2022
A genetically informed Registered Report on adverse childhood experiences and mental health
Baldwin J, Sallis H, Schoeler T, Taylor M, Kwong A, Tielbeek J, Barkhuizen W, Warrier V, Howe L, Danese A, McCrory E, Rijsdijk F, Larsson H, Lundström S, Karlsson R, Lichtenstein P, Munafò M, Pingault J. A genetically informed Registered Report on adverse childhood experiences and mental health. Nature Human Behaviour 2022, 7: 269-290. PMID: 36482079, PMCID: PMC7614239, DOI: 10.1038/s41562-022-01482-9.Peer-Reviewed Original ResearchConceptsMental health problemsAdverse childhood experiencesHealth problemsElevated riskMental healthGenetic confoundingChildhood experiencesPsychiatric vulnerabilityGenetic riskHigher polygenic scoresConfoundingChildrenPrevious associationsRiskGene-environment correlationSmall increaseAssociationHealthReportPolygenic scoresSocial thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability
McCrory E, Foulkes L, Viding E. Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability. The Lancet Psychiatry 2022, 9: 828-837. PMID: 35926524, DOI: 10.1016/s2215-0366(22)00202-4.Peer-Reviewed Original ResearchConceptsTransactional modelChildhood maltreatmentNeurocognitive alterationsPsychiatric disordersQuantity of relationshipsIndividual's social networkSocial functioningSocial architecturePsychiatric vulnerabilityMaltreatmentSocial environmentExtant evidencePsychiatric riskNeurocognitive sequelaeSocial processesStress generationSocial networksDisorders
2017
A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children
Gerin M, Puetz V, Blair R, White S, Sethi A, Hoffmann F, Palmer A, Viding E, McCrory E. A neurocomputational investigation of reinforcement-based decision making as a candidate latent vulnerability mechanism in maltreated children. Development And Psychopathology 2017, 29: 1689-1705. PMID: 29162176, DOI: 10.1017/s095457941700133x.Peer-Reviewed Original ResearchConceptsMaltreated groupReinforcement-based decisionEarly adverse environmentsFunctional magnetic resonanceSuperior temporal gyrusMedial temporal structuresPassive avoidance taskMiddle cingulate gyrusNegative cuesReinforcement expectanciesMaltreated childrenPsychosocial functioningTemporal gyrusPrediction errorVulnerability mechanismsAvoidance taskNonmaltreated peersOrbitofrontal cortexLatent vulnerabilityChildhood abuseWidespread networkValue processingPsychiatric vulnerabilityValue representationCingulate gyrus
2012
Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children
De Brito S, Viding E, Sebastian C, Kelly P, Mechelli A, Maris H, McCrory E. Reduced orbitofrontal and temporal grey matter in a community sample of maltreated children. Journal Of Child Psychology And Psychiatry 2012, 54: 105-112. PMID: 22880630, DOI: 10.1111/j.1469-7610.2012.02597.x.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexPsychiatric disordersMiddle temporal gyrusOrbitofrontal cortexTemporal lobeGray matterTemporal gyrusConcurrent psychiatric disordersTemporal gray matterGray matter volumeVoxel-based morphometryCommunity sampleLeft middle temporal gyrusAtypical neural structurePrevious neuroimaging studiesNeurobiological risk factorsRisk factorsLevel of anxietyMatter volumePosttraumatic stress symptomsPsychiatric vulnerabilityConcurrent anxietyPrefrontal cortexCortexNeuroimaging studies
2011
The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors
McCrory E, De Brito S, Viding E. The Impact of Childhood Maltreatment: A Review of Neurobiological and Genetic Factors. Frontiers In Psychiatry 2011, 2: 48. PMID: 21847382, PMCID: PMC3148713, DOI: 10.3389/fpsyt.2011.00048.Peer-Reviewed Original ResearchChildhood maltreatmentFunctional brain differencesFunctional MRI studyAdrenal axis stress responseCare-giving experienceMagnetic resonance imaging studyResonance imaging studyAtypical developmentEmotional developmentAtypical activationNeurobiological correlatesAmygdala hyperactivityBrain differencesFrontal regionsPsychiatric vulnerabilityEnvironmental adversityBehavioral studiesChildhood historyInformation biasesMaltreatmentPreliminary evidenceSuch experiencesStructural MRINeuroendocrine findingsSignificant risk factors
2010
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory E, De Brito SA, Viding E. Research Review: The neurobiology and genetics of maltreatment and adversity. Journal Of Child Psychology And Psychiatry 2010, 51: 1079-1095. PMID: 20546078, DOI: 10.1111/j.1469-7610.2010.02271.x.Peer-Reviewed Original ResearchConceptsChildhood maltreatmentEarly adversityFunctional brain differencesIndividual's genetic makeAdrenal axis stress responseAtypical developmentEmotional developmentNeurobiological developmentAtypical activationNeurobiological mechanismsBrain differencesPrefrontal cortexPsychiatric vulnerabilityEnvironmental experiencesAdversityEnvironmental adversityBrain regionsEarly stressMaltreatmentNeuroendocrine findingsChildrenAdultsCorpus callosumGenetic makeHuman studies