Saunders D, Yarrum J, Fonagy P, Weaver T, Sclare I, Day C, Evans C, Carter B. Clinical effectiveness and cost-effectiveness of a brief accessible cognitive behavioural therapy programme for stress in school-aged adolescents (BESST): a cluster randomised controlled trial in the UK. The Lancet Psychiatry 2024, 11: 504-515. PMID: 38759665, DOI: 10.1016/s2215-0366(24)00101-9.Peer-Reviewed Original ResearchTreatment-as-usualCognitive behavioral therapyTreatment-as-usual groupCluster randomised controlled trialCognitive behavioral therapy workshopRandomised controlled trialsCognitive behavioural therapy programmeSymptoms of depressionBehavioural therapy programmePrimary intention-to-treat analysisSchools TrialIndex of Multiple DeprivationBehavioral therapyDepressive symptomsHealth Technology Assessment programmeSchool-aged adolescentsControlled trialsSelf-referral systemIntention-to-treat populationDiscover interventionsFull school yearMental healthDepressionTherapy programmeIntention-to-treat analysisBrief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics
James K, Lisk S, Payne-Cook C, Farishta Z, Farrelly M, Sheikh A, Slusarczyk M, Byford S, Day C, Deighton J, Evans C, Fonagy P, Saunders D, Sclare I, Shearer J, Stallard P, Weaver T, Yarrum J, Carter B, Brown J. Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16–18-year-olds: recruitment and baseline characteristics. Trials 2024, 25: 302. PMID: 38702825, PMCID: PMC11069277, DOI: 10.1186/s13063-024-08116-7.Peer-Reviewed Original ResearchConceptsSchool-based cluster randomised controlled trialWarwick-Edinburgh Mental Wellbeing ScaleCluster randomised controlled trialRandomised controlled trialsSchools TrialEducational workshopsMental Wellbeing ScaleControlled trialsOutcome data collectionSymptoms of depressionEthnic minority groupsSecondary schoolsReduce stigmaBaseline characteristicsPost-randomisationWellbeing ScaleSelf-referralSelf-referredLower wellbeingStudentsDistressed studentsEthnically diverse sampleSchoolWorkshop programmeGeneral wellbeingImplementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial
Fonagy P, Chammay R, Ngunu C, Kumar M, Verdeli L, Allison E, Anani G, Fearon P, Fouad F, Hoare Z, Koyio L, Moore H, Nyandigisi A, Pilling S, Sender H, Skordis J, Evans R, Jaoude G, Madeghe B, Maradian S, O’Donnell C, Simes E, Truscott A, Wambua G, Yator O. Implementing and evaluating group interpersonal therapy for postnatal depression in Lebanon and Kenya—individually randomised superiority trial. Trials 2024, 25: 217. PMID: 38532432, PMCID: PMC10964704, DOI: 10.1186/s13063-024-08039-3.Peer-Reviewed Original ResearchConceptsPostnatal depressionInterpersonal psychotherapyChild developmental outcomesMulti-site randomised controlled trialWomen's mental health needsStandard careEfficacy of interpersonal psychotherapyMaternal postnatal depressionMental health needsMental health concernsMiddle-income countriesRandomised controlled trialsDevelopmental outcomesHigh-income countriesAntenatal servicesChildbearing womenMother-child bondingRandomised superiority trialChildren's developmental progressHealth needsOffspring of womenMaternal depressionCommunity settingsLMIC contextsInterpersonal therapyEnhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial
Williams A, Cleare S, Borschmann R, Tench C, Gross J, Hollis C, Chapman-Nisar A, Naeche N, Townsend E, Slovak P, Youth O, Creswell C, Fonagy P, Arseneault L, Lloyd E, De Alcantara Mendes J, Holter C, Jirotka M, Lazar Z, Patalay P, Kelly Y, Kandola A, Sonuga-Barke E, Livingstone S, Kostryka-Allchorne K, Bourgaize J, Stoilova M, O’Connor R, Auer D, Lee S, Jawahar N, Etherson M, Greenhalgh C, Sayal K, Warren J, Wanniarachchi V, Glover K, Stallard P, Hall C, Lucassen M, Merry S, Stasiak K, Babbage C, Khan K, Parker A, Lockwood J, Gregory J, Nielsen E, Vallejos E, Woodcock R, Doherty S, Willingham L. Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial. BMJ Open 2024, 14: e079801. PMID: 38195171, PMCID: PMC10806609, DOI: 10.1136/bmjopen-2023-079801.Peer-Reviewed Original ResearchConceptsSelf-harm ideationSelf-harmEmotion dysregulationEmotion regulationRandomised controlled trialsWaitlist controlEnhance emotion regulationExperiences of self-harmSocially assistive robotsSelf-Harm QuestionnaireSelf-harm thoughtsControlled trialsPeer-reviewed open access journalsLGBTQ+ youthPeople’s own viewsAssistive robotsControl participantsIntervention participantsAcceptable interventionSemistructured interviewsLinear mixed modelsPreliminary evidenceEthical approvalKing's College LondonSecondary outcomesBrief Educational Workshops in Secondary Schools Trial (BESST): a cluster randomised controlled trial. Secondary analysis in those with elevated symptoms of depression
Lisk S, James K, Shearer J, Byford S, Stallard P, Deighton J, Saunders D, Yarrum J, Fonagy P, Weaver T, Sclare I, Day C, Evans C, Carter B, Brown J. Brief Educational Workshops in Secondary Schools Trial (BESST): a cluster randomised controlled trial. Secondary analysis in those with elevated symptoms of depression. BMJ Mental Health 2024, 27: e301192. PMID: 39209761, PMCID: PMC11367360, DOI: 10.1136/bmjment-2024-301192.Peer-Reviewed Original ResearchConceptsTreatment-as-usualCluster randomised controlled trialNational Health ServiceElevated symptoms of depressionQuality-adjusted life yearsElevated depressive symptomsSymptoms of depressionRandomised controlled trialsDepressive symptomsSchools TrialElevated symptomsEducational workshopsIntention-to-treatSecondary analysisPersonal Social Services perspectiveControlled trialsMultilevel linear regressionSocial Services perspectiveSchool-based interventionsCost-effectiveIntention-to-treat analysisOutcomes of participantsHealth servicesIncremental cost-effectiveness ratioClinically meaningful effect