2024
The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states
Vohs J, Srihari V, Vinson A, Lapidos A, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Breier A. The Academic Community Early Psychosis Intervention Network: Toward building a novel learning health system across six US states. Learning Health Systems 2024 DOI: 10.1002/lrh2.10471.Peer-Reviewed Original ResearchEarly Psychosis Intervention NetworkIntervention NetworkFirst-episode psychosisRegional clinical networksLearning health systemQuality improvement projectQuality improvement effortsCulture of continuous learningData elementsPrimary diagnosis of schizophreniaConsecutive 6-month intervalsFirst-episode psychosis clinicUsual careSuperior patient outcomesSpecialty servicesHealth systemClinical teamImplementation meetingsQuality assurance effortsImprovement projectClinical networksHealthcare systemPractice-based researchImprovement effortsQuality improvementThe Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program
Ferrara M, Basaldella M, Vacca F, Woods S, Walsh B, Cannon T, Srihari V, Grassi L. The Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program. Early Intervention In Psychiatry 2024 PMID: 38769052, DOI: 10.1111/eip.13548.Peer-Reviewed Original ResearchClinical high riskFirst-episode psychosisDSM-5-Attenuated Psychosis SyndromeItalian adaptationPsychosis syndromeDSM-5FEP programsEarly stages of psychosisItalian versionFirst-episode psychosis servicesFull-blown psychosisStages of psychosisEpisode of psychosisClinical structured interviewEpisode psychosisEstablished psychosisTrained psychologistsPsychiatric historyPsychosisPsychosis servicesHigh riskStructured interviewsClinical settingEarly detection of individualsAssess validityAntipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Szmulewicz A, Martínez-Alés G, Logan R, Ferrara M, Kelly C, Fredrikson D, Gago J, Conderino S, Díaz-Caneja C, Galvañ J, Thorpe L, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Öngür D, Hernán M, Collaboration O. Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration. American Journal Of Epidemiology 2024, 193: 1081-1087. PMID: 38576166, DOI: 10.1093/aje/kwae029.Peer-Reviewed Original ResearchFirst-episode psychosisFirst-generation agentsAntipsychotic therapyAntipsychotic drugsPsychosis onsetPsychotic disordersEpisode psychosisAripiprazolePaliperidoneRisk of hospitalizationPsychosisTarget trialsRisperidoneOlanzapineFirst-line therapyTreatment discontinuationEUFESTObservational cohortAntipsychoticsQuetiapineRandomized trialsPrimary outcomeAbsolute riskRisk differenceClinical questionsRole of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis
Venkataraman S, Hazan H, Li F, Ferrara M, Harper A, Ma J, Shah J, Musket C, Levine N, Keshavan M, Srihari V. Role of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis. Psychiatric Services 2024, 75: 427-433. PMID: 38204369, DOI: 10.1176/appi.ps.20230239.Peer-Reviewed Original ResearchDuration of untreated psychosisFirst-episode psychosis servicesFirst-episode psychosisEarly psychosis detectionLow personal incomeSocioeconomic statusUntreated psychosisOutcome of first-episode psychosisLength of duration of untreated psychosisEffectiveness of early detectionSpecialty care clinicsProlonged duration of untreated psychosisReduce duration of untreated psychosisEffects of ageLow socioeconomic statusPersonal incomeIndicators of disparitiesEarly detection effortsAssociated with younger ageYears of educationSES indicatorsCare clinicsEarly detectionBlack raceHierarchical regression
2023
579. Benchmarking Observational Analyses Against Randomized Trial Results: An Application to First Episode Psychosis
Szmulewicz A, Martinez-Ales G, Ferrara M, Fredrikson D, Gago J, Srihari V, Yatham L, Conderino S, Shinn A, Ongur D, Hernán M. 579. Benchmarking Observational Analyses Against Randomized Trial Results: An Application to First Episode Psychosis. Biological Psychiatry 2023, 93: s328-s329. DOI: 10.1016/j.biopsych.2023.02.819.Peer-Reviewed Original Research
2021
Establishing the Early Psychosis Intervention Clinic, New Orleans (EPIC-NOLA): Sustainability Challenges Threaten Clinical Success.
Weiss A, Chaudhry S, Cahill JD, Srihari VH. Establishing the Early Psychosis Intervention Clinic, New Orleans (EPIC-NOLA): Sustainability Challenges Threaten Clinical Success. Journal Of Health Care For The Poor And Underserved 2021, 32: 8-17. PMID: 33678676, DOI: 10.1353/hpu.2021.0003.Peer-Reviewed Original Research
2020
Analysis of Early Intervention Services on Adult Judicial Outcomes
Pollard JM, Ferrara M, Lin IH, Kucukgoncu S, Wasser T, Li F, Srihari VH. Analysis of Early Intervention Services on Adult Judicial Outcomes. JAMA Psychiatry 2020, 77: 871-872. PMID: 32320010, PMCID: PMC7177643, DOI: 10.1001/jamapsychiatry.2020.0448.Peer-Reviewed Original ResearchCognitive Effort and Amotivation in First-Episode Psychosis
Fortgang RG, Srihari V, Cannon TD. Cognitive Effort and Amotivation in First-Episode Psychosis. Journal Of Psychopathology And Clinical Science 2020, 129: 422-431. PMID: 32162929, DOI: 10.1037/abn0000509.Peer-Reviewed Original ResearchConceptsCognitive effortFirst-episode psychosisCognitive test performanceObserved cognitive deficitsAdditional monetary incentivesCognitive remediationCognitive tasksCognitive performanceDifficult trialsNovel taskCognitive deficitsAmotivationImpaired cognitionTest performanceCore featuresDisengagementLower overall accuracyHealthy community membersMonetary incentivesCurrent studyEpisode psychosisFEP patientsPsychotic disordersReduced effortTask
2019
Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases
Ferrara M, Tedeschini E, Baccari F, Musella V, Vacca F, Mazzi F, Ferri M, Srihari V, Starace F, Group F. Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases. Early Intervention In Psychiatry 2019, 13: 1011-1017. PMID: 30672134, DOI: 10.1111/eip.12788.Peer-Reviewed Original ResearchConceptsEarly intervention servicesClinical improvementMedian ageIntervention servicesCommunity mental health centerCommunity outpatient servicesPsychiatric hospital unitMeaningful clinical improvementFirst-episode psychosisModel of careNon-affective psychosisNation Outcome ScalesMental health centersHigher median ageEarly detection effortsRefinement of treatmentMain referralsPharmacological consultationYounger patientsUntreated psychosisOutcome ScaleGeneral practitionersEpisode psychosisHealth centersOutpatient services
2018
Development and validation of the client engagement and service use scale: A pilot study
Kline ER, DeTore NR, Keefe K, Seidman LJ, Srihari VH, Keshavan MS, Guyer M. Development and validation of the client engagement and service use scale: A pilot study. Schizophrenia Research 2018, 201: 343-346. PMID: 29764759, DOI: 10.1016/j.schres.2018.05.006.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisEpisode psychosisService utilizationPilot studyService Engagement ScaleMultiple intervention componentsClients' service utilizationClient engagementMedication adherenceSpecialty careEarly treatmentInter-rater reliabilitySession attendanceHigh inter-rater reliabilityTreatment teamIntervention componentsSpecialized treatmentMenu of servicesPreliminary evidenceCliniciansPsychosisConsumer advocacy groupsUse ScaleTreatmentMinimal trainingGlucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis
Kucukgoncu S, Kosir U, Zhou E, Sullivan E, Srihari VH, Tek C. Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis. Early Intervention In Psychiatry 2018, 13: 1021-1031. PMID: 30277314, PMCID: PMC6445792, DOI: 10.1111/eip.12749.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisSevere mental illnessGlucose metabolism outcomesTreatment-naïveEpisode psychosisMood disordersMental illnessSystematic reviewGlucose tolerance test resultsInsulin resistance levelsImpaired glucose metabolismFirst-episode patientsTolerance test resultsHigh-risk groupMood disorder groupGlucose intoleranceEpisode patientsDiabetes developmentMetabolism dysregulationEligible studiesHealthy controlsHigh insulinFEP groupGlucose metabolismPatientsComparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression
Correll CU, Galling B, Pawar A, Krivko A, Bonetto C, Ruggeri M, Craig TJ, Nordentoft M, Srihari VH, Guloksuz S, Hui CLM, Chen EYH, Valencia M, Juarez F, Robinson DG, Schooler NR, Brunette MF, Mueser KT, Rosenheck RA, Marcy P, Addington J, Estroff SE, Robinson J, Penn D, Severe JB, Kane JM. Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression. JAMA Psychiatry 2018, 75: 555-565. PMID: 29800949, PMCID: PMC6137532, DOI: 10.1001/jamapsychiatry.2018.0623.Peer-Reviewed Original ResearchConceptsEarly phase psychosisEarly intervention servicesCause treatment discontinuationSchizophrenia spectrum disordersSymptom severityTreatment discontinuationPsychiatric hospitalizationSystematic reviewIntervention servicesMonths of treatmentEnd of treatmentFirst-episode psychosisTotal symptom severitySystematic literature searchMeta-regression analysisPositive symptom severityCoprimary outcomesPrespecified subgroupsLanguage restrictionsNegative symptom severityClinical trialsTreatment periodMAIN OUTCOMESpectrum disorderPRISMA guidelines
2017
First-Episode Psychosis and the Criminal Justice System: Using a Sequential Intercept Framework to Highlight Risks and Opportunities
Wasser T, Pollard J, Fisk D, Srihari V. First-Episode Psychosis and the Criminal Justice System: Using a Sequential Intercept Framework to Highlight Risks and Opportunities. Psychiatric Services 2017, 68: 994-996. PMID: 28859587, DOI: 10.1176/appi.ps.201700313.Peer-Reviewed Original ResearchConceptsCriminal justice systemJustice systemSubsequent criminal justice involvementSequential Intercept ModelCriminal justice involvementCriminal justiceLegal outcomesDiversionary programsCaseload burdenHighlight risksJustice involvementClinical sphereIntercept modelFirst-episode psychosisMental health servicesJusticeEpisode psychosisHealth servicesRisk of aggressionSpherePsychosisRiskOpportunitiesFrameworkPatients
2015
Antipsychotic‐induced weight gain in first‐episode psychosis patients: a meta‐analysis of differential effects of antipsychotic medications
Tek C, Kucukgoncu S, Guloksuz S, Woods SW, Srihari VH, Annamalai A. Antipsychotic‐induced weight gain in first‐episode psychosis patients: a meta‐analysis of differential effects of antipsychotic medications. Early Intervention In Psychiatry 2015, 10: 193-202. PMID: 25962699, PMCID: PMC5589463, DOI: 10.1111/eip.12251.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisAP medicationFEP patientsBody weight gainBMI increaseWeight gainAP useBody mass index (BMI) changeSignificant body weight gainWeight gain riskMore weight gainComprehensive literature searchMean weight gainMeta-regression analysisBaseline weightBMI changeModifiable factorsBMI differencesMedicationsBMI outcomesPlaceboHigher weight gainBMILiterature searchPatientsFirst-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial
Srihari VH, Tek C, Kucukgoncu S, Phutane VH, Breitborde NJ, Pollard J, Ozkan B, Saksa J, Walsh BC, Woods SW. First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatric Services 2015, 66: 705-712. PMID: 25639994, PMCID: PMC4490067, DOI: 10.1176/appi.ps.201400236.Peer-Reviewed Original ResearchConceptsUsual treatmentSTEP participantsCommunity mental health centerFirst-episode servicesFirst-episode psychosisMental health centersSerious mental illnessInpatient psychiatric unitAntipsychotic exposureAdditional patientsIllness onsetHospital utilizationHealth centersInpatient utilizationPsychiatric hospitalizationMAIN OUTCOMEPsychotic illnessPsychiatric unitPsychotic disordersHospitalizationEarly interventionMental illnessSpecialized treatmentPatientsTranslational research
2012
Self-determination and first-episode psychosis: Associations with symptomatology, social and vocational functioning, and quality of life
Breitborde NJ, Kleinlein P, Srihari VH. Self-determination and first-episode psychosis: Associations with symptomatology, social and vocational functioning, and quality of life. Schizophrenia Research 2012, 137: 132-136. PMID: 22445463, PMCID: PMC3351585, DOI: 10.1016/j.schres.2012.02.026.Peer-Reviewed Original ResearchConceptsSelf-determination theoryBasic psychological needsNeed satisfactionPsychological needsFirst-episode psychosisNeed of relatednessSample of individualsEarly intervention servicesVocational functioningLess satisfactionIntervention servicesSatisfactionCurrent studyPsychosisIndividualsModest associationBeingQuality of lifeFunctioningMotivationSymptomatologyAssociationNeedDomainRelatedness
2009
Review of the operational definition for first‐episode psychosis
Breitborde NJ, Srihari VH, Woods SW. Review of the operational definition for first‐episode psychosis. Early Intervention In Psychiatry 2009, 3: 259-265. PMID: 22642728, PMCID: PMC4451818, DOI: 10.1111/j.1751-7893.2009.00148.x.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisDuration of psychosisEarly psychosis patientsAntipsychotic medication useFirst treatment contactRecent-onset psychosisMedication usePsychosis patientsTreatment contactPsychotic illnessClinical servicesPsychosisIllnessResearch settingsDurationOperational definitionTreatmentReviewPatientsSelective reviewIndividuals