Major Gift Will Support an Innovative Brain Research Collaboration
The Swiss-based NOMIS Foundation is making a large five-year award for research into what makes the human brain unique. The research will be a collaboration between the laboratories of James P. Noonan, PhD, associate professor of genetics and of neuroscience at Yale School of Medicine, and Franck Polleux, PhD, professor of neuroscience at Columbia University and a member of that school’s Zuckerman Institute. Their combined mission is to understand the brain and mind.
Psychiatric disorders share an underlying genetic basis
Thomas Fernandez, MD, Assistant Professor in the Child Study Center and of Psychiatry, and Christopher Pittenger, MD, PhD, Associate Professor of Psychiatry, contributed to a paper published in Science that explores the genetic connections between disorders of the brain at a scale that far eclipses previous work on the subject.
Fernandez appointed to Health and Human Services panel
Thomas V. Fernandez, MD, Assistant Professor in the Child Study Center and of Psychiatry, has been appointed to serve as a member of the U.S. Department of Health and Human Services Behavioral Genetics and Epidemiology Study Section, Center for Scientific Review.
How autism may stem from problems with prediction
A ‘predictive coding’ theory of autism suggests that many of the condition’s hallmark traits occur when sensory input overrides expectation in the brain. Yale researchers, Katarzyna Chawarska, James McPartland and Philip Corlett, are featured.Source: Spectrum
Tourette disorder study judged among top 5 articles in 2017 by journal Neuron
Thomas V. Fernandez, MD, Assistant Professor in the Child Study Center and of Psychiatry, was co-lead author of a genetic coding study of Tourette disorder patients judged among the top five articles published in 2017 by the journal Neuron.
Lab-created mini-brains reveal how growing organ maintains neuronal balance
Scientists can now explore in a laboratory dish how the human brain develops by creating organoids — distinct, three-dimensional regions of the brain. In research published in Cell Stem Cell, Yale scientists coaxed early stage stem cells to create and fuse two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons.
Genetic basis of some cases of Tourette’s disorder discovered
Researchers have discovered four genes that are associated with a higher risk of developing Tourette’s disorder, although variants in as many as 400 genes contribute to the origins of the complex neurological condition, which is marked by motor and vocal tics.
Genetic Study Reveals Pathways That May be Disrupted in People with OCD
A genetic study of children with obsessive-compulsive disorder (OCD) and their parents, reported March 29, 2016 in Translational Psychiatry, has yielded important hints about genes and biological pathways that may be involved in the disorder.Source: Brain and Behavior Research Foundation
Genomic analysis pinpoints a potential target for treatment of Down syndrome
A study of changes in the patterns of gene activity in the brains of people with Down syndrome reveals that the formation of the brain’s white matter is affected throughout life, a finding that suggests treatment might be possible for the condition that affects 400,000 Americans.
Yale Geneticist With Rare Disease to Build Pediatric Cell Atlas of Skeletal Muscle
A $3 million grant from the Chan Zuckerberg Initiative, awarded to a team of researchers led by Monkol Lek, PhD, assistant professor of genetics at Yale, will support Lek and his team in creating a Pediatric Cell Atlas of Skeletal Muscle — a roadmap of healthy skeletal cells and how they change at four key age group milestones between the ages of zero and 18 years.