2022
A genetically informed Registered Report on adverse childhood experiences and mental health
Baldwin J, Sallis H, Schoeler T, Taylor M, Kwong A, Tielbeek J, Barkhuizen W, Warrier V, Howe L, Danese A, McCrory E, Rijsdijk F, Larsson H, Lundström S, Karlsson R, Lichtenstein P, Munafò M, Pingault J. A genetically informed Registered Report on adverse childhood experiences and mental health. Nature Human Behaviour 2022, 7: 269-290. PMID: 36482079, PMCID: PMC7614239, DOI: 10.1038/s41562-022-01482-9.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Childhood ExperiencesChildHumansMental DisordersMental HealthParentsRisk FactorsUnited StatesConceptsMental health problemsAdverse childhood experiencesHealth problemsElevated riskMental healthGenetic confoundingChildhood experiencesPsychiatric vulnerabilityGenetic riskHigher polygenic scoresConfoundingChildrenPrevious associationsRiskGene-environment correlationSmall increaseAssociationHealthReportPolygenic scores
2020
Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity
Viding E, McCrory E. Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity. American Journal Of Psychiatry 2020, 177: 811-817. PMID: 32867523, DOI: 10.1176/appi.ajp.2020.20070998.Peer-Reviewed Original Research
2019
Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying
Schoeler T, Choi S, Dudbridge F, Baldwin J, Duncan L, Cecil C, Walton E, Viding E, McCrory E, Pingault J. Multi–Polygenic Score Approach to Identifying Individual Vulnerabilities Associated With the Risk of Exposure to Bullying. JAMA Psychiatry 2019, 76: 730-738. PMID: 30942833, PMCID: PMC6583782, DOI: 10.1001/jamapsychiatry.2019.0310.Peer-Reviewed Original ResearchConceptsMental health vulnerabilitiesMAIN OUTCOMEPopulation-based birth cohort studyHealth vulnerabilityIndividual vulnerabilityBody mass indexBirth cohort studyDiagnosis of depressionYears of ageDate of deliveryAttention-deficit/hyperactivity disorderAvon Longitudinal StudyMental health problemsPolygenic score approachLast followCohort studyMass indexMultivariable analysisRisk of exposureAssessment of exposureRisk factorsPrevention strategiesHealth problemsSignificant associationALSPAC dataNeurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning
McCrory E, Ogle J, Gerin M, Viding E. Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning. Child Maltreatment 2019, 24: 435-451. PMID: 30897955, DOI: 10.1177/1077559519830524.Peer-Reviewed Original ResearchConceptsSocial functioningEarly maltreatment experiencesMental health vulnerabilitiesMental health problemsNeurocognitive adaptationsEmotion regulationThreat processingStudy of childrenReward processingComputational psychiatryMental health disordersMaltreatment experiencesLatent vulnerabilityChildhood maltreatmentSocial supportFunctioningHealth disordersNeural functionMaltreatmentHealth vulnerabilityProcessingHealth problemsVulnerabilityKey findingsAdolescents
2017
Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation
Hoffmann F, Puetz V, Viding E, Sethi A, Palmer A, McCrory E. Risk-taking, peer-influence and child maltreatment: A neurocognitive investigation. Social Cognitive And Affective Neuroscience 2017, 13: nsx124-. PMID: 29069467, PMCID: PMC5793726, DOI: 10.1093/scan/nsx124.Peer-Reviewed Original ResearchConceptsRight anterior insulaMT groupBalloon Analogue Risk TaskMore anxiety symptomsPsychiatric disordersAnterior insulaFuture psychopathologyAnxiety symptomsChildrenDifferential effectsNeural correlatesNeurocognitive investigationsRisk-taking behaviorPeer influenceChild maltreatmentRiskGroupNeural levelMaltreatmentRisk TaskSymptomsInsula
2016
Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability
Cecil C, Smith R, Walton E, Mill J, McCrory E, Viding E. Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. Journal Of Psychiatric Research 2016, 83: 184-194. PMID: 27643477, DOI: 10.1016/j.jpsychires.2016.09.010.Peer-Reviewed Original ResearchConceptsEpigenetic signaturesDNA methylationBiological processesMethylomic variationUnique epigenetic signatureGene ontology analysisSpecific biological processesHigh-confidence associationsUnique methylation patternOrganismal growthOntology analysisEpigenetic processesMethylation patternsMolecular linkEpithelial cell samplesNeural developmentNovel insightsNovel potential biomarkersMethylationCell samplesStringent setPotential pathwaysGenomePotential biomarkersBuccal epithelial cell samples
2015
The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder
McCrory E, Viding E. The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder. Development And Psychopathology 2015, 27: 493-505. PMID: 25997767, DOI: 10.1017/s0954579415000115.Peer-Reviewed Original ResearchConceptsPsychiatric disordersMental health problemsLatent vulnerabilityPsychiatric riskHealth problemsClinical interventionsDisordersNeurocognitive domainsPrevention approachesChildhood maltreatmentIntervention opportunitiesRisk trajectoriesPsychiatry approachMemory processingInterventionThreat processingChildrenRiskVulnerable childrenMaltreatmentLong termLife spanRisk environmentMaltreating environment
2010
Etiology of Different Developmental Trajectories of Callous-Unemotional Traits
Fontaine N, Rijsdijk F, McCrory E, Viding E. Etiology of Different Developmental Trajectories of Callous-Unemotional Traits. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 656-664. PMID: 20610135, DOI: 10.1016/j.jaac.2010.03.014.Peer-Reviewed Original Research