2023
The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis
Blanco-Vieira T, Radua J, Marcelino L, Bloch M, Mataix-Cols D, do Rosário M. The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis. Translational Psychiatry 2023, 13: 230. PMID: 37380645, PMCID: PMC10307810, DOI: 10.1038/s41398-023-02433-2.Peer-Reviewed Original ResearchConceptsFirst-degree relativesSystematic reviewPopulation-based studyGenetic epidemiologyRelatives of childrenOutcomes of interestFirst systematic reviewObsessive-compulsive disorderRecurrence rateFamilial recurrence rateMedical recordsOpenGrey databasesControl groupControl probandsFamilial disorderAdolescent probandsStudy designEpidemiologyTwin study designOCD diagnosisIndependent researchersDizygotic twinsTwin pairsDisordersOCD
2015
Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children
Alvarenga PG, do Rosario MC, Cesar RC, Manfro GG, Moriyama TS, Bloch MH, Shavitt RG, Hoexter MQ, Coughlin CG, Leckman JF, Miguel EC. Obsessive–compulsive symptoms are associated with psychiatric comorbidities, behavioral and clinical problems: a population-based study of Brazilian school children. European Child & Adolescent Psychiatry 2015, 25: 175-182. PMID: 26015374, DOI: 10.1007/s00787-015-0723-3.Peer-Reviewed Original ResearchConceptsFamily History ScreenObsessive-compulsive disorderObsessive-compulsive symptomsSchool-aged childrenChild Behavior ChecklistUnaffected controlsPediatric-onset obsessive-compulsive disorderPresence of OCSPopulation-based studyComorbid psychiatric disordersMajor depressive disorderWell-Being AssessmentOCD groupBrazilian school childrenGroup of childrenPsychiatric comorbidityDepressive disorderClinical impactFunctional impairmentPsychiatric disordersClinical problemOCS groupDiagnostic groupsSignificant socio-demographic differencesSocio-demographic differences